The nucleotide-binding site of bacterial translation initiation factor 2 (IF2) as a metabolic sensor.

abstract：:The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the occurrence of desm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halberg RB,Katzung DS,Hoff PD,Moser AR,Cole CE,Lubet RA,Donehower LA,Jacoby RF,Dove WF

更新日期：2000-03-28 00:00:00

abstract：:Genome duplication followed by massive gene loss has permanently shaped the genomes of many higher eukaryotes, particularly angiosperms. It has long been believed that a primary advantage of genome duplication is the opportunity for the evolution of genes with new functions by modification of duplicated genes. If so, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chapman BA,Bowers JE,Feltus FA,Paterson AH

更新日期：2006-02-21 00:00:00

abstract：:Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology has never been firmly established. Here, we present compelling evidence that elastin, the key ECM protein found in connective tissues, is ferroelectric, and we elucidate the molecular mechanism of i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Cai HL,Zelisko M,Wang Y,Sun J,Yan F,Ma F,Wang P,Chen QN,Zheng H,Meng X,Sharma P,Zhang Y,Li J

更新日期：2014-07-08 00:00:00

abstract：:Hepatitis C virus (HCV) NS3-4A is a membrane-associated multifunctional protein harboring serine protease and RNA helicase activities. It is an essential component of the HCV replication complex and a prime target for antiviral intervention. Here, we show that membrane association and structural organization of HCV NS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brass V,Berke JM,Montserret R,Blum HE,Penin F,Moradpour D

更新日期：2008-09-23 00:00:00

abstract：:Policy folklists present a set of alleged historical facts seen as relevant to some social issue. Although the validity of these folklists is dubious, leaders and writers circulate them in the media, variants arise, and the lists continue on, sometimes for decades. Folklists are repeated because their messages are app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill B

更新日期：2014-07-22 00:00:00

abstract：:B-G antigens are cell-surface molecules encoded by a highly polymorphic multigene family located in the chicken major histocompatibility complex (MHC). Rabbit antisera to B-G molecules immunoprecipitate 3-6 bands from iodinated erythrocytes by sodium dodecyl sulfate (SDS) gels under reducing conditions. These are all ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Salomonsen J,Skjødt K,Thorpe D

更新日期：1990-11-01 00:00:00

abstract：:The structural gene for plasmid-mediated ampicillin resistance resides upon a 3.2 X 10(6) dalton transposable sequence (TnA) flanked by short inverted repeated sequences that accompany its insertion. TnA was transposed to pMB8, a 1.8 X 10(6) dalton derivative of the colicingenic plasmid ColE1. Random deletions were in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffron F,Bedinger P,Champoux JJ,Falkow S

更新日期：1977-02-01 00:00:00

abstract：:Cellular communities in living tissues act in concert to establish intricate microenvironments, with complexity difficult to recapitulate in vitro. We report a method for docking numerous cellularized hydrogel shapes (100-1,000 µm in size) into hydrogel templates to construct 3D cellular microenvironments. Each shape ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eng G,Lee BW,Parsa H,Chin CD,Schneider J,Linkov G,Sia SK,Vunjak-Novakovic G

更新日期：2013-03-19 00:00:00

abstract：:Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fails to eradicate mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rassenti LZ,Balatti V,Ghia EM,Palamarchuk A,Tomasello L,Fadda P,Pekarsky Y,Widhopf GF 2nd,Kipps TJ,Croce CM

更新日期：2017-10-03 00:00:00

abstract：:Oligosaccharide moieties of cell-surface glycoconjugates are thought to be involved in recognition events associated with tumor metastasis and invasion. Using swainsonine (SW), an inhibitor of Golgi alpha-mannosidase II that results in the formation of hybrid-type oligosaccharides on N-linked glycoproteins, we have te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Humphries MJ,Matsumoto K,White SL,Olden K

更新日期：1986-03-01 00:00:00

abstract：:The circadian clock in eukaryotes controls transcriptional and posttranscriptional events, including regulation of the levels and phosphorylation state of translation factors. However, the mechanisms underlying clock control of translation initiation, and the impact of this potential regulation on rhythmic protein syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karki S,Castillo K,Ding Z,Kerr O,Lamb TM,Wu C,Sachs MS,Bell-Pedersen D

更新日期：2020-05-19 00:00:00

abstract：:Although adaptor ADAP (FYB) and its binding to SLP-76 has been implicated in TcR-induced "inside-out" signaling for LFA-1 activation in T cells, little is known regarding its role in LFA-1-mediated "outside-in" signaling. In this study, we demonstrate that ADAP and SLP-76-ADAP binding are coupled to LFA-1 costimulatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Wei B,Bismuth G,Rudd CE

更新日期：2009-07-28 00:00:00

abstract：:The integrity of cell membranes is maintained by a balance between the amount of cholesterol and the amounts of unsaturated and saturated fatty acids in phospholipids. This balance is maintained by membrane-bound transcription factors called sterol regulatory element-binding proteins (SREBPs) that activate genes encod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown MS,Goldstein JL

更新日期：1999-09-28 00:00:00

abstract：:Protein database searches frequently can reveal biologically significant sequence relationships useful in understanding structure and function. Weak but meaningful sequence patterns can be obscured, however, by other similarities due only to chance. By searching a database for multiple as opposed to pairwise alignment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altschul SF,Lipman DJ

更新日期：1990-07-01 00:00:00

abstract：:Malignant B lymphocytes from several patients with chronic lymphocytic leukemia (CLL) were examined for reactivity with murine monoclonal antibody 17.109. This antibody, prepared against the rheumatoid factor (RF) paraprotein Sie, recognizes a crossreactive idiotype on 48% of human IgM RF paraproteins, but does not re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipps TJ,Fong S,Tomhave E,Chen PP,Goldfien RD,Carson DA

更新日期：1987-05-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) preparations contain activity against HIV type 1 (HIV-1). However, there has been controversy about whether some biological activities of hCG beta-subunit (hCGbeta) preparations are caused by the beta-subunit itself or other proteins present in the preparations. We report here the pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee-Huang S,Huang PL,Sun Y,Huang PL,Kung HF,Blithe DL,Chen HC

更新日期：1999-03-16 00:00:00

abstract：:Most humans in the United States have been infected with BK virus (BKV), a human papovavirus. Because BKV has oncogenic properties, we have investigated whether it may be a cause of human cancer. Basic principles of tumor virology imply that BKV-induced tumors should contain BKV DNA sequences. Therefore, we assayed (b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wold WS,Mackey JK,Brackmann KH,Takemori N,Rigden P,Green M

更新日期：1978-01-01 00:00:00

abstract：:The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harki DA,Satyamurthy N,Stout DB,Phelps ME,Dervan PB

更新日期：2008-09-02 00:00:00

abstract：:A glycoprotein, termed amphiregulin (AR), inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. It has been purified to apparent homogeneity from serum-free conditioned medium of MCF-7 human breast carcinoma cells that had been trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shoyab M,McDonald VL,Bradley JG,Todaro GJ

更新日期：1988-09-01 00:00:00

abstract：:Nuclear factor kappaB (NF-kappaB) transcription factors regulate genes responsible for critical cellular processes. IkappaBalpha, -beta, and -epsilon bind to NF-kappaBs and inhibit their transcriptional activity. The NF-kappaB-binding domains of IkappaBs contain six ankyrin repeats (ARs), which adopt a beta-hairpin/al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truhlar SM,Torpey JW,Komives EA

更新日期：2006-12-12 00:00:00

abstract：:Formation and remodeling of the skeleton relies on precise temporal and spatial regulation of genes expressed in cartilage and bone cells. Debilitating diseases of the skeletal system occur when mutations arise that disrupt these intricate genetic regulatory programs. Here, we report that mice bearing parallel null mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones DC,Schweitzer MN,Wein M,Sigrist K,Takagi T,Ishii S,Glimcher LH

更新日期：2010-05-04 00:00:00

abstract：:Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub-100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malý P,Gruber JM,Cogdell RJ,Mančal T,van Grondelle R

更新日期：2016-03-15 00:00:00

abstract：:In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2003-11-25 00:00:00

abstract：:During cytokinesis, a cleavage furrow generated by actomyosin ring contraction is restructured into the midbody, a platform for the assembly of the abscission machinery that controls the final separation of daughter cells. The polymerization state of F-actin is important during assembly, ingression, disassembly, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terry SJ,Donà F,Osenberg P,Carlton JG,Eggert US

更新日期：2018-02-27 00:00:00

abstract：:Many bacterial pathogens of plants and animals have evolved a specialized protein-secretion system termed type III to deliver bacterial proteins into host cells. These proteins stimulate or interfere with host cellular functions for the pathogen's benefit. The Salmonella typhimurium pathogenicity island 1 encodes one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kubori T,Sukhan A,Aizawa SI,Galán JE

更新日期：2000-08-29 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally decline with aging. Deple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Stein LR,Kim D,Ho K,Yu GQ,Zhan L,Larsson TE,Mucke L

更新日期：2018-11-27 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for metastatic hormone-sensitive prostate cancer for more than 70 y. Chemotherapy has been reserved for metastatic castration-resistant pros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komura K,Jeong SH,Hinohara K,Qu F,Wang X,Hiraki M,Azuma H,Lee GS,Kantoff PW,Sweeney CJ

更新日期：2016-05-31 00:00:00

abstract：:NAPVSIPQ (NAP), an active fragment of the glial-derived activity-dependent neuroprotective protein, is protective at femtomolar concentrations against a wide array of neural insults and prevents ethanol-induced fetal wastage and growth retardation in mice. NAP also antagonizes ethanol inhibition of L1-mediated cell ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilkemeyer MF,Chen SY,Menkari CE,Brenneman DE,Sulik KK,Charness ME

更新日期：2003-07-08 00:00:00

abstract：:Based on the analysis of genomic DNA from single healthy animals of each of five primate species, nucleotide and predicted amino acid sequences of the infectious amyloid precursor gene of higher apes (Gorilla and Pan) and Old World (Macaca) and New World (Ateles, Saimiri) monkeys showed 95-99% homology to the human se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cervenáková L,Brown P,Goldfarb LG,Nagle J,Pettrone K,Rubenstein R,Dubnick M,Gibbs CJ Jr,Gajdusek DC

更新日期：1994-12-06 00:00:00