Abstract:
:Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS pincer ligand framework bound to nickel. The model complex mediates the dehydrogenation of alcohols, a reaction relevant to lactate racemization. Experimental and computational data indicate ligand participation in the dehydrogenation reaction.
journal_name
Proc Natl Acad Sci U S Aauthors
Xu T,Wodrich MD,Scopelliti R,Corminboeuf C,Hu Xdoi
10.1073/pnas.1616038114subject
Has Abstractpub_date
2017-02-07 00:00:00pages
1242-1245issue
6eissn
0027-8424issn
1091-6490pii
1616038114journal_volume
114pub_type
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