Structure and mechanism of mouse cysteine dioxygenase.

abstract：:Bordetella dermonecrotizing toxin causes assembly of actin stress fibers and focal adhesions in some cultured cells and induces mobility shifts of the small GTP-binding protein Rho on electrophoresis. We attempted to clarify the molecular basis of the toxin action on Rho. Analysis of the amino acid sequence of toxin-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horiguchi Y,Inoue N,Masuda M,Kashimoto T,Katahira J,Sugimoto N,Matsuda M

更新日期：1997-10-14 00:00:00

abstract：:The fah1 mutant of Arabidopsis is defective in the accumulation of sinapic acid-derived metabolites, including the guaiacyl-syringyl lignin typical of angiosperms. Earlier results indicated that the FAH1 locus encodes ferulate-5-hydroxylase (F5H), a cytochrome P450-dependent monooxygenase (P450) of the general phenylp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer K,Cusumano JC,Somerville C,Chapple CC

更新日期：1996-07-09 00:00:00

abstract：:Chronic stress is known to promote inflammatory bowel disease (IBD), but the underlying mechanism remains largely unresolved. Here, we found chronic stress to sensitize mice to dextran sulfate sodium (DSS)-induced colitis; to increase the infiltration of B cells, neutrophils, and proinflammatory ly6Chi macrophages in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Cao Q,Cheng Y,Zhao D,Wang Z,Yang H,Wu Q,You L,Wang Y,Lin Y,Li X,Wang Y,Bian JS,Sun D,Kong L,Birnbaumer L,Yang Y

更新日期：2018-03-27 00:00:00

abstract：:To study C(0)a priori estimates for solutions to certain complex Monge-Ampère equations, I introduce a coherent sheaf of ideals and show that it satisfies various global algebrogeometric conditions, including a cohomology vanishing theorem. This technique is used to establish the existence of Kähler-Einstein metrics o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadel AM

更新日期：1989-10-01 00:00:00

abstract：:Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These proinflammatory regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji Z,He L,Regev A,Struhl K

更新日期：2019-05-07 00:00:00

abstract：:The epothilones represent a promising class of natural product-based antitumor drug candidates. Although these compounds operate through a microtubule stabilization mechanism similar to that of taxol, the epothilones offer a major potential therapeutic advantage in that they retain their activity against multidrug-res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,Zhang X,Zhong ZY,Li Y,Feng L,Eng S,Myles DR,Johnson R Jr,Wu N,Yin YI,Wilson RM,Danishefsky SJ

更新日期：2008-09-02 00:00:00

abstract：:ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases whose human mutations result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system phenotypes. Both proteins are nuclear-localized in keeping with their DDR functions, yet both are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng A,Zhao T,Tse KH,Chow HM,Cui Y,Jiang L,Du S,Loy MMT,Herrup K

更新日期：2018-01-09 00:00:00

abstract：:Wine chemical compositions, which result from a complex interplay between environmental factors, genetic factors, and viticultural practices, have mostly been studied using targeted analyses of selected families of metabolites. Detailed studies have particularly concerned volatile and polyphenolic compounds because of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gougeon RD,Lucio M,Frommberger M,Peyron D,Chassagne D,Alexandre H,Feuillat F,Voilley A,Cayot P,Gebefügi I,Hertkorn N,Schmitt-Kopplin P

更新日期：2009-06-09 00:00:00

abstract：:Intermolecular electronic coupling dictates the optical properties of molecular aggregate systems. Of particular interest are photosynthetic pigment-protein complexes that absorb sunlight then efficiently direct energy toward the photosynthetic reaction center. Two-dimensional (2D) ultrafast spectroscopy has been used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read EL,Engel GS,Calhoun TR,Mancal T,Ahn TK,Blankenship RE,Fleming GR

更新日期：2007-09-04 00:00:00

abstract：:The 2-deoxy-D-glucose method was used to study asymmetries in cerebral metabolic activity in neonatal rats. Left-right asymmetries in 2-deoxy-D-glucose uptake were observed in hippocampus, diencephalon, cortex, and medulla-pons: 2-deoxy-D-glucose incorporation was greater in right hippocampus, right diencephalon, left...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross DA,Glick SD,Meibach RC

更新日期：1981-03-01 00:00:00

abstract：:Aerobic respiration is a fundamental energy-generating process; however, there is cost associated with living in an oxygen-rich environment, because partially reduced oxygen species can damage cellular components. Organisms evolved enzymes that alleviate this damage and protect the intracellular milieu, most notably t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaya A,Gerashchenko MV,Seim I,Labarre J,Toledano MB,Gladyshev VN

更新日期：2015-08-25 00:00:00

abstract：:X-ray grating interferometry is a coherent imaging technique that bears tremendous potential for three-dimensional tomographic imaging of soft biological tissue and other specimens whose details exhibit very weak absorption contrast. It is intrinsically trimodal, delivering phase contrast, absorption contrast, and sca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanette I,Bech M,Rack A,Le Duc G,Tafforeau P,David C,Mohr J,Pfeiffer F,Weitkamp T

更新日期：2012-06-26 00:00:00

abstract：:What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirase H,Leinekugel X,Czurkó A,Csicsvari J,Buzsáki G

更新日期：2001-07-31 00:00:00

abstract：:Gaseous molecular ions containing argon and perchlorethylene, Ar(n)(C(2)Cl(4))(m) (+) in which n >/= 1-29 and m >/= 1-4, are produced by electron bombardment of van der Waals clusters formed by expanding an Ar/C(2)Cl(4) mixture through a supersonic nozzle. Previous attempts to observe such ions in a high-pressure mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buelow SJ,Worsnop DR,Herschbach DR

更新日期：1981-12-01 00:00:00

abstract：:The mitotic (or spindle assembly) checkpoint system prevents premature separation of sister chromatids in mitosis. When the checkpoint is turned on, the mitotic checkpoint complex (MCC) inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). MCC is composed of the checkpoint proteins BubR1, Bub3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Sitry-Shevah D,Teichner A,Hershko A

更新日期：2013-06-25 00:00:00

abstract：:The adenoviral E1A oncogene sensitizes mammalian cells to tumor necrosis factor-alpha (TNF-alpha), in part by repressing the nuclear factor-kappa B (NF-kappa B)-dependent defense against this cytokine. Other E1A activities involve binding to either p300/cyclic AMP response element-binding protein (CBP) or retinoblasto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JL,Walker TA,Worthen GS,Radke JR

更新日期：2002-07-23 00:00:00

abstract：:The CD4 receptor contributes to T-cell activation by coligating major histocompatibility complex class II on antigen presenting cells with the T-cell receptor (TCR)/CD3 complex, and triggering a cascade of signaling events including tyrosine phosphorylation of intracellular proteins. Paradoxically, CD3 cross-linking p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desbarats J,Freed JH,Campbell PA,Newell MK

更新日期：1996-10-01 00:00:00

abstract：:Most current gene transfer methods function satisfactorily in specialized systems involving established cell lines but are often not applicable with nonadherent, primary hematopoietic cells, which are notoriously difficult to transfect. To approach this problem, we have investigated an alternative method of gene trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zenke M,Steinlein P,Wagner E,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:The rates of reassociation of DNA from a monkey cell line (Vero), from SV40 pseudovirus (consisting of Vero DNA and virus protein coat), and from mature SV40 were measured. The results show that the host DNA in the pseudovirus contains repeated and unique sequences in the same proportions as normal host DNA; hence, no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grady L,Axelrod D,Trilling D

更新日期：1970-12-01 00:00:00

abstract：:Understanding the genetic networks that operate inside cells will require the dissection of interactions among network members. Here we describe a peptide aptamer isolated from a combinatorial library that distinguishes among such interactions. This aptamer binds to cyclin-dependent kinase 2 (Cdk2) and inhibits its ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen BA,Colas P,Brent R

更新日期：1998-11-24 00:00:00

abstract：:The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic anion-binding protein] have been isolated from the basolateral plasma-membrane domain of the hepatocyte. To investigate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres AM,Lunazzi GC,Stremmel W,Tiribelli C

更新日期：1993-09-01 00:00:00

abstract：:The transporter associated with antigen processing (TAP) is essential for intracellular transport of protein fragments into the endoplasmic reticulum for loading of major histocompatibility complex (MHC) class I molecules. On the cell surface, these peptide-MHC complexes are monitored by cytotoxic T lymphocytes. To st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorbulev S,Abele R,Tampé R

更新日期：2001-03-27 00:00:00

abstract：:The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of the unphotolyzed E181Q mutant are nearly identical to spectra of the native pigment, supporting the view that Glu-181 is uncharged...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan EC,Kazmi MA,Ganim Z,Hou JM,Pan D,Chang BS,Sakmar TP,Mathies RA

更新日期：2003-08-05 00:00:00

abstract：:We predict by first principles a phase transition in alumina at approximately 3.7 Mbar and room temperature from the CaIrO(3)-type polymorph to another with the U(2)S(3)-type structure. Because alumina is used as window material in shock-wave experiments, this transformation should be important for the analysis of sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umemoto K,Wentzcovitch RM

更新日期：2008-05-06 00:00:00

abstract：:Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht LV,Ploper D,Tejeda-Muñoz N,De Robertis EM

更新日期：2018-06-05 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:Copper is an essential metal nutrient that is tightly regulated in the body because loss of its homeostasis is connected to severe diseases such as Menkes and Wilson diseases, Alzheimer's disease, prion disorders, and amyotrophic lateral sclerosis. The complex relationships between copper status and various stages of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirayama T,Van de Bittner GC,Gray LW,Lutsenko S,Chang CJ

更新日期：2012-02-14 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:Cyclotides are plant defense peptides that have been extensively investigated for pharmaceutical and agricultural applications, but key details of their posttranslational biosynthesis have remained elusive. Asparaginyl endopeptidases are crucial in the final stage of the head-to-tail cyclization reaction, but the enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm FBH,Jackson MA,De Geyter E,Yap K,Gilding EK,Durek T,Craik DJ

更新日期：2019-04-16 00:00:00

abstract：:Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach--Repli Seq--to map temporally ordered replicating DNA using massively parallel sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen RS,Thomas S,Sandstrom R,Canfield TK,Thurman RE,Weaver M,Dorschner MO,Gartler SM,Stamatoyannopoulos JA

更新日期：2010-01-05 00:00:00