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Sequence physical properties encode the global organization of protein structure space.

Abstract：

:It is demonstrated that, properly represented, the amino acid composition of protein sequences contains the information necessary to delineate the global properties of protein structure space. A numerical representation of amino acid sequence in terms of a set of property factors is used, and the values of those property factors are averaged over individual sequences and then over sets of sequences belonging to structurally defined groups. These sequence sets then can be viewed as points in a 10-dimensional space, and the organization of that space, determined only by sequence properties, is similar at both local and global scales to that of the space of protein structures determined previously.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Rackovsky S

doi

10.1073/pnas.0903433106

subject

Has Abstract

pub_date

2009-08-25 00:00:00

pages

14345-8

issue

34

eissn

0027-8424

issn

1091-6490

pii

0903433106

journal_volume

106

pub_type

杂志文章

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