Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.

abstract：:Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety, in vivo persistence, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yee C,Thompson JA,Byrd D,Riddell SR,Roche P,Celis E,Greenberg PD

更新日期：2002-12-10 00:00:00

abstract：:Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The "planetary boundaries" concept [Rockström J, et al. (2009) Nature 461(7263):472-475], and its extension through the addition of social well-being indicators t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole MJ,Bailey RM,New MG

更新日期：2014-10-21 00:00:00

abstract：:Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-lu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan CT,Reeves RE,Geller R,Yaghoubi SS,Hoehne A,Solow-Cordero DE,Chiosis G,Massoud TF,Paulmurugan R,Gambhir SS

更新日期：2012-09-11 00:00:00

abstract：:Wnt signaling is required for the maintenance of intestinal stem cells and self-renewal of the intestinal epithelium. Intestinal cancers are frequently associated with mutations that activate the Wnt pathway. The role of Wnt signaling on differentiation of lineage-specific precursors in the intestine is not well chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Giel-Moloney M,Rindi G,Leiter AB

更新日期：2007-07-03 00:00:00

abstract：:Fish have somehow colonized isolated water bodies all over the world without human assistance. It has long been speculated that these colonization events are assisted by waterbirds, transporting fish eggs attached to their feet and feathers, yet empirical support for this is lacking. Recently, it was suggested that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovas-Kiss Á,Vincze O,Löki V,Pallér-Kapusi F,Halasi-Kovács B,Kovács G,Green AJ,Lukács BA

更新日期：2020-07-07 00:00:00

abstract：:Polyketides represent an extremely diverse class of secondary metabolites often explored for their bioactive traits. These molecules are also attractive building blocks for chemical catalysis and polymerization. However, the use of polyketides in larger scale chemistry applications is stymied by limited titers and yie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markham KA,Palmer CM,Chwatko M,Wagner JM,Murray C,Vazquez S,Swaminathan A,Chakravarty I,Lynd NA,Alper HS

更新日期：2018-02-27 00:00:00

abstract：:A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from a human skeletal muscle cDNA library. The cDNA encodes a protein of 1174 amino acids with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family, which also includes the tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Møller NP,Møller KB,Lammers R,Kharitonenkov A,Sures I,Ullrich A

更新日期：1994-08-02 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:In an earlier paper, the author jointly with S. Suryawanshi proposed statistical analysis of shape through triangulation of landmarks on objects. It was observed that the angles of the triangles are invariant to scaling, location, and rotation of objects. No distinction was made between an object and its reflection. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao CR

更新日期：2000-03-28 00:00:00

abstract：:The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal cord via the pontine micturition center (PMC). Here, we exploit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyun M,Taranda J,Radeljic G,Miner L,Wang W,Ochandarena N,Huang KW,Osten P,Sabatini BL

更新日期：2021-01-05 00:00:00

abstract：:Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Zhu LL,Lu P,Yuen T,Li J,Ma R,Baliram R,Moonga SS,Liu P,Zallone A,New MI,Davies TF,Zaidi M

更新日期：2013-06-11 00:00:00

abstract：:Recent research has emphasized the importance of the metabolic cluster, which includes glucose intolerance, dyslipidemia, and high blood pressure, as a strong predictor of the obesity-related morbidities and premature mortality. Fundamental to this association, commonly referred to as the metabolic syndrome, is the cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kissebah AH,Sonnenberg GE,Myklebust J,Goldstein M,Broman K,James RG,Marks JA,Krakower GR,Jacob HJ,Weber J,Martin L,Blangero J,Comuzzie AG

更新日期：2000-12-19 00:00:00

abstract：:Fragile X syndrome, the most frequent form of hereditary mental retardation, is due to a mutation of the fragile X mental retardation 1 (FMR1) gene on the X chromosome. Like fragile X patients, FMR1-knockout (FMR1-KO) mice lack the normal fragile X mental retardation protein (FMRP) and show both cognitive alterations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Restivo L,Ferrari F,Passino E,Sgobio C,Bock J,Oostra BA,Bagni C,Ammassari-Teule M

更新日期：2005-08-09 00:00:00

abstract：:In the mitochondrial genome of the hemichordate Balanoglossus carnosus, the codon AAA, which is assigned to lysine in most metazoans but to asparagine in echinoderms, is absent. Furthermore, the lysine tRNA gene carries an anticodon substitution that renders its gene product unable to decode AAA codons, whereas the as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castresana J,Feldmaier-Fuchs G,Pääbo S

更新日期：1998-03-31 00:00:00

abstract：:The L-A double-stranded RNA virus of Saccharomyces cerevisiae makes a gag-pol fusion protein by a -1 ribosomal frameshift. The pol amino acid sequence includes consensus patterns typical of the RNA-dependent RNA polymerases (EC 2.7.7.48) of (+) strand and double-stranded RNA viruses of animals and plants. We have carr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribas JC,Wickner RB

更新日期：1992-03-15 00:00:00

abstract：:Mitochondrial dysfunctions cause numerous human disorders. A platform technology based on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix could be of enormous potential benefit in treating mitochondrial diseases. Here we report a rationally designed mitochondria-targeted polymeric n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Dhar S

更新日期：2012-10-02 00:00:00

abstract：:Heterogeneous nucleation is vital to a wide range of areas as diverse as ice nucleation on atmospheric aerosols and the fabrication of high-performance thin films. There is excellent evidence that surface topography is a key factor in directing crystallization in real systems; however, the mechanisms by which nanoscal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell JM,Meldrum FC,Christenson HK

更新日期：2017-01-31 00:00:00

abstract：:A MODEL OF THE LINEAR HYDROGEN BOND HAS BEEN DEVISED WHICH IS CHARACTERIZED BY THREE PHYSICAL PARAMETERS OF THE ISOLATED ELECTRON DONOR AND PROTON DONOR MOLECULES: mu(A-H), the bond dipole moment; DeltaI, the difference in ionization potential between that of the electron donor and the corresponding noble gas atom; an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allen LC

更新日期：1975-12-01 00:00:00

abstract：:In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pando B,Dawson SP,Mak DO,Pearson JE

更新日期：2006-04-04 00:00:00

abstract：:We measured quantitatively the binding affinities of purified Cro repressor to the chemically synthesized wild-type and mutant OR1 operators, consisting of all three possible base-pair substitutions and of thymine to uracil substitutions at each base-pair position of the 17-base-pair operator sequence. The sequence-sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda Y,Sarai A,Rivera VM

更新日期：1989-01-01 00:00:00

abstract：:Bacteria commonly grow in densely populated surface-bound communities, termed biofilms, where they gain benefits including superior access to nutrients and resistance to environmental insults. The secretion of extracellular polymeric substances (EPS), which bind bacterial collectives together, is ubiquitously associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadell CD,Bassler BL

更新日期：2011-08-23 00:00:00

abstract：:Various reconstructive procedures have been attempted to restore a cosmetically acceptable phallus that would allow normal reproductive, sexual, and urinary function in patients requiring penile reconstruction. However, these procedures are limited by a shortage of native penile tissue. We previously demonstrated that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen KL,Eberli D,Yoo JJ,Atala A

更新日期：2010-02-23 00:00:00

abstract：:When propagated on arl strains (a subclass of Escherichia coli hyper-rec mutants), lambda "Red-" duplication phages accumulated an enhanced potential for recombination. The physical properties of the recombinogenic phages thus obtained ("Arl-" phages) were similar to those of phages grown on arl+ bacteria. However, Ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hays JB,Korba BE

更新日期：1979-12-01 00:00:00

abstract：:Different strains of Newcastle disease virus vary in their ability to induce cell fusion. When administered to cells at high multiplicities of infection some strains induce cell fusion within three hours. This type of fusion is apparently caused by the virus particles in the inoculum, since it can be induced by noninf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bratt MA,Gallaher WR

更新日期：1969-10-01 00:00:00

abstract：:In our 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY experiment, the TROSY principle (transverse relaxation-optimized spectroscopy) is used in three-dimensional (3D) (15)N-resolved nuclear Overhauser enhancement spectroscopy (NOESY), which enables resonance assignments by sequential nuclear Overhauser effects and the collection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pervushin KV,Wider G,Riek R,Wüthrich K

更新日期：1999-08-17 00:00:00

abstract：:In this paper, we describe the structure of chitinase B from Serratia marcescens, which consists of a catalytic domain with a TIM-barrel fold and a 49-residue C-terminal chitin-binding domain. This chitinase is the first structure of a bacterial exochitinase, and it represents one of only a few examples of a glycosyl ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Aalten DM,Synstad B,Brurberg MB,Hough E,Riise BW,Eijsink VG,Wierenga RK

更新日期：2000-05-23 00:00:00

abstract：:Most B lymphocytes in normal individuals express two classes of cell-surface immunoglobulins, IgM and IgD. The specificity of the two antigen receptors is identical since they are produced by transcription and differential splicing of the same variable region gene segment to the heavy-chain constant region gene segmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irsch J,Irlenbusch S,Radl J,Burrows PD,Cooper MD,Radbruch AH

更新日期：1994-02-15 00:00:00

abstract：:Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin the well established association between smoking and the increased risk of sudden infant death syndrome. We show here that the protective response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen G,Han ZY,Grailhe R,Gallego J,Gaultier C,Changeux JP,Lagercrantz H

更新日期：2002-10-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the master circadian clock in mammals, sends major output signals to the subparaventricular zone (SPZ) and further to the paraventricular nucleus (PVN), the neural mechanism of which is largely unknown. In this study, the intracellular calcium levels were measured continuously in cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YE,Enoki R,Oda Y,Huang ZL,Honma KI,Honma S

更新日期：2018-10-02 00:00:00

abstract：:Mixed synthetic oligonucleotides encoding sequences conserved among tyrosine-specific protein kinases were used to probe the genome of the budding yeast Saccharomyces cerevisiae. Two genes with homology to protein kinases were isolated and characterized by DNA sequence analysis. These genes, designated KIN1 and KIN2, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin DE,Hammond CI,Ralston RO,Bishop JM

更新日期：1987-09-01 00:00:00