Abstract:
:We present a method for designing a funnel-shaped free-energy surface that reproducibly assembles secondary structure elements of proteins into their native conformations from a random extended configuration. Assuming a priori knowledge of secondary structure, our method can design a funnel-shaped surface for folding of alpha, beta, and alphabeta structures individually. We design energy surfaces that fold up to five unrelated sequences with the same energy parameters. We develop a measure of the foldability of an energy landscape in silico and present an alternative way to view energy landscapes.
journal_name
Proc Natl Acad Sci U S Aauthors
Fain B,Levitt Mdoi
10.1073/pnas.1732312100keywords:
subject
Has Abstractpub_date
2003-09-16 00:00:00pages
10700-5issue
19eissn
0027-8424issn
1091-6490pii
1732312100journal_volume
100pub_type
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