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A human transporter protein that mediates the final excretion step for toxic organic cations.

Abstract：

:In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood. Here, we show that MATE1, a human and mouse orthologue of the multidrug and toxin extrusion family conferring multidrug resistance on bacteria, is primarily expressed in the kidney and liver, where it is localized to the luminal membranes of the urinary tubules and bile canaliculi. When expressed in HEK293 cells, MATE1 mediates H(+)-coupled electroneutral exchange of tetraethylammonium and 1-methyl-4-phenylpyridinium. Its substrate specificity is similar to those of renal and hepatic H(+)-coupled organic cations (OCs) export. Thus, MATE1 appears to be the long searched for polyspecific OC exporter that directly transports toxic OCs into urine and bile.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Otsuka M,Matsumoto T,Morimoto R,Arioka S,Omote H,Moriyama Y

doi

10.1073/pnas.0506483102

keywords:

subject

Has Abstract

pub_date

2005-12-13 00:00:00

pages

17923-8

issue

50

eissn

0027-8424

issn

1091-6490

pii

0506483102

journal_volume

102

pub_type

杂志文章

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