T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.

abstract：:Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine [poly(Q)] expansion within ataxin-7, a protein of previously unknown function. Here, we report that ataxin-7 is an integral component of the mammalian STAGA (SPT3-TAF9-ADA-GCN5 acetyltransf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palhan VB,Chen S,Peng GH,Tjernberg A,Gamper AM,Fan Y,Chait BT,La Spada AR,Roeder RG

更新日期：2005-06-14 00:00:00

abstract：:Although an inverse relationship is expected in ancient DNA samples between the number of surviving DNA fragments and their length, ancient DNA sequencing libraries are strikingly deficient in molecules shorter than 40 bp. We find that a loss of short molecules can occur during DNA extraction and present an improved s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabney J,Knapp M,Glocke I,Gansauge MT,Weihmann A,Nickel B,Valdiosera C,García N,Pääbo S,Arsuaga JL,Meyer M

更新日期：2013-09-24 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:Alternative splicing is critical for diversifying eukaryotic proteomes, but the rules governing and coordinating splicing events among multiple alternate splice sites within individual genes are not well understood. We developed a quantitative PCR-based strategy to quantify the expression of the 12 transcripts encoded...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glauser DA,Johnson BE,Aldrich RW,Goodman MB

更新日期：2011-12-20 00:00:00

abstract：:Horizontal cells of the carp retina possess dopamine receptors linked to adenylate cyclase. Isolated, intact horizontal cells respond to micromolar concentrations of dopamine, whereas nanomolar concentrations of haloperidol, (+)-butaclamol, and flupenthixol block the dopamine response. Preincubation in Ringer's soluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Buskirk R,Dowling JE

更新日期：1982-05-01 00:00:00

abstract：:A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking program GRAMM was used to delete the atom-size structural details and systematically dock th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vakser IA,Matar OG,Lam CF

更新日期：1999-07-20 00:00:00

abstract：:In vitro incubation of leukemic bone marrow with the lipophilic fluorescent dye merocyanine 540 and simultaneous exposure to light reduced the concentration of L1210 leukemia cells by about 5 orders of magnitude but spared enough normal pluripotent hematopoietic stem cells to allow hematopoietic reconstitution of leth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sieber F,Spivak JL,Sutcliffe AM

更新日期：1984-12-01 00:00:00

abstract：:Sets of Burkitt lymphoma lines and Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) derived from the same individuals were compared for sensitivity to cytotoxic T-lymphocyte (CTL) clones. Major histocompatibility complex class I antigen-restricted CTL clones were generated by stimulating the lymph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torsteinsdottir S,Masucci MG,Ehlin-Henriksson B,Brautbar C,Ben Bassat H,Klein G,Klein E

更新日期：1986-08-01 00:00:00

abstract：:After each round of protein biosynthesis, the posttermination complex (PoTC) consisting of a ribosome, mRNA, and tRNA must be disassembled into its components for a new round of translation. Here, we show that a Saccharomyces cerevisiae model PoTC was disassembled by ATP and eukaryotic elongation factor 3 (eEF3). GTP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurata S,Nielsen KH,Mitchell SF,Lorsch JR,Kaji A,Kaji H

更新日期：2010-06-15 00:00:00

abstract：:In colloidal systems, the interplay between the short range attraction and long-range repulsion can lead to a low density associated state consisting of clusters of individual particles. Recently, such an equilibrium cluster phase was also reported for concentrated solutions of lysozyme at low ionic strength and close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla A,Mylonas E,Di Cola E,Finet S,Timmins P,Narayanan T,Svergun DI

更新日期：2008-04-01 00:00:00

abstract：:Group 3 innate lymphoid cells (ILC3s) have emerged as important cellular players in tissue repair and innate immunity. Whether these cells meaningfully regulate adaptive immune responses upon activation has yet to be explored. Here we show that upon IL-1β stimulation, peripheral ILC3s become activated, secrete cytokin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Burg N,Chappaz S,Baerenwaldt A,Horvath E,Bose Dasgupta S,Ashok D,Pieters J,Tacchini-Cottier F,Rolink A,Acha-Orbea H,Finke D

更新日期：2014-09-02 00:00:00

abstract：:The sequence of a nucleotide region of f1 bacteriophage was determined on a bonded ultrathin acrylamide gel with a discontinuous buffer system by using the dideoxy-DNA sequencing method. This sequence and one other were analyzed for maximal base pairing with tRNAs. The results allow a prediction of the direction and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pieczenik G

更新日期：1980-06-01 00:00:00

abstract：:Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3-4(m), delNAS(m)) from the GNAS locus in humans causes autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib(delNASm)), a disorder of proximal tubular parathyroid hormone (PTH) resistance associated with loss of maternal G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández-Rebollo E,Maeda A,Reyes M,Turan S,Fröhlich LF,Plagge A,Kelsey G,Jüppner H,Bastepe M

更新日期：2012-04-24 00:00:00

abstract：:Total nuclear proteins extracted from cell lines representing various stages of differentiation of mouse B lymphocytes were studied by computer analysis of two-dimensional gels. Of the 1438 spots present on the gels, 55 varied significantly in intensity during differentiation. The variations occurred most often in ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabilloud T,Pennetier JL,Hibner U,Vincens P,Tarroux P,Rougeon F

更新日期：1991-03-01 00:00:00

abstract：:Indoor residual spraying (IRS) is used to control visceral leishmaniasis (VL) in India, but it is poorly quality assured. Quality assurance was performed in eight VL endemic districts in Bihar State, India, in 2014. Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and DDT ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman M,Foster GM,Deb R,Pratap Singh R,Ismail HM,Shivam P,Ghosh AK,Dunkley S,Kumar V,Coleman M,Hemingway J,Paine MJ,Das P

更新日期：2015-07-14 00:00:00

abstract：:Mammalian nervous system function involves billions of neurons which are interconnected in a multitude of neural circuits. Here we describe a genetic approach to chart neural circuits. By using an olfactory-specific promoter, we selectively expressed barley lectin in sensory neurons in the olfactory epithelium and vom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz LF,Montmayeur JP,Echelard Y,Buck LB

更新日期：1999-03-16 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:A muscarone-binding material has been found in Torpedo electroplax. The material behaves in several ways as one would expect of the binding component of the acetylcholine receptor, especially in its high affinity for muscarone (approximate K = 7 x 10(-6)M), acetylcholine (approximate K = 1.1 x 10(-6)M), curare, and ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Brien RD,Gilmour LP

更新日期：1969-06-01 00:00:00

abstract：:The crystal structures of Escherichia coli thymidylate kinase (TmpK) in complex with P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate and P1-(5'-adenosyl)P5-[5'-(3'-azido-3'-deoxythymidine)] pentaphosphate have been solved to 2.0-A and 2.2-A resolution, respectively. The overall structure of the bacterial TmpK is very ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavie A,Ostermann N,Brundiers R,Goody RS,Reinstein J,Konrad M,Schlichting I

更新日期：1998-11-24 00:00:00

abstract：:Hematopoietic stem/progenitor cells (HSPCs) possess the potentials of self-renewal, proliferation, and differentiation toward different lineages of blood cells. These cells not only play a primordial role in hematopoietic development but also have important clinical application. Characterization of the gene expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao M,Fu G,Wu JS,Zhang QH,Zhou J,Kan LX,Huang QH,He KL,Gu BW,Han ZG,Shen Y,Gu J,Yu YP,Xu SH,Wang YX,Chen SJ,Chen Z

更新日期：1998-07-07 00:00:00

abstract：:Two-component signal transduction systems are most often found in prokaryotic organisms where they are responsible for mediating the cellular responses to many environmental stimuli. These systems are composed of an autophosphorylating histidine kinase and a response regulator. We have found evidence for the existence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alex LA,Borkovich KA,Simon MI

更新日期：1996-04-16 00:00:00

abstract：:Glucocorticoid hormones increase the level of hepatic tryptophan oxygenase (EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) by increasing its rate of synthesis. Studies were performed to determine whether this induction is mediated by controlling the level of the mRNA for tryptophan oxygenase of by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schutz G,Killewich L,Chen G,Feigelson P

更新日期：1975-03-01 00:00:00

abstract：:HLA-I molecules play a central role in antigen presentation. They typically bind 9- to 12-mer peptides, and their canonical binding mode involves anchor residues at the second and last positions of their ligands. To investigate potential noncanonical binding modes, we collected in-depth and accurate HLA peptidomics da...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guillaume P,Picaud S,Baumgaertner P,Montandon N,Schmidt J,Speiser DE,Coukos G,Bassani-Sternberg M,Filippakopoulos P,Gfeller D

更新日期：2018-05-15 00:00:00

abstract：:The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα-interacting protein. By shielding cytoplasmic OGT from proteasoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berthier A,Vinod M,Porez G,Steenackers A,Alexandre J,Yamakawa N,Gheeraert C,Ploton M,Maréchal X,Dubois-Chevalier J,Hovasse A,Schaeffer-Reiss C,Cianférani S,Rolando C,Bray F,Duez H,Eeckhoute J,Lefebvre T,Staels B,Lef

更新日期：2018-11-20 00:00:00

abstract：:The previously described peptide material that reacts with antibodies to gastrin and is found in the central nervous system of various vertebrates is present in only the 100,000 X g pellet of postmortem human cerebral cortical grey matter. This immunoreactive material, extractable in boiling water, is biologically act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robberecht P,Deschodt-Lanckman M,Vanderhaeghen JJ

更新日期：1978-01-01 00:00:00

abstract：:The levels of the neural axis from which parasympathetic and orthosympathetic neurons and adrenomedullary cells are derived under normal developmental conditions were determined in avian embryos by a biological labeling technique. The technique is based on nuclear differences between two species of birds, the chick an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Douarin NM,Renaud D,Teillet MA,Le Douarin GH

更新日期：1975-02-01 00:00:00

abstract：:Rat hepatoma cells infected with mouse mammary tumor virus contain multiple forms of unintegrated viral DNA when grown in the presence of glucocorticoids. Using the DNA transfer procedure of Southern, we have prepared restriction endonuclease fragment maps of these forms of viral DNA. The maps indicate that: (i) the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shank PR,Cohen JC,Varmus HE,Yamamoto KR,Ringold GM

更新日期：1978-05-01 00:00:00

abstract：:There has been an increasing interest in cyanobacteria because these photosynthetic organisms convert solar energy into biomass and because of their potential for the production of biofuels. However, the exploitation of cyanobacteria for bioengineering requires knowledge of their transcriptional organization. Using di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitschke J,Georg J,Scholz I,Sharma CM,Dienst D,Bantscheff J,Voss B,Steglich C,Wilde A,Vogel J,Hess WR

更新日期：2011-02-01 00:00:00

abstract：:Mood disorders cause much suffering and are the single greatest cause of lost productivity worldwide. Although multiple medications, along with behavioral therapies, have proven effective for some individuals, millions of people lack an effective therapeutic option. A common serotonin (5-HT) transporter (5-HTT/SERT, S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baganz NL,Horton RE,Calderon AS,Owens WA,Munn JL,Watts LT,Koldzic-Zivanovic N,Jeske NA,Koek W,Toney GM,Daws LC

更新日期：2008-12-02 00:00:00

abstract：:The spatial distribution of plant defenses within a leaf may be critical in explaining patterns of herbivory. The generalist lepidopteran larvae, Helicoverpa armigera (the cotton bollworm), avoided the midvein and periphery of Arabidopsis thaliana rosette leaves and fed almost exclusively on the inner lamina. This fee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shroff R,Vergara F,Muck A,Svatos A,Gershenzon J

更新日期：2008-04-22 00:00:00