Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue.

abstract：:ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases whose human mutations result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system phenotypes. Both proteins are nuclear-localized in keeping with their DDR functions, yet both are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng A,Zhao T,Tse KH,Chow HM,Cui Y,Jiang L,Du S,Loy MMT,Herrup K

更新日期：2018-01-09 00:00:00

abstract：:Colonization of land by plants was a major transition on Earth, but the developmental and genetic innovations required for this transition remain unknown. Physiological studies and the fossil record strongly suggest that the ability of the first land plants to form symbiotic associations with beneficial fungi was one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaux PM,Radhakrishnan GV,Jayaraman D,Cheema J,Malbreil M,Volkening JD,Sekimoto H,Nishiyama T,Melkonian M,Pokorny L,Rothfels CJ,Sederoff HW,Stevenson DW,Surek B,Zhang Y,Sussman MR,Dunand C,Morris RJ,Roux C,Wong GK

更新日期：2015-10-27 00:00:00

abstract：:Dense granules of platelets contain a high content of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A). We have previously demonstrated an antithrombotic effect of this compound in a live rabbit model. In the present study we find that certain synthetic Ap4A analogues are superior to Ap4A in inhibiting ADP-induced aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamecnik PC,Kim B,Gao MJ,Taylor G,Blackburn GM

更新日期：1992-03-15 00:00:00

abstract：:Tactile-foraging ducks are specialist birds known for their touch-dependent feeding behavior. They use dabbling, straining, and filtering to find edible matter in murky water, relying on the sense of touch in their bill. Here, we present the molecular characterization of embryonic duck bill, which we show contains a h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider ER,Anderson EO,Mastrotto M,Matson JD,Schulz VP,Gallagher PG,LaMotte RH,Gracheva EO,Bagriantsev SN

更新日期：2017-12-05 00:00:00

abstract：:Social status motivates much of human behavior. However, status may have been a relatively weak target of selection for much of human evolution if ancestral foragers tended to be more egalitarian. We test the "egalitarianism hypothesis" that status has a significantly smaller effect on reproductive success (RS) in for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Rueden CR,Jaeggi AV

更新日期：2016-09-27 00:00:00

abstract：:The mechanisms that cause aging are not well understood. The oxidative stress hypothesis proposes that the changes associated with aging are a consequence of random oxidative damage to biomolecules. We hypothesized that oxidation of specific proteins is critical in controlling the rate of the aging process. Utilizing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan LJ,Levine RL,Sohal RS

更新日期：1997-10-14 00:00:00

abstract：:The strong consistency of least squares estimates in multiple regression models with independent errors is obtained under minimal assumptions on the design and weak moment conditions on the errors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai TL,Robbins H,Wei CZ

更新日期：1978-07-01 00:00:00

abstract：:Transmission electron microscopy studies have been used to argue that magnetite crystals in carbonate from Martian meteorite ALH84001 have a composition and morphology indistinguishable from that of magnetotactic bacteria. It has even been claimed from scanning electron microscopy imaging that some ALH84001 magnetite ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss BP,Kim SS,Kirschvink JL,Kopp RE,Sankaran M,Kobayashi A,Komeili A

更新日期：2004-06-01 00:00:00

abstract：:Allosteric regulation of oxygen delivery by RBCs may have significant effects on tumor growth. Indeed, angiogenesis, the formation of new blood vessels, is induced in growing tumors by low oxygen partial pressure. Hypoxia-inducible genes are switched on, among which are the VEGF gene and its receptors. Most important,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kieda C,Greferath R,Crola da Silva C,Fylaktakidou KC,Lehn JM,Nicolau C

更新日期：2006-10-17 00:00:00

abstract：:The surface distributions of three different membrane integral proteins, beta2-microglobulin (part of the histocompatibility antigen complex), aminopeptidase (alpha-aminoacyl-peptide hydrolase; EC 3.4.11.2), and the Na+,K+-ATPase (ATP phosphohydrolase; EC 3.6.1.3) on human fibroblasts grown in monolayer culture have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ash JF,Louvard D,Singer SJ

更新日期：1977-12-01 00:00:00

abstract：:Recombinational repair of double-stranded DNA gaps was investigated in Ustilago maydis. The experimental system was designed for analysis of repair of an autonomously replicating plasmid containing a cloned gene disabled by an internal deletion. It was discovered that crossing over rarely accompanied gap repair. The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferguson DO,Holloman WK

更新日期：1996-05-28 00:00:00

abstract：:In eukaryotes, transfer RNAs (tRNAs) are transcribed in the nucleus yet function in the cytoplasm; thus, tRNA movement within the cell was believed to be unidirectional--from the nucleus to the cytoplasm. It is now known that mature tRNAs also move in a retrograde direction from the cytoplasm to the nucleus via retrog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kramer EB,Hopper AK

更新日期：2013-12-24 00:00:00

abstract：:In aqueous solution, aldehydes, and to a lesser extent ketones, hydrate to form geminal diols. We investigate the hydration of methylglyoxal (MG) in the gas phase, a process not previously considered to occur in water-restricted environments. In this study, we spectroscopically identified methylglyoxal diol (MGD) and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axson JL,Takahashi K,De Haan DO,Vaida V

更新日期：2010-04-13 00:00:00

abstract：:Drosophila melanogaster Polo kinase physically interacts with, and is repressed by, the Matrimony (Mtrm) protein during oogenesis. Females heterozygous for a deletion of the mtrm gene display defects in chromosome segregation at meiosis I. However, a complete absence of Mtrm results in both meiotic catastrophe and fem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonner AM,Hughes SE,Chisholm JA,Smith SK,Slaughter BD,Unruh JR,Collins KA,Friederichs JM,Florens L,Swanson SK,Pelot MC,Miller DE,Washburn MP,Jaspersen SL,Hawley RS

更新日期：2013-03-26 00:00:00

abstract：:The involvement of gangliosides in processes related to nerve regeneration and sprouting has been demonstrated recently. The type of interaction by which gangliosides may influence neuronal sprouting was investigated in the present work. Affinity-purified rabbit anti-GM1 antibodies were found to block the sprouting fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz M,Spirman N

更新日期：1982-10-01 00:00:00

abstract：:Wnt/beta-catenin signaling controls various cell fates in metazoan development and is misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its transmembrane coreceptors inhibits phosphorylation and degradation of the transcriptional coactivator beta-catenin, which then translocates t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cselenyi CS,Jernigan KK,Tahinci E,Thorne CA,Lee LA,Lee E

更新日期：2008-06-10 00:00:00

abstract：:Damage to the protooncogene MYC has been implicated in the genesis of diverse human tumors, but the tumorigenic potential of the isolated gene has been disputed. Here we report the use of a retroviral vector to test the potency of human MYC for neoplastic transformation in avian cells. We found that sustained and abun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsay GM,Moscovici G,Moscovici C,Bishop JM

更新日期：1990-03-01 00:00:00

abstract：:Intercropping, which grows at least two crop species on the same pieces of land at the same time, can increase grain yields greatly. Legume-grass intercrops are known to overyield because of legume nitrogen fixation. However, many agricultural soils are deficient in phosphorus. Here we show that a new mechanism of ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li SM,Sun JH,Zhou LL,Bao XG,Zhang HG,Zhang FS

更新日期：2007-07-03 00:00:00

abstract：:Cell-free extracts of nifF and nifJ mutants of Klebsiella pneumoniae are unable to couple acetylene reduction (N2 fixation) by nitrogenase to the oxidation of organic metabolites. However, nifF and nifJ mutants can complement each other in vitro to establish the coupling. This indicates that the products of the nifF a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nieva-Gómez D,Roberts GP,Klevickis S,Brill WJ

更新日期：1980-05-01 00:00:00

abstract：:C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30% decrease in the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallorga P,Tallman JF,Henneberry RC,Hirata F,Strittmatter WT,Axelrod J

更新日期：1980-03-01 00:00:00

abstract：:The treatment of PC12 cells with either nerve growth factor or phorbol 12-myristate 13-acetate caused a decrease in the phosphorylation of a soluble 100-kDa protein (Nsp100). After treatment with nerve growth factor, the activity of Ca2+/phospholipid-dependent protein kinase (protein kinase C) in the cytosol was incre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hama T,Huang KP,Guroff G

更新日期：1986-04-01 00:00:00

abstract：:Sinuous patterns traced by fluid flows are a ubiquitous feature of physical landscapes on Earth, Mars, the volcanic floodplains of the Moon and Venus, and other planetary bodies. Typically discussed as a consequence of migration processes in meandering rivers, sinuosity is also expressed in channel types that show lit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lazarus ED,Constantine JA

更新日期：2013-05-21 00:00:00

abstract：:Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-kappaB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-kappaB signaling through IkappaB-kinase (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egan LJ,Eckmann L,Greten FR,Chae S,Li ZW,Myhre GM,Robine S,Karin M,Kagnoff MF

更新日期：2004-02-24 00:00:00

abstract：:Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs during an infection, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aresta-Branco F,Sanches-Vaz M,Bento F,Rodrigues JA,Figueiredo LM

更新日期：2019-10-08 00:00:00

abstract：:Nonhomologous integration vectors have been used to demonstrate the feasibility of insertional mutagenesis in haploid tachyzoites of the protozoan parasite Toxoplasma gondii. Mutant clones resistant to 5-fluorouracil were identified at a frequency of approximately 10(-6) (approximately 2 x 10(-5) of the stable transfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donald RG,Roos DS

更新日期：1995-06-06 00:00:00

abstract：:One of the factors required for the antiviral activity of the synthetic nucleoside, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is the ability of the molecule to adopt the substrate conformation specified by the enzyme for which it is a competitive inhibitor, inosine 5'-phosphate dehydrogenase (IM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DL,Miles DW,Redington P,Eyring H

更新日期：1976-12-01 00:00:00

abstract：:The histidine decarboxylase (L-histidine carboxylase, EC 4.1.1.22) activity of whole W/W mouse embryos, which are devoid of mast cells, remained very low and did not show the rapid increase before birth (17-20 days of gestation) seen in wild-type +/+ embryos. During the same period, the histamine content also remained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe T,Kitamura Y,Maeyama K,Go S,Yamatodani A,Wada H

更新日期：1981-07-01 00:00:00

abstract：:An inborn deficiency in the ability of aldolase B to split fructose 1-phosphate is found in humans with hereditary fructose intolerance (HFI). A stable isotope procedure to elucidate the mechanism of conversion of fructose to glucose in normal children and in HFI children has been developed. A constant infusion of D-[...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gopher A,Vaisman N,Mandel H,Lapidot A

更新日期：1990-07-01 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:Water-biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Persson E,Halle B

更新日期：2008-04-29 00:00:00