Abstract:
:The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through the induction/activation of regulatory T cells (Tr). The possibility to generate tolerogenic DCs opens new therapeutic perspectives in autoimmune/inflammatory diseases. Therefore, the characterization of the endogenous factors that contribute to the development of tolerogenic DCs is highly relevant. In this study, we report on the use of the known immunosuppressive neuropeptide, the vasoactive intestinal peptide, as a new approach to induce tolerogenic DCs with capacity to generate Tr cells, to restore tolerance in vivo, and to reduce the progression of rheumatoid arthritis and experimental autoimmune encephalomyelitis.
journal_name
Proc Natl Acad Sci U S Aauthors
Chorny A,Gonzalez-Rey E,Fernandez-Martin A,Pozo D,Ganea D,Delgado Mdoi
10.1073/pnas.0504484102keywords:
subject
Has Abstractpub_date
2005-09-20 00:00:00pages
13562-7issue
38eissn
0027-8424issn
1091-6490pii
0504484102journal_volume
102pub_type
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