Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.

abstract：:Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akamatsu Y,Dziadkowiec D,Ikeguchi M,Shinagawa H,Iwasaki H

更新日期：2003-12-23 00:00:00

abstract：:Skeletal muscle cells have served as a paradigm for understanding mechanisms leading to cellular differentiation. The proliferation and differentiation of muscle precursor cells require the concerted activity of myogenic regulatory factors including MyoD. In addition, chromatin modifiers mediate dynamic modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling BM,Bharathy N,Chung TK,Kok WK,Li S,Tan YH,Rao VK,Gopinadhan S,Sartorelli V,Walsh MJ,Taneja R

更新日期：2012-01-17 00:00:00

abstract：:Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the actinobacterial symbionts of fungus-growing ants, we discovered a small family of three previously unreported piperazic acid-containing cyclic depsipeptides, gerumycins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sit CS,Ruzzini AC,Van Arnam EB,Ramadhar TR,Currie CR,Clardy J

更新日期：2015-10-27 00:00:00

abstract：:HIV-1 maturation involves conversion of the immature Gag polyprotein lattice, which lines the inner surface of the viral membrane, to the mature capsid protein (CA) lattice, which encloses the viral RNA. Maturation inhibitors such as bevirimat (BVM) bind within six-helix bundles, formed by a segment that spans the jun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Louis JM,Tycko R

更新日期：2020-05-12 00:00:00

abstract：:We have identified a major T-cell epitope, amino acids 48-54 (DRAHYNI, in one-letter code) in the E7 open reading frame protein of human papillomavirus (HPV) type 16. Lymph node cells from mice immunized with synthetic peptides containing DRAHYNI proliferated and produced interleukin when challenged in vitro with pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tindle RW,Fernando GJ,Sterling JC,Frazer IH

更新日期：1991-07-01 00:00:00

abstract：:Replication of the murine leukemia viruses is strongly suppressed in mouse embryonic stem (ES) cells. Proviral DNAs are formed normally but are then silenced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809. We show here that ZFP809 expression is not regulated by transcription but rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Goff SP

更新日期：2017-02-07 00:00:00

abstract：:Inadequate resolution is the principal limitation of radiocarbon dating. However, recent work has shown that exact-year precision is attainable if use can be made of past increases in atmospheric radiocarbon concentration or so-called Miyake events. Here, this nascent method is applied to an archaeological site of pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuitems M,Panin A,Scifo A,Arzhantseva I,Kononov Y,Doeve P,Neocleous A,Dee M

更新日期：2020-06-23 00:00:00

abstract：:The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chorny A,Gonzalez-Rey E,Fernandez-Martin A,Pozo D,Ganea D,Delgado M

更新日期：2005-09-20 00:00:00

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:Nitric oxide (NO) has been implicated as a pathogenic mediator in a variety of central nervous system (CNS) disease states, including the animal model of multiple sclerosis (MS) and experimental allergic encephalomyelitis. We have examined post-mortem brain tissues collected from patients previously diagnosed with MS,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bagasra O,Michaels FH,Zheng YM,Bobroski LE,Spitsin SV,Fu ZF,Tawadros R,Koprowski H

更新日期：1995-12-19 00:00:00

abstract：:The geographical structure of a population distributed continuously and homogeneously along an infinite linear habitat is explored. The analysis is restricted to a single locus in the absence of selection, and every mutant is assumed to be new to the population. An explicit formula is derived for the probability that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagylaki T

更新日期：1974-08-01 00:00:00

abstract：:In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindstrom DM,Drake JW

更新日期：1970-03-01 00:00:00

abstract：:We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught mosquitoes from three tropical sites, two in Cameroon (Simbock and Tibati, separated by 320 km) and one in Kenya (Rota, >2,000 k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Annan Z,Durand P,Ayala FJ,Arnathau C,Awono-Ambene P,Simard F,Razakandrainibe FG,Koella JC,Fontenille D,Renaud F

更新日期：2007-05-08 00:00:00

abstract：:Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively. Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and have iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi YH,Westfield GH,Oleskie AN,Trievel RC,Shilatifard A,Skiniotis G

更新日期：2011-12-20 00:00:00

abstract：:Highly purified RNA polymerase II was found to be able to weakly recognize the initiator (Inr) present in the adenovirus IVa2 and major late promoters. The association of RNA polymerase II with the Inr was enhanced by the general transcription factors. The Inr was capable of directing the formation of a DNA-protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo J,Buckbinder L,Reinberg D

更新日期：1991-09-15 00:00:00

abstract：:Undesired side products of DNA transfections are usually discarded. However, here, we show that such products may provide insight into mutational events that are also a major driving force in protein evolution. While studying the small heat-shock protein alphaA-crystallin, we transfected the hamster alphaA-crystallin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Rijk AA,de Jong WW,Bloemendal H

更新日期：1999-07-06 00:00:00

abstract：:Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the survival of NK-22 cells and IL-22 production in response to IL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cella M,Otero K,Colonna M

更新日期：2010-06-15 00:00:00

abstract：:The apparent failure of infants to understand "object permanence" by reaching for hidden objects is perhaps the most striking and debated phenomenon in cognitive development. Of particular interest is the extent to which infants perceive and remember objects in a similar way to that of adults. Here we report two findi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Csibra G,Johnson MH

更新日期：2005-10-18 00:00:00

abstract：:A yeast gene has been identified by screening for DNA replication mutants using a permeabilized cell replication assay. The mutant is temperature sensitive for growth and shows a cell cycle phenotype typical of DNA replication mutants. RNA synthesis is normal in the mutant but DNA synthesis ceases upon shift to the no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budd ME,Campbell JL

更新日期：1995-08-15 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorgun G,Ramsay AG,Holderried TA,Zahrieh D,Le Dieu R,Liu F,Quackenbush J,Croce CM,Gribben JG

更新日期：2009-04-14 00:00:00

abstract：:We have isolated rat brain cDNA clones encoding AE2, a homologue of the erythrocyte anion exchanger, band 3 (AE1). Immunocytochemistry and in situ hybridization reveal that, in brain, AE2 expression is restricted to the basolateral membrane of the choroid plexus epithelium. Expression of a full-length mouse AE2 cDNA i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindsey AE,Schneider K,Simmons DM,Baron R,Lee BS,Kopito RR

更新日期：1990-07-01 00:00:00

abstract：:Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern BC,Halpern RM,Chaney SQ,Smith RA

更新日期：1970-12-01 00:00:00

abstract：:The Na/K pump is a P-type ATPase that exchanges three intracellular Na(+) ions for two extracellular K(+) ions through the plasmalemma of nearly all animal cells. The mechanisms involved in cation selection by the pump's ion-binding sites (site I and site II bind either Na(+) or K(+); site III binds only Na(+)) are po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratheal IM,Virgin GK,Yu H,Roux B,Gatto C,Artigas P

更新日期：2010-10-26 00:00:00

abstract：:Rhizobium meliloti strain SU47 produces the calcofluor-binding exopolysaccharide, succinoglycan, that is required for alfalfa root nodule invasion. Strains derived from R. meliloti SU47 secreted an acidic exopolysaccharide, EPSb, that replaced succinoglycan in nodule invasion. EPSb, which has not formerly been identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhan HJ,Levery SB,Lee CC,Leigh JA

更新日期：1989-05-01 00:00:00

abstract：:Pokeweed antiviral protein (PAP), a 29-kDa protein isolated from Phytolacca americana, inhibits translation by catalytically removing a specific adenine residue from the large rRNA of the 60S subunit of eukaryotic ribosomes. In addition to its ribosome-inactivating ability, PAP has potent antiviral activity against ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tumer NE,Hwang DJ,Bonness M

更新日期：1997-04-15 00:00:00

abstract：:It is demonstrated that, properly represented, the amino acid composition of protein sequences contains the information necessary to delineate the global properties of protein structure space. A numerical representation of amino acid sequence in terms of a set of property factors is used, and the values of those prope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：2009-08-25 00:00:00

abstract：:Symbiotic microbes impact the severity of a variety of diseases through regulation of T-cell development. However, little is known regarding the molecular mechanisms by which this is accomplished. Here we report that a secreted factor, Erdr1, is regulated by the microbiota to control T-cell apoptosis. Erdr1 expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soto R,Petersen C,Novis CL,Kubinak JL,Bell R,Stephens WZ,Lane TE,Fujinami RS,Bosque A,O'Connell RM,Round JL

更新日期：2017-05-23 00:00:00

abstract：:Many pathogenic bacteria produce extracellular DNase, but the benefit of this enzymatic activity is not understood. For example, all strains of the human bacterial pathogen group A Streptococcus (GAS) produce at least one extracellular DNase, and most strains make several distinct enzymes. Despite six decades of study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumby P,Barbian KD,Gardner DJ,Whitney AR,Welty DM,Long RD,Bailey JR,Parnell MJ,Hoe NP,Adams GG,Deleo FR,Musser JM

更新日期：2005-02-01 00:00:00

abstract：:Animals treated with potent gamma-glutamyl transpeptidase inhibitors and a patient with severe gamma-glutamyl transpeptidase deficiency excrete much larger than normal amounts of glutathione, gamma-glutamylcysteine, and cysteine in their urine; these compounds were found in disulfide forms. The findings indicate that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith OW,Meister A

更新日期：1980-06-01 00:00:00