Dissociation of object and spatial visual processing pathways in human extrastriate cortex.

abstract：:The TFIID transcription initiation complex is composed of TBP and multiple TAFs. Studies in unicellular systems indicate that TAF250 is required for progression through G(1)/S of the cell cycle and repression of apoptosis. Here we extend these in vivo studies by determining the developmental requirements for TAF250 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wassarman DA,Aoyagi N,Pile LA,Schlag EM

更新日期：2000-02-01 00:00:00

abstract：:The cellular alterations associated with skeletal muscle differentiation share a high degree of similarity with key phenotypic changes usually ascribed to apoptosis. For example, actin fiber disassembly/reorganization is a conserved feature of both apoptosis and differentiating myoblasts and the conserved muscle contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernando P,Kelly JF,Balazsi K,Slack RS,Megeney LA

更新日期：2002-08-20 00:00:00

abstract：:The canonical function of the human telomerase protein (hTERT) is to synthesize telomeric DNA, but it has other biological activities, including enhancing cell proliferation, decreasing apoptosis, regulating DNA damage responses, and increasing cellular proliferative lifespan. The mechanistic relationships among these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee S,Firpo EJ,Wang Y,Roberts JM

更新日期：2011-12-13 00:00:00

abstract：:Ancient DNA (aDNA) analysis provides a powerful means of investigating human migration, social organization, and a plethora of other crucial questions about humanity's past. Recently, specialists have suggested that the ideal research design involving aDNA would include multiple independent lines of evidence. In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongers JL,Nakatsuka N,O'Shea C,Harper TK,Tantaleán H,Stanish C,Fehren-Schmitz L

更新日期：2020-08-04 00:00:00

abstract：:In the developing CNS, Notch1 and its ligand, Jagged1, regulate oligodendrocyte differentiation and myelin formation, but their role in repair of demyelinating lesions in diseases such as multiple sclerosis remains unresolved. To address this question, we generated a mouse model in which we targeted Notch1 inactivatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Argaw AT,Gurfein BT,Zameer A,Snyder BJ,Ge C,Lu QR,Rowitch DH,Raine CS,Brosnan CF,John GR

更新日期：2009-11-10 00:00:00

abstract：:The expression of at least 24 distinct genes of Pseudomonas aeruginosa PAO1 is under direct control of the "ferric uptake regulator" (Fur). Novel targets of the Fur protein were isolated in a powerful SELEX (systematic evolution of ligands by exponential enrichment)-like cycle selection consisting of in vitro DNA-Fur ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochsner UA,Vasil ML

更新日期：1996-04-30 00:00:00

abstract：:Earlier we have shown that oscillations with a long period ("supercycles") may arise in two-locus systems experiencing cyclical selection with a short period. However, this mode of complex limiting behavior appeared to be possible for narrow ranges of parameters. Here we demonstrate that a multilocus system subjected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirzhner VM,Korol AB,Nevo E

更新日期：1996-06-25 00:00:00

abstract：:In RBL-2H3 rat tumor mast cells, cross-linking the high-affinity IgE receptor Fc epsilon RI causes tyrosine phosphorylation of multiple proteins. These phosphoproteins include phospholipase C gamma 1, the beta and gamma subunits of the Fc epsilon RI, the Src family protein-tyrosine kinase Lyn, and a 72-kDa protein tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutchcroft JE,Geahlen RL,Deanin GG,Oliver JM

更新日期：1992-10-01 00:00:00

abstract：:We present a method for designing a funnel-shaped free-energy surface that reproducibly assembles secondary structure elements of proteins into their native conformations from a random extended configuration. Assuming a priori knowledge of secondary structure, our method can design a funnel-shaped surface for folding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fain B,Levitt M

更新日期：2003-09-16 00:00:00

abstract：:Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional role of CA activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkkila S,Rajaniemi H,Parkkila AK,Kivela J,Waheed A,Pastorekova S,Pastorek J,Sly WS

更新日期：2000-02-29 00:00:00

abstract：:Near-zero-index (NZI) supercoupling, the transmission of electromagnetic waves inside a waveguide irrespective of its shape, is a counterintuitive wave effect that finds applications in optical interconnects and engineering light-matter interactions. However, there is a limited knowledge on the local properties of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liberal I,Lobet M,Li Y,Engheta N

更新日期：2020-09-29 00:00:00

abstract：:The free and membrane-bound ribosomes of hepatic cells were isolated and used to program protein synthesis in cell-free extracts. Immuno-electrophoretic and radioautographic analysis of the products showed that the membrane-bound ribosomes synthesized serum proteins, whereas ribosomes free of endoplasmic reticulum syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ganoza MC,Williams CA

更新日期：1969-08-01 00:00:00

abstract：:Multiple-choice examinations play a critical role in university admissions across the world. A key question is whether imposing penalties for wrong answers on these examinations deters guessing from women more than men, disadvantaging female test-takers. We consider data from a large-scale, high-stakes policy change t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffman KB,Klinowski D

更新日期：2020-04-21 00:00:00

abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

更新日期：2004-07-20 00:00:00

abstract：:Cytochrome c peroxidase reacts with peroxide to form compound I, which contains an oxyferryl heme and an indolyl radical at Trp-191. The indolyl free radical has a half-life of several hours at room temperature, and this remarkable stability is essential for the catalytic function of cytochrome c peroxidase. To probe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MA,Han GW,Kraut J

更新日期：1994-11-08 00:00:00

abstract：:Restriction site variation in DNA that encodes rRNA (rDNA) was surveyed among 714 offspring within 31 lineages (26 genotypes) of obligate asexually reproducing Taraxacum officinale (dandelions). Although clonal offspring are expected, plants with nonparental rDNA were produced from two parents that were themselves sib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： King LM,Schaal BA

更新日期：1990-02-01 00:00:00

abstract：:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the nc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles BA,Hawley RS

更新日期：1991-08-15 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:The enzyme p-cresol methylhydroxylase [4-cresol: (acceptor) oxidoreductase (methyl-hydroxylating), EC 1.17.99.1] contains two subunits: a cytochrome c (electron transfer) subunit (cytochrome cpc) and a flavin (catalytic) subunit. When these subunits are separated by isoelectric focusing, a stable cytochrome subunit is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLendon GL,Bagby S,Charman JA,Driscoll PC,McIntire WS,Mathews FS,Hill HA

更新日期：1991-11-01 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:Antigen-specific activation of T lymphocytes, via stimulation of the T-cell antigen receptor (TCR) complex, is marked by a rapid and sustained increase in the concentration of cytoplasmic free Ca2+ ([Ca2+]i). It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman T,Ondriasová E,Ondrias K,Harnick DJ,Marks AR

更新日期：1995-06-20 00:00:00

abstract：:BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JP,Klitzman JM,Hellström I,Nowinski RC,Hellström KE

更新日期：1978-02-01 00:00:00

abstract：:alpha-Isopropylmalate synthase [3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methylbutyrate-lyase (CoA-acetylating); EC 4.1.3.12], the enzyme catalyzing the first committed step in leucine biosynthesis, and homocitrate synthase [3-hydroxy-3-carboxyadipate 2-oxoglutarate-lyase (CoA-acetylating); EC 4.1.3.21], the first...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tracy JW,Kohlhaw GB

更新日期：1975-05-01 00:00:00

abstract：:Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) is inevitable in metastatic EGFR-mutant lung cancers. Here, we modeled disease progression using EGFR-mutant human tumor cell lines. Although five of six models displayed alterations already found in humans, one harbored an unexpected seconda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohashi K,Sequist LV,Arcila ME,Moran T,Chmielecki J,Lin YL,Pan Y,Wang L,de Stanchina E,Shien K,Aoe K,Toyooka S,Kiura K,Fernandez-Cuesta L,Fidias P,Yang JC,Miller VA,Riely GJ,Kris MG,Engelman JA,Vnencak-Jones CL,D

更新日期：2012-07-31 00:00:00

abstract：:Two-dimensional gel electrophoresis of immunoprecipitated human HLA-DR antigens from cells expressing the HLA-DR4 haplotype shows distinct clustering of beta-chain patterns. Six unique electrophoretic variants were observed among 17 HLA-DR4 homozygous cell lines (HCL) analyzed. These patterns correlate precisely with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepom BS,Nepom GT,Mickelson E,Antonelli P,Hansen JA

更新日期：1983-11-01 00:00:00

abstract：:The members of the chimaerin family of Rac-GTPase-activating proteins possess a single C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This domain in PKCs is involved in phorbol ester and diacylglycerol (DAG) binding. We previously have demonstrated that one of the chimaerin isoforms,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caloca MJ,Garcia-Bermejo ML,Blumberg PM,Lewin NE,Kremmer E,Mischak H,Wang S,Nacro K,Bienfait B,Marquez VE,Kazanietz MG

更新日期：1999-10-12 00:00:00

abstract：:Transforming growth factor beta (TGF-beta)-mediated G(1) arrest previously has been shown to specifically target inactivation of cyclin D:cyclin-dependent kinase (Cdk) 4/6 complexes. We report here that TGF-beta-treated human HepG2 hepatocellular carcinoma cells arrest in G(1), but retain continued cyclin D:Cdk4/6 act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagahara H,Ezhevsky SA,Vocero-Akbani AM,Kaldis P,Solomon MJ,Dowdy SF

更新日期：1999-12-21 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:Mixed-metal oxides play a very important role in many areas of chemistry, physics, materials science, and geochemistry. Recently, there has been a strong interest in understanding phenomena associated with the deposition of oxide nanoparticles on the surface of a second (host) oxide. Here, scanning tunneling microscop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JB,Graciani J,Evans J,Stacchiola D,Ma S,Liu P,Nambu A,Sanz JF,Hrbek J,Rodriguez JA

更新日期：2009-03-31 00:00:00

abstract：:The transforming growth factors beta (TGF-beta s) are important modulators of growth and differentiation. They are intermolecular disulfide-bonded homodimeric molecules. The monomer fold has a conserved cystine knot and lacks a hydrophobic core. The biological specificity of a given member of the family is believed to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venkataraman G,Sasisekharan V,Cooney CL,Langer R,Sasisekharan R

更新日期：1995-06-06 00:00:00