An Early Pleistocene hominin mandible from Atapuerca-TD6, Spain.

abstract：:T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory signal IL-4 and depends only on T cell receptor stimulation. Here, we show that in the course of Th2 cell differentiation in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Löhning M,Richter A,Stamm T,Hu-Li J,Assenmacher M,Paul WE,Radbruch A

更新日期：2003-10-14 00:00:00

abstract：:Accurate protein folding is essential for proper cellular and organismal function. In the cell, protein folding is carefully regulated; changes in folding homeostasis (proteostasis) can disrupt many cellular processes and have been implicated in various neurodegenerative diseases and other pathologies. For many protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samelson AJ,Jensen MK,Soto RA,Cate JH,Marqusee S

更新日期：2016-11-22 00:00:00

abstract：:Climate change is increasing fire activity in the western United States, which has the potential to accelerate climate-induced shifts in vegetation communities. Wildfire can catalyze vegetation change by killing adult trees that could otherwise persist in climate conditions no longer suitable for seedling establishmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis KT,Dobrowski SZ,Higuera PE,Holden ZA,Veblen TT,Rother MT,Parks SA,Sala A,Maneta MP

更新日期：2019-03-26 00:00:00

abstract：:Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm copurify with intermediate filaments from trophectoderm and a trophoblastoma cell line. A monoclonal antibody prepared ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brûlet P,Babinet C,Kemler R,Jacob F

更新日期：1980-07-01 00:00:00

abstract：:Many insects are dependent on bacterial symbionts that provide essential nutrients (ex. aphid-Buchnera and tsetse-Wiglesworthia associations), wherein the symbionts are harbored in specific cells called bacteriocytes that constitute a symbiotic organ bacteriome. Facultative and parasitic bacterial symbionts like Wolba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosokawa T,Koga R,Kikuchi Y,Meng XY,Fukatsu T

更新日期：2010-01-12 00:00:00

abstract：:Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition phenomena. It has previously been shown that small differences in the homophilic and heterophilic binding affinities of different type I family members can account ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vendome J,Felsovalyi K,Song H,Yang Z,Jin X,Brasch J,Harrison OJ,Ahlsen G,Bahna F,Kaczynska A,Katsamba PS,Edmond D,Hubbell WL,Shapiro L,Honig B

更新日期：2014-10-07 00:00:00

abstract：:Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westfall PJ,Pitera DJ,Lenihan JR,Eng D,Woolard FX,Regentin R,Horning T,Tsuruta H,Melis DJ,Owens A,Fickes S,Diola D,Benjamin KR,Keasling JD,Leavell MD,McPhee DJ,Renninger NS,Newman JD,Paddon CJ

更新日期：2012-01-17 00:00:00

abstract：:Nucleosomes are the fundamental structural unit of chromatin. In addition to stabilizing the DNA polymer, nucleosomes are modified in ways that reflect and affect gene expression in their vicinity. It has long been assumed that nucleosomes can transmit memory of gene expression through their covalent posttranslational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlissel G,Rine J

更新日期：2019-10-08 00:00:00

abstract：:Continuous intravenous infusion of heparin suppresses smooth muscle cell proliferation in rats after endothelial injury but may lead to hemorrhage and other complications. The anticoagulant property has been removed from chemically modified heparin without loss of antiproliferative effect but use of such compounds is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman ER,Adams DH,Karnovsky MJ

更新日期：1990-05-01 00:00:00

abstract：:High-throughput biological data, whether generated as sequencing, transcriptional microarrays, proteomic, or other means, continues to require analytic methods that address its high dimensional aspects. Because the computational part of data analysis ultimately identifies shape characteristics in the organization of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolau M,Levine AJ,Carlsson G

更新日期：2011-04-26 00:00:00

abstract：:The catalytic generation of chiral ester enolate equivalents from α,β-unsaturated aldehydes with chiral N-hetereocyclic carbene catalysts makes possible highly enantioselective hetero-Diels-Alder reactions. The reactions proceed under simple, mild conditions with both aliphatic and aromatic substituted enals as substr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaeobamrung J,Kozlowski MC,Bode JW

更新日期：2010-11-30 00:00:00

abstract：:Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties make bacteriophytochromes particularly attractive for optogenetic applications. However, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu MH,Kang IH,Nelson MD,Jensen TM,Lyuksyutova AI,Siltberg-Liberles J,Raizen DM,Gomelsky M

更新日期：2014-07-15 00:00:00

abstract：:The TCR is an alpha beta heterodimer, a part of the multimeric structure through which physiological T-cell activation occurs. The expression of TCR alpha chain is greatly diminished in a beta-chain-deficient mutant Jurkat cell line (J.RT3-T3.5). The relationship between the expression of the TCR alpha and beta chains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung S,Strominger JL

更新日期：1995-04-25 00:00:00

abstract：:Cucumber mosaic virus (CMV) and tomato aspermy virus (TAV) belong to the Cucumovirus genus. They have a tripartite genome consisting of single-stranded RNAs, designated 1, 2, and 3. Previous studies have shown that viable pseudorecombinants could be created in vitro by reciprocal exchanges between CMV and TAV RNA 3, b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuta C,Ueda S,Suzuki M,Uyeda I

更新日期：1998-09-01 00:00:00

abstract：:The rpoS gene of Escherichia coli encodes a putative RNA polymerase sigma factor that is considered to be the central regulator of gene expression in stationary phase. The gene product (sigma 38) was overproduced using the cloned rpoS gene and purified to homogeneity. Reconstituted RNA polymerase holoenzyme (E sigma 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka K,Takayanagi Y,Fujita N,Ishihama A,Takahashi H

更新日期：1993-04-15 00:00:00

abstract：:Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai channels in the plasma membrane. This inside-out mechanism of Ca2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KM,Wijerathne T,Hur JH,Kang UJ,Kim IH,Kweon YC,Lee AR,Jeong SJ,Lee SK,Lee YY,Sim BW,Lee JH,Baig C,Kim SU,Chang KT,Lee KP,Park CY

更新日期：2018-05-15 00:00:00

abstract：:We report the synthesis of a probe that permits the visualization by electron microscopy of acidic organelles in intact cells. This probe, 3-(2,4-dinitroanilino)-3'-amino-N-methyldipropylamine (DAMP), is a basic congener of dinitrophenol that readily diffuses into intact cells. Its primary and tertiary amino groups (a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson RG,Falck JR,Goldstein JL,Brown MS

更新日期：1984-08-01 00:00:00

abstract：:We demonstrate remote detection of nuclear magnetic resonance (NMR) with a microchip sensor consisting of a microfluidic channel and a microfabricated vapor cell (the heart of an atomic magnetometer). Detection occurs at zero magnetic field, which allows operation of the magnetometer in the spin-exchange relaxation-fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledbetter MP,Savukov IM,Budker D,Shah V,Knappe S,Kitching J,Michalak DJ,Xu S,Pines A

更新日期：2008-02-19 00:00:00

abstract：:The default mode network (DMN) has been suggested to support a variety of self-referential functions in humans and has been fractionated into subsystems based on distinct responses to cognitive tasks and functional connectivity architecture. Such subsystems are thought to reflect functional hierarchy and segregation w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu LM,Liang X,Gu H,Brynildsen JK,Stark JA,Ash JA,Lin CP,Lu H,Rapp PR,Stein EA,Yang Y

更新日期：2016-08-02 00:00:00

abstract：:125I-Labeled L-fucose-albumin complex and rat preputial beta-glucuronidase are rapidly cleared from plasma after intravenous infusion. L-Fucose-albumin retards the plasma clearance of beta-glucuronidase whereas D-fucose-albumin is inactive. In vitro, 125I-labeled L-fucose-albumin is taken up into rat or rabbit alveola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shepherd VL,Lee YC,Schlesinger PH,Stahl PD

更新日期：1981-02-01 00:00:00

abstract：:Mutations in the thyroid hormone receptor α 1 gene (THRA) have recently been identified as a cause of intellectual deficit in humans. Patients present with structural abnormalities including microencephaly, reduced cerebellar volume and decreased axonal density. Here, we show that directed differentiation of THRA muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger TG,Moran CM,Frangini A,Visser WE,Schoenmakers E,Muntoni F,Clark CA,Gadian D,Chong WK,Kuczynski A,Dattani M,Lyons G,Efthymiadou A,Varga-Khadem F,Simons BD,Chatterjee K,Livesey FJ

更新日期：2019-11-05 00:00:00

abstract：:In our 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY experiment, the TROSY principle (transverse relaxation-optimized spectroscopy) is used in three-dimensional (3D) (15)N-resolved nuclear Overhauser enhancement spectroscopy (NOESY), which enables resonance assignments by sequential nuclear Overhauser effects and the collection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pervushin KV,Wider G,Riek R,Wüthrich K

更新日期：1999-08-17 00:00:00

abstract：:Two adjacent, divergently transcribed, developmentally regulated genes of the maize chloroplast chromosome have different superhelical density/transcriptional activation profiles when transcribed in vitro by the homologous DNA-dependent RNA polymerase. Promoter-specific transcription of the gene for the beta and epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stirdivant SM,Crossland LD,Bogorad L

更新日期：1985-08-01 00:00:00

abstract：:Reversible biological electron transfer usually occurs between redox couples at standard redox potentials ranging from +0.8 to -0.5 V. Dearomatizing benzoyl-CoA reductases (BCRs), key enzymes of the globally relevant microbial degradation of aromatic compounds at anoxic sites, catalyze a biological Birch reduction bey...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huwiler SG,Löffler C,Anselmann SEL,Stärk HJ,von Bergen M,Flechsler J,Rachel R,Boll M

更新日期：2019-02-05 00:00:00

abstract：:Phytochrome A (phyA) is the only plant photoreceptor that perceives far-red light and then mediates various responses to this signal. Phosphorylation and dephosphorylation of oat phyA have been extensively studied, and it was shown that phosphorylation of a serine residue in the hinge region of oat phyA could regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Yang L,Duan J,Cheng J,Shen Y,Wang X,Han R,Li H,Li Z,Wang L,Terzaghi W,Zhu D,Chen H,Deng XW,Li J

更新日期：2018-12-11 00:00:00

abstract：:Chronic wounds represent a substantial public health problem. The development of tools that would enable sophisticated scrutiny of clinical wound tissue material is highly desirable. This work presents evidence enabling rapid specific identification and laser capture of blood vessels from human tissue in a manner whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy S,Patel D,Khanna S,Gordillo GM,Biswas S,Friedman A,Sen CK

更新日期：2007-09-04 00:00:00

abstract：:Although gamma/delta T cells express numerous in vitro functions similar to alpha/beta T cells, little is known about their biological functioning in vivo. Furthermore, it is unclear whether alpha/beta T cells and gamma/delta T cells act independently or in a coordinated way. In the present study, gamma/delta T cells ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufmann SH,Blum C,Yamamoto S

更新日期：1993-10-15 00:00:00

abstract：:Societies are complex systems, which tend to polarize into subgroups of individuals with dramatically opposite perspectives. This phenomenon is reflected-and often amplified-in online social networks, where, however, humans are no longer the only players and coexist alongside with social bots-that is, software-control...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stella M,Ferrara E,De Domenico M

更新日期：2018-12-04 00:00:00

abstract：:Locomotion of the nematode Caenorhabditis elegans is a key observable used in investigations ranging from behavior to neuroscience to aging. However, while the natural environment of this model organism is 3D, quantitative investigations of its locomotion have been mostly limited to 2D motion. Here, we present a quant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilbao A,Patel AK,Rahman M,Vanapalli SA,Blawzdziewicz J

更新日期：2018-04-17 00:00:00

abstract：:Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

更新日期：2012-07-24 00:00:00