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Successive-signal biasing for a learned sound sequence.

Abstract：

:Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the target A-B sequence was presented, the cortical "map" changed dynamically, specifically to exaggerate further the representation of the "anticipated" stimulus B. If B occurred, it was represented over a larger cortical area by more strongly excited, more coordinated, and more selectively responding neurons. This biasing peaked at the expected time of B onset with respect to A onset. No dynamic biasing of responses was recorded for any sound presented in a nontarget pair. Responses to nontarget frequencies flanking the representation of B were reduced in area and in response strength only after the presentation of A at the expected time of B onset. This study shows that cortical areas are not representationally static but, to the contrary, can be biased moment by moment in time as a function of behavioral context.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Zhou X,de Villers-Sidani E,Panizzutti R,Merzenich MM

doi

10.1073/pnas.1009433107

subject

Has Abstract

pub_date

2010-08-17 00:00:00

pages

14839-44

issue

33

eissn

0027-8424

issn

1091-6490

pii

1009433107

journal_volume

107

pub_type

杂志文章

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