Abstract:
:A pluripotent cell line, C3H10T1/2, is induced to undergo adipogenesis by a mixture of factors that includes a glucocorticoid such as dexamethasone. We found that expression of myostatin (MSTN), a TGF-beta family member extensively studied in muscle, was induced by dexamethasone under those differentiation conditions. Moreover, MSTN could substitute for dexamethasone in the adipogenesis mixture. However, the adipocytes induced by MSTN in both cell culture and transgenic mice were small and expressed markers characteristic of immature adipocytes. These adipocytes exhibited cell-autonomous increases in insulin sensitivity and glucose oxidation. In mice, these effects produced elevated systemic insulin sensitivity and resistance to diet-induced obesity. Modulation of the final stages of adipogenesis may provide a novel approach to understanding and treating metabolic disease.
journal_name
Proc Natl Acad Sci U S Aauthors
Feldman BJ,Streeper RS,Farese RV Jr,Yamamoto KRdoi
10.1073/pnas.0607501103subject
Has Abstractpub_date
2006-10-17 00:00:00pages
15675-80issue
42eissn
0027-8424issn
1091-6490pii
0607501103journal_volume
103pub_type
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