Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish.

abstract：:A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H2O2 caused phenomena of methionine oxidation and droplet melting that were rever...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Y,Zhou X,Kato M,Liu D,Ghaemmaghami S,Tu BP,McKnight SL

更新日期：2020-11-17 00:00:00

abstract：:In the primary visual cortex (V1) of many mammalian species, neurons are spatially organized according to their preferred orientation into a highly ordered map. However, whether and how the various presynaptic inputs to V1 neurons are organized relative to the neuronal orientation map remain unclear. To address this i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang QF,Li H,Chen M,Guo A,Wen Y,Poo MM

更新日期：2018-05-29 00:00:00

abstract：:The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. AT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muallem S,Schoeffield M,Pandol S,Sachs G

更新日期：1985-07-01 00:00:00

abstract：:The complete nucleotide sequences of the cDNAs encoding the heavy- and light-chain variable regions (VH and VL) of myeloma protein W3129, an anti-alpha(1----6)-dextran with a unique combining site, have been determined. The VH region is encoded by a germ-line gene highly homologous to VH441, which also appears to be u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borden P,Kabat EA

更新日期：1987-04-01 00:00:00

abstract：:Ribonuclease H (EC 3.1.4.34) has been used to remove selectively much of the 3'-terminal poly(adenylic acid) [poly(A)] from poliovirus RNA by treating the RNA with the enzyme in the presence of poly(dT). Over 80% of the poly(A) could be removed and the residuum was found as oligo(A) stretches attached to many or all o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector DH,Baltimore D

更新日期：1974-08-01 00:00:00

abstract：:C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a beta-amino acid, and a benzoxazolinate moiety. We now show that the benzoxazolinate moiety is derived from chorismate by the sequential action of two enzymes-SgcD, a 2-amino-2-deoxyisochorismate (ADIC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Lanen SG,Lin S,Shen B

更新日期：2008-01-15 00:00:00

abstract：:NADH:quinone oxidoreductase (complex I) plays a pivotal role in cellular energy production. It employs a series of redox cofactors to couple electron transfer to the generation of a proton-motive force across the inner mitochondrial or bacterial cytoplasmic membrane. Complex I contains a noncovalently bound flavin mon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev G,Reda T,Hirst J

更新日期：2007-07-31 00:00:00

abstract：:Translational initiation factor 2 (IF2) is a guanine nucleotide-binding protein that can bind guanosine 3',5'-(bis) diphosphate (ppGpp), an alarmone involved in stringent response in bacteria. In cells growing under optimal conditions, the GTP concentration is very high, and that of ppGpp very low. However, under stre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milon P,Tischenko E,Tomsic J,Caserta E,Folkers G,La Teana A,Rodnina MV,Pon CL,Boelens R,Gualerzi CO

更新日期：2006-09-19 00:00:00

abstract：:Total heterogeneous nuclear RNA from HeLa cells infected with adenovirus for 18-20 hr stimulates amino acid incorporation into protein in a cell-free system from Ehrlich ascites tumors. This stimulation of protein synthesis by the nuclear RNA requires intact nuclei. The role of nuclei in this system is unknown, but ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee NK,Weissbach H

更新日期：1974-08-01 00:00:00

abstract：:Replication through damaged sites in DNA requires in Escherichia coli the SOS stress-inducible DNA polymerase V (UmuC), which is specialized for lesion bypass. Homologs of the umuC gene were found on native conjugative plasmids, which often carry multiple antibiotic-resistant genes. MucB is a UmuC homolog present on p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith M,Sarov-Blat L,Livneh Z

更新日期：2000-10-10 00:00:00

abstract：:The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in healthy young men. Regional cerebral blood flow was measured by positron emission tomography and bolus injections of H2(15)O, while subjects performed face matching,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haxby JV,Grady CL,Horwitz B,Ungerleider LG,Mishkin M,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1991-03-01 00:00:00

abstract：:We reveal that the aragonite CaCO3 platelets in nacre of Haliotis laevigata are covered with a continuous layer of disordered amorphous CaCO3 and that there is no protein interaction with this layer. This finding contradicts classical paradigms of biomineralization, e.g., an epitaxial match between the structural orga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassif N,Pinna N,Gehrke N,Antonietti M,Jäger C,Cölfen H

更新日期：2005-09-06 00:00:00

abstract：:Porphyromonas gingivalis is the major causative agent of periodontitis, and it may also be involved in the development of systemic diseases (atherosclerosis, rheumatoid arthritis). P. gingivalis is found on and within oral and gingival epithelial cells following binding to surface components of host cells, which serve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boisvert H,Lorand L,Duncan MJ

更新日期：2014-04-08 00:00:00

abstract：:Genetic analysis for group selection is developed for the case of a biallelic locus (A, a) undergoing group selection of founder populations only. By contrast to R. Levins"E = E(x) models, extinction now depends on genetics at the propagule stage but acts uniformly on larger populations. Biological evidence supports t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boorman SA

更新日期：1978-04-01 00:00:00

abstract：:In polyandrous species, fathers benefit from attracting greater maternal investment toward their offspring at the expense of the offspring of other males, while mothers should usually allocate resources equally among offspring. This conflict can lead to an evolutionary arms race between the sexes, manifested through a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raunsgard A,Opedal ØH,Ekrem RK,Wright J,Bolstad GH,Armbruster WS,Pélabon C

更新日期：2018-11-06 00:00:00

abstract：:In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-gamma). We tested the hypothesis that the imbalance of these gene products reflects skewed expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra N,Brown DR,Olorenshaw IM,Kammer GM

更新日期：2001-02-27 00:00:00

abstract：:Ubiquitination, the crucial posttranslational modification that regulates the eukaryotic proteome, is carried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase). Although most E2s can work with any of the three mechanistically distinct classes of E3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dove KK,Kemp HA,Di Bona KR,Reiter KH,Milburn LJ,Camacho D,Fay DS,Miller DL,Klevit RE

更新日期：2017-08-08 00:00:00

abstract：:Cell clones nonproductively transformed by the replication-defective Abelson strain of murine leukemia virus (AbLV) were analyzed for type C viral antigen expression by competition immunoassay. AbLV-transformed mink non-producer lines were found to express a 110,000- to 130,000-molecular weight polyprotein containing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds FH Jr,Sacks TL,Deobagkar DN,Stephenson JR

更新日期：1978-08-01 00:00:00

abstract：:Humans readily form social impressions, such as attractiveness and trustworthiness, from a stranger's facial features. Understanding the provenance of these impressions has clear scientific importance and societal implications. Motivated by the efficient coding hypothesis of brain representation, as well as Claude Sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryali CK,Goffin S,Winkielman P,Yu AJ

更新日期：2020-11-24 00:00:00

abstract：:The translocation of lipids from the inner to the outer membrane of Escherichia coli has been investigated by pulse-chase experiments. After a pulse with [2-3H]glycerol, the specific activity of the newly synthesized [3H]phosphatidylethanolamine was 5 times greater in the inner than in the outer membrane. During the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donohue-Rolfe AM,Schaechter M

更新日期：1980-04-01 00:00:00

abstract：:For an excitable cell to function properly, a precise number of ion channel proteins need to be trafficked to distinct locations on the cell surface membrane, through a network and anchoring activity of cytoskeletal proteins. Not surprisingly, mutations in anchoring proteins have profound effects on membrane excitabil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rafizadeh S,Zhang Z,Woltz RL,Kim HJ,Myers RE,Lu L,Tuteja D,Singapuri A,Bigdeli AA,Harchache SB,Knowlton AA,Yarov-Yarovoy V,Yamoah EN,Chiamvimonvat N

更新日期：2014-07-08 00:00:00

abstract：:Cyber conflict is now a common and potentially dangerous occurrence. The target typically faces a strategic choice based on its ability to attribute the attack to a specific perpetrator and whether it has a viable punishment at its disposal. We present a game-theoretic model, in which the best strategic choice for the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards B,Furnas A,Forrest S,Axelrod R

更新日期：2017-03-14 00:00:00

abstract：:The minimal size of the recombination site required for efficient FLP recombinase-catalyzed recombination in vitro is no more than 28 base pairs, which includes parts of two 13-base-pair inverted repeats and all of an 8-base-pair spacer. The FLP recombinase cleaves the DNA at the boundaries of the spacer, becomes cova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senecoff JF,Bruckner RC,Cox MM

更新日期：1985-11-01 00:00:00

abstract：:We have found that the bacterial transposon Tn7 can recognize and preferentially insert adjacent to triple-helical nucleic acid structures. Both synthetic intermolecular triplexes, formed through the pairing of a short triplex-forming oligonucleotide on a plasmid DNA, and naturally occurring mirror repeat sequences kn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao JE,Miller PS,Craig NL

更新日期：2000-04-11 00:00:00

abstract：:Secretion of extracellular polymeric substances (EPSs) by growing bacteria is an integral part of forming biofilm-like structures. In such dense systems, mechanical interactions among the structural components can be expected to significantly contribute to morphological properties. Here, we use a particle-based modeli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghosh P,Mondal J,Ben-Jacob E,Levine H

更新日期：2015-04-28 00:00:00

abstract：:Strategies to elicit Abs that can neutralize diverse strains of a highly mutable pathogen are likely to result in a potent vaccine. Broadly neutralizing Abs (bnAbs) against HIV have been isolated from patients, proving that the human immune system can evolve them. Using computer simulations and theory, we study immuni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer JS,Moore PL,Kardar M,Chakraborty AK

更新日期：2016-11-08 00:00:00

abstract：:Cells in the brain act as components of extended networks. Therefore, to understand neurobiological processes in a physiological context, it is essential to study them in vivo. Super-resolution microscopy has spatial resolution beyond the diffraction limit, thus promising to provide structural and functional insights ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turcotte R,Liang Y,Tanimoto M,Zhang Q,Li Z,Koyama M,Betzig E,Ji N

更新日期：2019-05-07 00:00:00

abstract：:The counterintuitive features of quantum physics challenge many common-sense assumptions. In an interferometric quantum eraser experiment, one can actively choose whether or not to erase which-path information (a particle feature) of one quantum system and thus observe its wave feature via interference or not by perfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma XS,Kofler J,Qarry A,Tetik N,Scheidl T,Ursin R,Ramelow S,Herbst T,Ratschbacher L,Fedrizzi A,Jennewein T,Zeilinger A

更新日期：2013-01-22 00:00:00

abstract：:Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin HK,Yeh S,Kang HY,Chang C

更新日期：2001-06-19 00:00:00

abstract：:Lithium ion at concentrations between 2 and 20 mM simulated the stimulatory effects of insulin on the uptake of alpha-aminoisobutyric acid, synthesis of RNA and DNA, and cell multiplication in mouse mammary gland explants cultured in a chemically defined synthetic medium. Other monovalent cations were virtually ineffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hori C,Oka T

更新日期：1979-06-01 00:00:00