Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

abstract：:The method of in situ hybridization has become a significant technique for specific-site chromosome mapping. We show that the resolution of in situ hybridization can be increased by hybridizing the probe to stretched prometaphase chromosomes with high-resolution banding obtained after 5-bromodeoxyuridine treatment of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabel BU,Naylor SL,Sakaguchi AY,Bell GI,Shows TB

更新日期：1983-11-01 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:Previous studies have identified human breast tumor particles possessing many of the features characteristic of RNA tumor viruses. In addition to the expected size (600 S) and density (1.16 g/ml) these include possession of an outer membrane and an inner one surrounding a "core" containing a DNA polymerase and a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Sweet RW,Dejak D,Spiegelman S

更新日期：1977-02-01 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spirochetes must migrate through complex, polymeric environments such as the basement membrane of the tick...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harman MW,Dunham-Ems SM,Caimano MJ,Belperron AA,Bockenstedt LK,Fu HC,Radolf JD,Wolgemuth CW

更新日期：2012-02-21 00:00:00

abstract：:Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors ( approximately 70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calin GA,Dumitru CD,Shimizu M,Bichi R,Zupo S,Noch E,Aldler H,Rattan S,Keating M,Rai K,Rassenti L,Kipps T,Negrini M,Bullrich F,Croce CM

更新日期：2002-11-26 00:00:00

abstract：:The gene encoding the receptor for hyaluronan-mediated motility (RHAMM) is overexpressed in many human cancers. However, it is unclear whether RHAMM plays a causal role in tumor initiation or progression. Using somatic gene transfer in a mouse model of islet cell tumorigenesis, we demonstrate that RHAMM isoform B (RHA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du YC,Chou CK,Klimstra DS,Varmus H

更新日期：2011-10-04 00:00:00

abstract：:Allostatic load (AL) is a measure of overall physiological wear-and-tear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health. To explo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barboza Solís C,Kelly-Irving M,Fantin R,Darnaudéry M,Torrisani J,Lang T,Delpierre C

更新日期：2015-02-17 00:00:00

abstract：:Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment of these metabolic electron carriers can be used to noninvasively monitor changes in metabolism, which is one of the hallmarks of carcinogenesis. This study combines cellular redox ratio, NADH and FAD lifetime, and subcellular m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skala MC,Riching KM,Gendron-Fitzpatrick A,Eickhoff J,Eliceiri KW,White JG,Ramanujam N

更新日期：2007-12-04 00:00:00

abstract：:Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection system, strandardized against fusion induced by Sendai virus. Correlation between the logarithm of virus dilution and the hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kidson C,Moreau MC,Asher DM,Brown PW,Coon HG,Gajdusek DC,Gibbs CJ Jr

更新日期：1978-06-01 00:00:00

abstract：:Monocytes originate from precursors made in the bone and remain in the circulation for nearly 24 h. Much effort has been done to identify the molecules regulating transendothelial migration of monocytes during inflammatory conditions. In contrast, considerably less is known about the process of constitutive monocyte e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Ecker S,Lindecke A,Hatzmann W,Kaltschmidt C,Zänker KS,Dittmar T

更新日期：2007-03-27 00:00:00

abstract：:CR1 is a short interspersed repetitive DNA element originally identified in the domestic chicken (Gallus gallus). However, unlike virtually all other such sequences described to date, CR1 is not confined to one or a few closely related species. It is probably a ubiquitous component of the avian genome, having been det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZQ,Ritzel RG,Lin CC,Hodgetts RB

更新日期：1991-07-01 00:00:00

abstract：:There are some ∼1,100 known antimicrobial peptides (AMPs), which permeabilize microbial membranes but have diverse sequences. Here, we develop a support vector machine (SVM)-based classifier to investigate ⍺-helical AMPs and the interrelated nature of their functional commonality and sequence homology. SVM is used to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EY,Fulan BM,Wong GC,Ferguson AL

更新日期：2016-11-29 00:00:00

abstract：:The effect of human papillomavirus (HPV) and activated oncogenes on the growth and morphology of primary baby mouse kidney (BMK) cells has been studied. Early region DNA from HPV types 16, 18, 31, and 33, but not type 6, under the transcriptional control of a heterologous, retroviral promoter cooperated with EJ-ras to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crook T,Storey A,Almond N,Osborn K,Crawford L

更新日期：1988-12-01 00:00:00

abstract：:Release of formylmethionine from the reticulocyte ribosomal substrate, f[(3)H]Met-tRNA.ribosome, is promoted by reticulocyte release factor (RF). The initial rate of this reaction is stimulated by GTP but inhibited by GDPCP. Formation of an RF.UA[(3)H]A(2).ribosome complex is a measure of the binding of reticulocyte R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate WP,Beaudet AL,Caskey CT

更新日期：1973-08-01 00:00:00

abstract：:Among 21 human mammary tumors analyzed for transforming genes by transfection of NIH/3T3 cells, only DNA of a carcinosarcoma cell line, HS578T, registered as positive. A Harvey (H)-ras oncogene identified in this line was cloned in biologically active form and the activating lesion was identified as a single nucleotid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus MH,Yuasa Y,Aaronson SA

更新日期：1984-09-01 00:00:00

abstract：:SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes within Salmonella pathogenicity island 2 (SPI-2). As expression of the SsrB protein is promoted by se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi J,Shin D,Yoon H,Kim J,Lee CR,Kim M,Seok YJ,Ryu S

更新日期：2010-11-23 00:00:00

abstract：:The sequence of the cloned Bacillus amyloliquefaciens subtilisin gene suggested that this secreted serine protease is produced as a larger precursor, designated preprosubtilisin [Wells, J. A., Ferrari, E., Henner, D. J., Estell, D. A. & Chen, E. Y. (1983) Nucleic Acids Res. 11, 7911-7925]. Biochemical evidence present...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power SD,Adams RM,Wells JA

更新日期：1986-05-01 00:00:00

abstract：:[3H]Forskolin bound to high- and low-affinity sites in the rat brain. The high-affinity site was discretely located, with highest densities in the striatum, nucleus accumbens, olfactory tubercule, substantia nigra, hippocampus, and the molecular layers of the cerebellum. This site did not correlate well with the distr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poat JA,Cripps HE,Iversen LL

更新日期：1988-05-01 00:00:00

abstract：:Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CS,Hsu SJ,Chen HC,Tseng TC,Liu CH,Niu WF,Jeng J,Liu CJ,Lai MY,Chen PJ,Kao JH,Chen DS

更新日期：2011-03-01 00:00:00

abstract：:DNA barcoding systems employ a short, standardized gene region to identify species. A 648-bp segment of mitochondrial cytochrome c oxidase 1 (CO1) is the core barcode region for animals, but its utility has not been tested in fungi. This study began with an examination of patterns of sequence divergences in this gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert KA,Samson RA,Dewaard JR,Houbraken J,Lévesque CA,Moncalvo JM,Louis-Seize G,Hebert PD

更新日期：2007-03-06 00:00:00

abstract：:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efendić S,Wajngot A,Cerasi E,Luft R

更新日期：1980-12-01 00:00:00

abstract：:Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one allele is "active"; the other, "silent" allele contains an amber termination codon. The rate of reversion of this amber codon was determined to be 0.3-1 X 10(-4) pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wabl M,Burrows PD,von Gabain A,Steinberg C

更新日期：1985-01-01 00:00:00

abstract：:The prediction of binding sites and the understanding of interfaces associated with protein complexation remains an open problem in molecular biophysics. This work shows that a crucial factor in predicting and rationalizing protein-protein interfaces can be inferred by assessing the extent of intramolecular desolvatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Scheraga HA

更新日期：2003-01-07 00:00:00

abstract：:WIN antiviral compounds bind human rhinovirus, as well as enterovirus and parechovirus, in an internal cavity located within the viral protein capsid. Access to the buried pocket necessitates deviation from the average viral protein structure identified by crystallography. We investigated the dissociation of WIN 52084...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhou Z,Post CB

更新日期：2005-05-24 00:00:00

abstract：:The charge-stabilization effect associated with alpha-helices in proteins has been reexamined by microscopic calculations without any a priori assumptions about the dielectric constant of the protein. The calculations reproduce the observed charge stabilization effect of a helix in two well-defined test cases: a histi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aqvist J,Luecke H,Quiocho FA,Warshel A

更新日期：1991-03-01 00:00:00

abstract：:Posttranscriptional RNA regulation is important in determining the plasticity of cellular phenotypes. However, mechanisms of how RNA binding proteins (RBPs) influence cellular behavior are poorly understood. We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also know as HuR) regulates the alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SH,Elemento O,Zhang J,Zhuang ZW,Simons M,Hla T

更新日期：2014-12-23 00:00:00