High-pressure transformations in xenon hydrates.

abstract：:Learning to read requires the acquisition of an efficient visual procedure for quickly recognizing fine print. Thus, reading practice could induce a perceptual learning effect in early vision. Using functional magnetic resonance imaging (fMRI) in literate and illiterate adults, we previously demonstrated an impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegado F,Comerlato E,Ventura F,Jobert A,Nakamura K,Buiatti M,Ventura P,Dehaene-Lambertz G,Kolinsky R,Morais J,Braga LW,Cohen L,Dehaene S

更新日期：2014-12-09 00:00:00

abstract：:In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the promoter elements of various human papillomaviruses in transient-expression assays. We have analyzed the effect of dexamethaso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Knebel Doeberitz M,Bauknecht T,Bartsch D,zur Hausen H

更新日期：1991-02-15 00:00:00

abstract：:A complementary DNA (cDNA) clone from a human placenta cDNA library encoding extracellular superoxide dismutase (EC-SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) has been isolated and the nucleotide sequence determined. The cDNA has a very high G+C content. EC-SOD is synthesized with a putative 18-amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hjalmarsson K,Marklund SL,Engström A,Edlund T

更新日期：1987-09-01 00:00:00

abstract：:We examined the origins and functional evolution of the Shaker and KCNQ families of voltage-gated K(+) channels to better understand how neuronal excitability evolved. In bilaterians, the Shaker family consists of four functionally distinct gene families (Shaker, Shab, Shal, and Shaw) that share a subunit structure co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Liu H,Chu Luo J,Rhodes SA,Trigg LM,van Rossum DB,Anishkin A,Diatta FH,Sassic JK,Simmons DK,Kamel B,Medina M,Martindale MQ,Jegla T

更新日期：2015-03-03 00:00:00

abstract：:The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL-derived mRNA transcripts that can substitute for IL3 signaling. We demonstrate that CRL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoda A,Yoda Y,Chiaretti S,Bar-Natan M,Mani K,Rodig SJ,West N,Xiao Y,Brown JR,Mitsiades C,Sattler M,Kutok JL,DeAngelo DJ,Wadleigh M,Piciocchi A,Dal Cin P,Bradner JE,Griffin JD,Anderson KC,Stone RM,Ritz J,Foà R,

更新日期：2010-01-05 00:00:00

abstract：:Acetyl-CoA carboxylase 1 (ACC1) catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids. We have identified 64 exons, including 7 alternatively spliced minor exons (1A, 1B, 1C, 3, 5A', 5A, and 5B) in human ACC1 gene ( approximately 330 kb). The gene is regulated by three pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao J,Chirala SS,Wakil SJ

更新日期：2003-06-24 00:00:00

abstract：:A model for protein synthesis is proposed in which the donor for the peptide elongation reaction is peptidyl-5S RNA. Space-filling models show that peptide bond formation between peptidyl-5S RNA and aminoacyl-tRNA is eminently feasible from a stereochemical point of view. The peptide is transferred to 5S RNA, while at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raacke ID

更新日期：1971-10-01 00:00:00

abstract：:The concentration of urea in renal medullary cells is high enough to affect enzymes seriously by reducing Vmax or raising Km, yet the cells survive and function. The usual explanation is that the methylamines found in the renal medulla, namely glycerophosphocholine and betaine, have actions opposite to those of urea a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burg MB,Peters EM,Bohren KM,Gabbay KH

更新日期：1999-05-25 00:00:00

abstract：:Columnar stromatolites were abundant and widespread in the Proterozoic but are exceedingly rare in modern seas. Consequently, the stromatolites at Hamelin Pool in Shark Bay, Western Australia, have been widely interpreted as unique modern analogs of ancient stromatolites constructed by complex communities of cyanobact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awramik SM,Riding R

更新日期：1988-03-01 00:00:00

abstract：:The proliferating cell nuclear antigen (PCNA) acts as a processivity factor for replicative DNA polymerases and is essential for DNA replication. In vitro studies have suggested a role for PCNA-in the repair synthesis step of nucleotide excision repair, and PCNA interacts with the cyclin-dependent kinase inhibitor p21...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres-Ramos CA,Yoder BL,Burgers PM,Prakash S,Prakash L

更新日期：1996-09-03 00:00:00

abstract：:We present the discovery of an unusually large isotope effect in the structural relaxation and the glass transition temperature Tg of water. Dielectric relaxation spectroscopy of low-density as well as of vapor-deposited amorphous water reveal Tg differences of 10 ± 2 K between H2O and D2O, sharply contrasting with ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gainaru C,Agapov AL,Fuentes-Landete V,Amann-Winkel K,Nelson H,Köster KW,Kolesnikov AI,Novikov VN,Richert R,Böhmer R,Loerting T,Sokolov AP

更新日期：2014-12-09 00:00:00

abstract：:To understand non-trivial biological functions, it is crucial to develop minimal synthetic models that capture their basic features. Here, we demonstrate a sequence-independent, reversible control of transcription and gene expression using a photosensitive nucleic acid binder (pNAB). By introducing a pNAB whose affini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Estévez-Torres A,Crozatier C,Diguet A,Hara T,Saito H,Yoshikawa K,Baigl D

更新日期：2009-07-28 00:00:00

abstract：:Endosymbiotic acquisition of bacteria by a protist, with subsequent evolution of the bacteria into mitochondria and plastids, had a transformative impact on eukaryotic biology. Reconstructing events that created a stable association between endosymbiont and host during the process of organellogenesis--including establ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowack EC,Grossman AR

更新日期：2012-04-03 00:00:00

abstract：:The development of antimicrobials is critical in this time of increasing antibiotic resistance of most clinically relevant bacteria. To date, all current antibiotics focus on inhibiting crucial enzymatic activities of their protein targets (i.e., trimethoprim for dihydrofolate reductase), thus disrupting in vitro esse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakhnovich EA,Hung DT,Pierson E,Lee K,Mekalanos JJ

更新日期：2007-02-13 00:00:00

abstract：:In normal vision, shifts of attention are usually followed by saccadic eye movements. Neurons in extrastriate area V4 are modulated by focal attention when eye movements are withheld, but they also respond in advance of visually guided saccadic eye movements. We have examined the visual selectivity of saccade-related ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Tolias AS,Schiller PH

更新日期：1998-07-21 00:00:00

abstract：:Increased clouds and precipitation normally decrease the diurnal temperature range (DTR) and thus have commonly been offered as explanation for the trend of reduced DTR observed for many land areas over the last several decades. Observations show, however, that the DTR was reduced most in dry regions and especially in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Vose RS,Dai Y

更新日期：2007-11-13 00:00:00

abstract：:Xanthophyll pigments have critical structural and functional roles in the photosynthetic light-harvesting complexes of algae and vascular plants. Genetic dissection of xanthophyll metabolism in the green alga Chlamydomonas reinhardtii revealed functions for specific xanthophylls in the nonradiative dissipation of exce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niyogi KK,Björkman O,Grossman AR

更新日期：1997-12-09 00:00:00

abstract：:The replacement of dopamine (DA) by DA neuron transplants in the treatment of advanced Parkinson disease (PD) is a rational approach. Because of limitations associated with fetal tissue transplants, a clone (1RB3AN27) of simian virus 40 large tumor antigen (LTa) gene-induced immortalized DA neurons were used in this s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarkson ED,Rosa FG,Edwards-Prasad J,Weiland DA,Witta SE,Freed CR,Prasad KN

更新日期：1998-02-03 00:00:00

abstract：:Species- and strain-specific spontaneously occurring tumors have been observed in rodents maintained under normal laboratory conditions. Elucidation of the molecular mechanisms associated with the development of these spontaneous tumors may provide a better understanding of tumor development associated with exposure t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds SH,Stowers SJ,Maronpot RR,Anderson MW,Aaronson SA

更新日期：1986-01-01 00:00:00

abstract：:Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their bes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nirenberg S,Pandarinath C

更新日期：2012-09-11 00:00:00

abstract：:An RNA-directed DNA polymerase was isolated from the peripheral blood leukocytes of a patient with acute myelomonocytic leukemia by successive purification of a particulate cytoplasmic fraction with endogenous, ribonuclease-sensitive DNA polymerase activity. Like RNA-directed DNA polymerase from mammalian type-C virus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallagher RE,Todaro GJ,Smith RG,Livingston DM,Gallo RC

更新日期：1974-04-01 00:00:00

abstract：:MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts. It is a member of the large ParA superfamily of ATPases that are characterized by a deviant Walker-type ATP-binding motif. MinD localizes to the cytoplasmic face of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szeto TH,Rowland SL,Rothfield LI,King GF

更新日期：2002-11-26 00:00:00

abstract：:Mechanism of enzymatic conversion of a fatty acid to the corresponding alkane by the loss of the carboxyl carbon was investigated with particulate preparations from Pisum sativum. A heavy particulate preparation (sp. gr., 1.30 g/cm3) isolated by two density-gradient centrifugation steps catalyzed conversion of octadec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheesbrough TM,Kolattukudy PE

更新日期：1984-11-01 00:00:00

abstract：:Domestic animals can be cloned using techniques such as embryo splitting and nuclear transfer to produce genetically identical individuals. Although embryo splitting is limited to the production of only a few identical individuals, nuclear transfer of donor nuclei into recipient oocytes, whose own nuclear DNA has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keefer CL

更新日期：2015-07-21 00:00:00

abstract：:We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautsch JW,Knowles AF,Jensen FC,Kaplan NO

更新日期：1980-04-01 00:00:00

abstract：:Noncompliance with social distancing during the early stage of the coronavirus disease 2019 (COVID-19) pandemic poses a great challenge to the public health system. These noncompliance behaviors partly reflect people's concerns for the inherent costs of social distancing while discounting its public health benefits. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Campbell S,Zhang W

更新日期：2020-07-28 00:00:00

abstract：:Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage by interaction with a specific receptor. Early signal transduction events following G-CSF receptor activation were studied. We detected tyrosine phosphorylation of both the G-CSF receptor a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicholson SE,Oates AC,Harpur AG,Ziemiecki A,Wilks AF,Layton JE

更新日期：1994-04-12 00:00:00

abstract：:The β-1,3-glucan chrysolaminarin is the main storage polysaccharide of diatoms. In contrast to plants and green algae, diatoms and most other algal groups do not accumulate storage polysaccharides in their plastids. The diatom Phaeodactylum tricornutum possesses only a single gene encoding a putative β-1,3-glucan synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,Haferkamp I,Lepetit B,Molchanova M,Hou S,Jeblick W,Río Bártulos C,Kroth PG

更新日期：2018-05-01 00:00:00

abstract：:Supercritical fluids are a unique class of nonaqueous media in which biocatalytic reactions can occur. The physical properties of supercritical fluids, which include gas-like diffusivities and liquid-like densities, can be predictably controlled with changing pressure. This paper describes how adjustment of pressure, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamat SV,Iwaskewycz B,Beckman EJ,Russell AJ

更新日期：1993-04-01 00:00:00

abstract：:Human Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, synaptic activity, and retinal homeostasis. Mutations in hBest1 cause the autosomal-dominant Best macular dystrophy (BMD). Because hBest1 mutations cause BMD, but a knockout does not, we wondered if hBest1 mutants...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bharill S,Fu Z,Palty R,Isacoff EY

更新日期：2014-04-29 00:00:00