n-Type silicon photoelectrochemistry in methanol: Design of a 10.1% efficient semiconductor/liquid junction solar cell.

abstract：:The possible role of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) in protein synthesis by Escherichia coli ribosomes and protein factors was examined. Although pppGpp could effectively substitute for GTP in reactions catalyzed by initiation factor 2 (ribosomal binding of fMet-tRNA and formation of N-formylmethion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamel E,Cashel M

更新日期：1973-11-01 00:00:00

abstract：:Rat superior cervical sympathetic ganglion was used to begin studying the regulation of molecular components of the synapse. Ganglionic postsynaptic densities (PSDs)exhibited a thin, disc-shaped profile electron microscopically, comparable to that described for brain. Moreover, the presumptive ganglionic PSD protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu K,Black IB

更新日期：1987-12-01 00:00:00

abstract：:Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueta T,Ishihara K,Notomi S,Lee JJ,Maidana DE,Efstathiou NE,Murakami Y,Hasegawa E,Azuma K,Toyono T,Paschalis EI,Aihara M,Miller JW,Vavvas DG

更新日期：2019-11-19 00:00:00

abstract：:3-Deazaadenosine (DZA), 3-deaza-(+/-)-aristeromycin (DZAri), and 3-deazaneplanocin A (DZNep) are powerful modulators of cellular processes. When tested against H9 cells infected acutely with two different strains of human immunodeficiency virus 1 (HIV-1) and in the chronically infected monocytoid cell lines U1 and THP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayers DL,Mikovits JA,Joshi B,Hewlett IK,Estrada JS,Wolfe AD,Garcia GE,Doctor BP,Burke DS,Gordon RK

更新日期：1995-01-03 00:00:00

abstract：:The inability to perceive and coordinate both internal and external signals that function to regulate cellular growth and proliferation is a hallmark of oncogenic transformation. To examine the effects of the v-mos oncogene on distinct signal transduction pathways, the 6m2 cell line was used, in which expression of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton BJ,DeFranco D

更新日期：1989-01-01 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00

abstract：:The structure of the Rous sarcoma virus envelope glycoprotein complex was studied by sedimentation gradient centrifugation analyses of detergent-solubilized wild-type and mutant envelope (env) gene products. These studies show that the envelope glycoprotein forms an oligomer during biosynthesis, which is most likely a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einfeld D,Hunter E

更新日期：1988-11-01 00:00:00

abstract：:The F-box represents a protein motif originally identified as a conserved amino-terminal domain within the Neurospora crassa negative regulator sulfur controller-2. Recently, F-boxes have been found within a number of cell cycle regulatory proteins, where they mediate ubiquitin-driven proteolytic events required for m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Paietta JV

更新日期：1998-03-03 00:00:00

abstract：:Mechanical failure of soft tissues is characteristic of life-threatening diseases, including capillary stress failure, pulmonary emphysema, and vessel wall aneurysms. Failure occurs when mechanical forces are sufficiently high to rupture the enzymatically weakened extracellular matrix (ECM). Elastin, an important stru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritter MC,Jesudason R,Majumdar A,Stamenovic D,Buczek-Thomas JA,Stone PJ,Nugent MA,Suki B

更新日期：2009-01-27 00:00:00

abstract：:Short interfering RNA (siRNA) is widely used for studying gene function and holds great promise as a tool for validating drug targets and treating disease. A critical assumption in these applications is that the effect of siRNA on cells is specific, i.e., limited to the specific knockdown of the target gene. In this a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Semizarov D,Frost L,Sarthy A,Kroeger P,Halbert DN,Fesik SW

更新日期：2003-05-27 00:00:00

abstract：:During the process of fertilization in mammals, sperm bind in a relatively species-specific manner to the zona pellucida (ZP) of ovulated eggs. ZP3, a glycoprotein found in the mouse egg zona pellucida, serves as receptor for sperm during gamete adhesion. We report here that a Mr 56,000 protein found on mouse sperm ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleil JD,Wassarman PM

更新日期：1990-07-01 00:00:00

abstract：:The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation. The distributed odorant representation found in PCX contrasts sharply with the topographical representation seen in other primary sensory cortices, making it difficult to test this v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CF,Zou DJ,Altomare CG,Xu L,Greer CA,Firestein SJ

更新日期：2014-11-25 00:00:00

abstract：:HLA-A and -B antigens are phosphorylated in transformed lymphoblastoid cells and peripheral blood lymphocytes, both incubated with 32Pi. The phosphate group is attached to HLA-A and -B heavy chain (p44) as identified by immunoprecipitation with anti-beta2-microglobulin IgG, sodium dodecyl sulfate/polyacrylamide gel el...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pober JS,Guild BC,Strominger JL

更新日期：1978-12-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine; 0.5 microM and above) stimulated the synthesis of prostacyclin (as measured by radioimmunoassay of 6-ketoprostaglandin F1 alpha) by bovine aortic smooth muscle cells in culture. This effect was structurally specific; a similar response was not elicited by the other indoles (tryptophan, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coughlin SR,Moskowitz MA,Antoniades HN,Levine L

更新日期：1981-11-01 00:00:00

abstract：:This paper provides transcendental and algebraic framework for the classification of identities expressing pi and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky DV,Chudnovsky GV

更新日期：1998-03-17 00:00:00

abstract：:The early steps in the biosynthesis of Taxol involve the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene followed by cytochrome P450-mediated hydroxylation at C5, acetylation of this intermediate, and a second cytochrome P450-dependent hydroxylation at C10 to yield taxadien-5 alpha-acetoxy-10 beta-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoendorf A,Rithner CD,Williams RM,Croteau RB

更新日期：2001-02-13 00:00:00

abstract：:Peripheral inhibitory nerves are physiological regulators of the contractile behavior of visceral smooth muscles. One of the transmitters responsible for inhibitory neurotransmission has been reputed to be a purine, possibly ATP. However, the exact identity of this substance has never been verified. Here we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutafova-Yambolieva VN,Hwang SJ,Hao X,Chen H,Zhu MX,Wood JD,Ward SM,Sanders KM

更新日期：2007-10-09 00:00:00

abstract：:A paradigm of evolutionary biology is that adaptation and reproductive isolation are caused by a nearly infinite number of mutations of individually small effect. Here, we test this hypothesis by investigating the genetic basis of pollinator discrimination in two closely related species of monkeyflowers that differ in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schemske DW,Bradshaw HD Jr

更新日期：1999-10-12 00:00:00

abstract：:NADH:quinone oxidoreductase (complex I) plays a pivotal role in cellular energy production. It employs a series of redox cofactors to couple electron transfer to the generation of a proton-motive force across the inner mitochondrial or bacterial cytoplasmic membrane. Complex I contains a noncovalently bound flavin mon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev G,Reda T,Hirst J

更新日期：2007-07-31 00:00:00

abstract：:A fundamental question in the study of human language acquisition centers around apportioning explanatory force between the experience of the learner and the core knowledge that allows learners to represent that experience. We provide a previously unidentified kind of data identifying children's contribution to langua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han CH,Musolino J,Lidz J

更新日期：2016-01-26 00:00:00

abstract：:Smad proteins are key intracellular signaling effectors for the transforming growth factor-beta superfamily of peptide growth factors. Following receptor-induced activation, Smads move into the nucleus to activate transcription of a select set of target genes. The activity of Smad proteins must be tightly regulated to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Chang C,Gehling DJ,Hemmati-Brivanlou A,Derynck R

更新日期：2001-01-30 00:00:00

abstract：:The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams A,Lee GR,Spilianakis CG,Hwang SS,Eisenbarth SC,Flavell RA

更新日期：2013-04-23 00:00:00

abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheinfeldt LB,Soi S,Tishkoff SA

更新日期：2010-05-11 00:00:00

abstract：:The effect of metabolic depletion on the maturation-associated loss of membrane functions has been studied by using sheep reticulocytes incubated in vitro at 37 degrees C for periods up to 41 hr. ATP was either maintained with glucose, adenosine plus inosine, or depleted with 2-deoxyglucose plus arsenate. Two membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigensberg AM,Blostein R

更新日期：1983-08-01 00:00:00

abstract：:Transgenic crops producing Bacillus thuringiensis (Bt) toxins kill some key insect pests and thus can reduce reliance on insecticides. Widespread planting of such Bt crops increased concerns that their usefulness would be cut short by rapid evolution of resistance to Bt toxins by pests. Pink bollworm (Pectinophora gos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tabashnik BE,Dennehy TJ,Carrière Y

更新日期：2005-10-25 00:00:00

abstract：:Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson's disease (PD). We report that the Bin/Amphiphysin/Rvs (BAR) domain of protein interacting with PRKCA1 (PICK1) bound to the really interesting new gene 1 (RING1) domain of Parkin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He J,Xia M,Yeung PKK,Li J,Li Z,Chung KK,Chung SK,Xia J

更新日期：2018-07-24 00:00:00

abstract：:In adult rodents, neurons are continually generated in the subventricular zone of the forebrain, from where they migrate tangentially toward the olfactory bulb, the only known target for these neuronal precursors. Within the main olfactory bulb, they ascend radially into the granule and periglomerular cell layers, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gheusi G,Cremer H,McLean H,Chazal G,Vincent JD,Lledo PM

更新日期：2000-02-15 00:00:00

abstract：:Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rall LB,Pictet RL,Williams RH,Rutter WJ

更新日期：1973-12-01 00:00:00

abstract：:We identified the phosphatidylinositol transfer protein (PITP) as being responsible for a powerful latent, nucleotide-independent, Golgi-vesiculating activity that is present in the cytosol but is only manifested as an uncontrolled activity in a cytosolic protein subfraction, in which it is separated from regulatory c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon JP,Morimoto T,Bankaitis VA,Gottlieb TA,Ivanov IE,Adesnik M,Sabatini DD

更新日期：1998-09-15 00:00:00

abstract：:Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan P,Ripoll JJ,Wang R,Vuong L,Bailey-Steinitz LJ,Ye D,Crawford NM

更新日期：2017-02-28 00:00:00