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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Abstract：

:Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Ser-790. A mutation at AR Ser-210 results in the reversal of Akt-mediated suppression of AR transactivation. Activation of the phosphatidylinositol-3-OH kinase/Akt pathway results in the suppression of AR target genes, such as p21, and the decrease of androgen/AR-mediated apoptosis, which may involve the inhibition of interaction between AR and AR coregulators. Together, these findings provide a molecular basis for cross-talk between two signaling pathways at the level of Akt and AR-AR coregulators that may help us to better understand the roles of Akt in the androgen/AR-mediated apoptosis.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Lin HK,Yeh S,Kang HY,Chang C

doi

10.1073/pnas.121173298

keywords:

subject

Has Abstract

pub_date

2001-06-19 00:00:00

pages

7200-5

issue

13

eissn

0027-8424

issn

1091-6490

pii

121173298

journal_volume

98

pub_type

杂志文章

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