Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells.

abstract：:In the central nervous system, glycogen-derived bioenergetic resources in astrocytes help promote tissue survival in response to focal neuronal stress. However, our understanding of the extent to which these resources are mobilized and utilized during neurodegeneration, especially in nearby regions that are not active...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper ML,Pasini S,Lambert WS,D'Alessandro KB,Yao V,Risner ML,Calkins DJ

更新日期：2020-08-04 00:00:00

abstract：:A protein methylation reaction involved in chemotaxis of Escherichia coli has been identified. The involvement of this reaction in chemotaxis in indicated by four lines of evidence. (a) The methylation reaction is altered in several classes of generally nonchemotactic mutants and is coreverted with the chemotaxis defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kort EN,Goy MF,Larsen SH,Adler J

更新日期：1975-10-01 00:00:00

abstract：:Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farruggio DC,Townsley FM,Ruderman JV

更新日期：1999-06-22 00:00:00

abstract：:Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melamed E,Hefti F,Wurtman RJ

更新日期：1980-07-01 00:00:00

abstract：:A Raleigh, NC, population of Drosophila melanogaster was sampled for the presence of enzyme null alleles at 25 loci. No nulls were found at any of five X-linked loci. Nulls were recovered at 13 of 20 autosomal loci; the weighted mean frequency for all 20 autosomal loci was estimated to be 0.0025. A consideration of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voelker RA,Langley CH,Brown AJ,Ohnishi S,Dickson B,Montgomery E,Smith SC

更新日期：1980-02-01 00:00:00

abstract：:We investigated the manner in which the sea urchin larva takes up calcium from its body cavity into the primary mesenchymal cells (PMCs) that are responsible for spicule formation. We used the membrane-impermeable fluorescent dye calcein and alexa-dextran, with or without a calcium channel inhibitor, and imaged the la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vidavsky N,Addadi S,Schertel A,Ben-Ezra D,Shpigel M,Addadi L,Weiner S

更新日期：2016-11-08 00:00:00

abstract：:Seismic magnitudes determined from surface and body waves for the Soviet underground nuclear explosion of September 14, 1988, are used to calculate the yield of that event from previously derived calibration curves. The yield obtained by combining the two seismic estimates is 113 kilotons, which is very close to those...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykes LR,Ekström G

更新日期：1989-05-01 00:00:00

abstract：:Alpha-Klotho (alpha-Kl) and its homolog, beta-Klotho (beta-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, members of the FGF19 subfamily, are believed to act as circulating metabolic regulators. Analyses of functional interactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomiyama K,Maeda R,Urakawa I,Yamazaki Y,Tanaka T,Ito S,Nabeshima Y,Tomita T,Odori S,Hosoda K,Nakao K,Imura A,Nabeshima Y

更新日期：2010-01-26 00:00:00

abstract：:In the plant Nicotiana plumbaginifolia, manganese superoxide dismutase (MnSOD) is synthesized in the cytoplasm as a preprotein and is subsequently translocated to the mitochondrial matrix with corresponding cleavage of an NH2-terminal leader sequence. To determine whether the plant enzyme could replace the endogenous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowler C,Alliotte T,Van den Bulcke M,Bauw G,Vandekerckhove J,Van Montagu M,Inzé D

更新日期：1989-05-01 00:00:00

abstract：:Development of in vitro resistance to HN2 (also called mustargen or mechlorethamine hydrochloride), N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), and cisplatin [cis-diamminedichloroplatinum(II)] was achieved in two human cell lines, the Raji/Burkitt lymphoma and a squamous cell carcinoma of the tongue. A 10- to 20-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei E 3rd,Cucchi CA,Rosowsky A,Tantravahi R,Bernal S,Ervin TJ,Ruprecht RM,Haseltine WA

更新日期：1985-04-01 00:00:00

abstract：:The impossibility theorems that abound in the theory of social choice show that there can be no satisfactory method for electing and ranking in the context of the traditional, 700-year-old model. A more realistic model, whose antecedents may be traced to Laplace and Galton, leads to a new theory that avoids all imposs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balinski M,Laraki R

更新日期：2007-05-22 00:00:00

abstract：:The functional architecture of mammalian visual cortex has been elucidated in impressive detail by experimental work of the past 20-25 years. The origin of many of the salient features of this architecture, however, has remained unexplained. This paper is the first of three (the others will appear in subsequent issues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linsker R

更新日期：1986-10-01 00:00:00

abstract：:We demonstrate the successful fabrication on CaF2 substrates of FeSe(1-x)Tex films with 0 ≤ x ≤ 1, including the region of 0.1 ≤ x ≤ 0.4, which is well known to be the "phase-separation region," via pulsed laser deposition that is a thermodynamically nonequilibrium method. In the resulting films, we observe a giant en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imai Y,Sawada Y,Nabeshima F,Maeda A

更新日期：2015-02-17 00:00:00

abstract：:Matching ATP:NADPH provision and consumption in the chloroplast is a prerequisite for efficient photosynthesis. In terms of ATP:NADPH ratio, the amount of ATP generated from the linear electron flow does not meet the demand of the Calvin-Benson-Bassham (CBB) cycle. Several different mechanisms to increase ATP availabi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voon CP,Guan X,Sun Y,Sahu A,Chan MN,Gardeström P,Wagner S,Fuchs P,Nietzel T,Versaw WK,Schwarzländer M,Lim BL

更新日期：2018-11-06 00:00:00

abstract：:Shell shape and shell thickness of the intertidal snail Littorina obtusata changed markedly between 1871 and 1984 in northern New England. Shells collected prior to 1900 were high-spired with thin walls, whereas shells collected in 1982-84 were low-spired with thick walls. An intertidal crab (Carcinus maenas) which pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeley RH

更新日期：1986-09-01 00:00:00

abstract：:Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Although the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. Because many questions rega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linnemann AK,O'Geen H,Keles S,Farnham PJ,Bresnick EH

更新日期：2011-08-16 00:00:00

abstract：:Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groudine M,Weintraub H

更新日期：1975-11-01 00:00:00

abstract：:Genetic studies of the white locus have shown that it has a distal region where structural mutations occur and a proximal region where regulatory mutations occur. To better understand the molecular basis of this genetic organization we have analyzed white locus transcription. A 2.7-kilobase transcript comprising 0.000...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'hare K,Levis R,Rubin GM

更新日期：1983-11-01 00:00:00

abstract：:The cingulate gyri in 37 subjects with and without early dementia of the Alzheimer type (DAT) were studied by using MRI at 1.0 mm3 isotropic resolution. Groups were segregated into young controls (n = 10), age-matched normal controls (n = 10), very mild DAT (n = 8), and mild DAT (n = 9). By using automated Bayesian se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MI,Hosakere M,Barker AR,Priebe CE,Lee N,Ratnanather JT,Wang L,Gado M,Morris JC,Csernansky JG

更新日期：2003-12-09 00:00:00

abstract：:The key enzyme for transcription of protein-encoding genes in eukaryotes is RNA polymerase II (RNAPII). The recruitment of this enzyme during transcription initiation and its passage along the template during transcription elongation is regulated through the association and dissociation of several complexes. Elongator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelissen H,Fleury D,Bruno L,Robles P,De Veylder L,Traas J,Micol JL,Van Montagu M,Inzé D,Van Lijsebettens M

更新日期：2005-05-24 00:00:00

abstract：:Calcium sensitivity of myosin cross-bridge activation in striated muscles commonly varies during ontogeny and in response to alterations in muscle usage, but the consequences for whole-organism physiology are not well known. Here we show that the relative abundances of alternatively spliced transcripts of the calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marden JH,Fitzhugh GH,Wolf MR,Arnold KD,Rowan B

更新日期：1999-12-21 00:00:00

abstract：:In flowering plants, the asymmetrical division of the zygote is the first hallmark of apical-basal polarity of the embryo and is controlled by a MAP kinase pathway that includes the MAPKKK YODA (YDA). In Arabidopsis, YDA is activated by the membrane-associated pseudokinase SHORT SUSPENSOR (SSP) through an unusual pare...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neu A,Eilbert E,Asseck LY,Slane D,Henschen A,Wang K,Bürgel P,Hildebrandt M,Musielak TJ,Kolb M,Lukowitz W,Grefen C,Bayer M

更新日期：2019-03-19 00:00:00

abstract：:The sense of body ownership represents a fundamental aspect of our self-awareness, but is disrupted in many neurological, psychiatric, and psychological conditions that are also characterized by disruption of skin temperature regulation, sometimes in a single limb. We hypothesized that skin temperature in a specific l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moseley GL,Olthof N,Venema A,Don S,Wijers M,Gallace A,Spence C

更新日期：2008-09-02 00:00:00

abstract：:A sequence-specific single-stranded DNA-binding protein from the trypanosomatid protozoan Crithidia fasciculata binds to a sequence of 12 nucleotides located at the origin of replication of kinetoplast DNA minicircles. This sequence, termed the universal minicircle sequence (UMS), is conserved in the kinetoplast DNA m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzfati Y,Abeliovich H,Kapeller I,Shlomai J

更新日期：1992-08-01 00:00:00

abstract：:Increasing interest in the role of the frontal lobe in relation to psychiatric and neurologic disorders has popularized tests of frontal function. One of these is the antisaccade task, in which both frontal lobe patients and schizophrenics are impaired despite normal performance on (pro)saccadic tasks. We used positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Driscoll GA,Alpert NM,Matthysse SW,Levy DL,Rauch SL,Holzman PS

更新日期：1995-01-31 00:00:00

abstract：:It is generally believed that the old quantum theory, as presented by Niels Bohr in 1913, fails when applied to few electron systems, such as the H(2) molecule. Here, we find previously undescribed solutions within the Bohr theory that describe the potential energy curve for the lowest singlet and triplet states of H(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Svidzinsky AA,Scully MO,Herschbach DR

更新日期：2005-08-23 00:00:00

abstract：:DNA fragments encoding the mouse steroid 21-hydroxylase (C21 or Cyp21A1) gene are de novo methylated when introduced into the mouse adrenocortical tumor cell line Y1 by DNA-mediated gene transfer. Although CCGG sequences within the C21 gene are de novo methylated, CCGG sites within flanking vector sequences, other mam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szyf M,Schimmer BP,Seidman JG

更新日期：1989-09-01 00:00:00

abstract：:There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotnoir-White D,El Ezzy M,Boulay PL,Rozendaal M,Bouvier M,Gagnon E,Mader S

更新日期：2018-03-13 00:00:00

abstract：:In adipocytes, adenylate cyclase is positively regulated by beta-adrenergic agents and negatively regulated by adenosine. Incubation of adipocytes with adenosine deaminase relieves the inhibition of adenylate cyclase by destroying the adenosine that the cells release into the medium. When adipocytes are incubated with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung FZ,Weber HW,Appleman MM

更新日期：1985-03-01 00:00:00

abstract：:Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hicks AM,Riedlinger G,Willingham MC,Alexander-Miller MA,Von Kap-Herr C,Pettenati MJ,Sanders AM,Weir HM,Du W,Kim J,Simpson AJ,Old LJ,Cui Z

更新日期：2006-05-16 00:00:00