Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.

abstract：:I reject the Darwinian assumption that larvae and their adults evolved from a single common ancestor. Rather I posit that, in animals that metamorphose, the basic types of larvae originated as adults of different lineages, i.e., larvae were transferred when, through hybridization, their genomes were acquired by distan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williamson DI

更新日期：2009-11-24 00:00:00

abstract：:The temporal dynamics of electrical activity in an olfactory organ, the procerebral lobe of the terrestrial mollusc Limax maximus, is studied. The lobe exhibits intrinsic oscillations in its field potential. Intracellular recordings show that the lobe contains two classes of neurons, both with activity phase-locked to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaney KR,Gelperin A,Fee MS,Flores JA,Gervais R,Tank DW,Kleinfeld D

更新日期：1994-01-18 00:00:00

abstract：:cDNA clones corresponding to the polypeptide that has been shown to be an endogenous diazepam binding inhibitor and may act as a physiological ligand for the benzodiazepine/beta-carboline receptor have been isolated from bacteriophage lambda recombinant libraries from rat hypothalamus, total brain, and liver. The clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mocchetti I,Einstein R,Brosius J

更新日期：1986-10-01 00:00:00

abstract：:Domesticated maize and its wild ancestor (teosinte) differ strikingly in morphology and afford an opportunity to examine the connection between strong selection and diversity in a major crop species. The tb1 gene largely controls the increase in apical dominance in maize relative to teosinte, and a region of the tb1 l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark RM,Linton E,Messing J,Doebley JF

更新日期：2004-01-20 00:00:00

abstract：:Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same aggluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burger MM

更新日期：1969-03-01 00:00:00

abstract：:Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strittmatter WJ,Roses AD

更新日期：1995-05-23 00:00:00

abstract：:The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme (E2) that is required for DNA repair, damage-induced mutagenesis, and sporulation. We have cloned the two human RAD6 homologs, designated HHR6A and HHR6B. The two 152-amino acid human proteins share 95% sequence identity with each other a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koken MH,Reynolds P,Jaspers-Dekker I,Prakash L,Prakash S,Bootsma D,Hoeijmakers JH

更新日期：1991-10-15 00:00:00

abstract：:Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Park JH,Kim J,Kim JJ,Hong S,Kim J,Kim JH,Woo HR,Hyeon C,Lim PO,Nam HG,Hwang D

更新日期：2018-05-22 00:00:00

abstract：:The use of matching variable number of tandem repeat (VNTR) profiles to link suspects with crimes is potentially very powerful, but it has been quite controversial. Initial debate over laboratory procedures has largely given way to debate over the statistical and population genetic issues involved in calculating the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weir BS

更新日期：1992-12-15 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:Developing autoreactive B cells edit their B cell antigen receptor (BCR) in the bone marrow and are clonally deleted when they fail to reexpress an innocent BCR. Here, inducible Cre-loxP-mediated gene inversion is used to change the specificity of the BCR on mature IgM+ IgD+ B cells in vivo to address the fate of lymp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lam KP,Rajewsky K

更新日期：1998-10-27 00:00:00

abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper G,Rios AC

更新日期：2016-06-14 00:00:00

abstract：:Let t --> gamma(t) be a homogeneous curve in R(n). For suitable f, define [unk](f)(x) = sup(h > 0)|(1/h) [unk](0) (h)f(x - gamma(t)) dt|. Then parallel[unk](f) parallel(p)

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM

更新日期：1976-07-01 00:00:00

abstract：:The term amyloid defines a group of proteins that aggregate into plaques or fibers. Amyloid fibers gained their fame mostly due to their relation with neurodegenerative diseases in humans. However, secreted by lower organisms, such as bacteria and fungi, amyloid fibers play a functional role: for example, when they se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lester-Zer N,Ghrayeb M,Chai L

更新日期：2019-11-05 00:00:00

abstract：:Sera from 30 patients with astrocytoma were tested for antibody reacting with cell surface antigens of cultured autologous astrocytoma cells. Ten percent of the patients had antibody detectable by mixed hemadsorption assays, approximately 50% by immune adherence and protein A assays, and 100% by anti-C3-mixed hemadsor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfreundschuh M,Shiku H,Takahashi T,Ueda R,Ransohoff J,Oettgen HF,Old LJ

更新日期：1978-10-01 00:00:00

abstract：:The structure of activated pig heart aconitase [citrate(isocitrate) hydro-lyase, EC 4.2.1.3] containing a [4Fe-4S] cluster has been refined at 2.5-A resolution to a crystallographic residual of 18.2%. Comparison of this structure to the recently determined 2.1-A resolution structure of the inactive enzyme containing a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins AH,Stout CD

更新日期：1989-05-01 00:00:00

abstract：:The sequences of large insert clones containing genomic DNA that is orthologous to the maize adh1 region were obtained for sorghum, rice, and the adh1-homoeologous region of maize, a remnant of the tetraploid history of the Zea lineage. By using all four genomes, it was possible to describe the nature, timing, and lin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ilic K,SanMiguel PJ,Bennetzen JL

更新日期：2003-10-14 00:00:00

abstract：:We demonstrate that the BC200 RNA gene, which encodes a neural small cytoplasmic RNA, is a member of the most prodigious family of interspersed repetitive DNA and that its product represents an example of a primate tissue-specific RNA polymerase III transcript. The BC200 RNA gene is an early monomeric member and one o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martignetti JA,Brosius J

更新日期：1993-12-15 00:00:00

abstract：:Maintenance of genome stability is carried out by a suite of DNA repair pathways that ensure the repair of damaged DNA and faithful replication of the genome. Of particular importance are the repair pathways, which respond to DNA double-strand breaks (DSBs), and how the efficiency of repair is influenced by sequence h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer D,Fu BX,Heyer WD

更新日期：2015-12-15 00:00:00

abstract：:The relatively short read lengths associated with the most cost-effective DNA sequencing technologies have limited their use in de novo genome assembly, structural variation detection, and haplotype-resolved genome sequencing. Consequently, there is a strong need for methods that capture various scales of contiguity i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JJ,Lee C,Hiatt JB,Adey A,Shendure J

更新日期：2012-11-13 00:00:00

abstract：:In spite of the diversity of possible biological forms observed in nature, a limited range of morphospace is frequently occupied for a given trait. Several mechanisms have been proposed to explain this bias in the distribution of phenotypes including selection, drift, and developmental constraints. Despite extensive w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malagón JN,Ahuja A,Sivapatham G,Hung J,Lee J,Muñoz-Gómez SA,Atallah J,Singh RS,Larsen E

更新日期：2014-09-30 00:00:00

abstract：:Murine embryonal carcinoma (EC) cells are refractory to infection by retroviruses because retroviral long terminal repeat (LTR) enhancers have little activity in EC cells. A previous report described the isolation of clonal EC cell lines that express the integrated neomycin-resistance gene (neo) linked to the Moloney ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taketo M,Tanaka M

更新日期：1987-06-01 00:00:00

abstract：:The fusiform face area (FFA) is a region of human cortex that responds selectively to faces, but whether it supports a more general function relevant for perceptual expertise is debated. Although both faces and objects of expertise engage many brain areas, the FFA remains the focus of the strongest modular claims and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGugin RW,Gatenby JC,Gore JC,Gauthier I

更新日期：2012-10-16 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Determination of the primary structure of this protein should be of importance for understanding the functional role it plays in ast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeves SA,Helman LJ,Allison A,Israel MA

更新日期：1989-07-01 00:00:00

abstract：:Interleukin 6 (IL-6) is a cytokine that acts on various cell types. Here we show that IL-6 mRNA is produced in vivo in two self-limiting physiologic angiogenic processes: (i) the formation of the vascular system accompanying development of ovarian follicles and (ii) the formation of a capillary network in the maternal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motro B,Itin A,Sachs L,Keshet E

更新日期：1990-04-01 00:00:00

abstract：:Two new forms of carboxypeptidase B have been isolated from spontaneously activated bovine pancreatic juice. The fully active enzymes contain an internal split at residues 92-93 and 95-96, respectively. Sequenator analysis of the amino terminal segments of the two chains of the enzyme has extended the sequence informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeck GR,Walsh KA,Hermodson MA,Neurath H

更新日期：1971-06-01 00:00:00

abstract：:The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERalpha and ERbeta. We demonstrated previously that estrogen inhibits the response to vascular injury in both wild-type an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karas RH,Hodgin JB,Kwoun M,Krege JH,Aronovitz M,Mackey W,Gustafsson JA,Korach KS,Smithies O,Mendelsohn ME

更新日期：1999-12-21 00:00:00

abstract：:The emerging picture of Earth's deep interior from seismic tomography indicates more complexity than previously thought. The presence of lateral anisotropy and heterogeneity in Earth's mantle highlights the need for fully anisotropic elasticity data from mineral physics. A breakthrough in high-frequency (gigahertz) ul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobsen SD,Spetzler H,Reichmann HJ,Smyth JR

更新日期：2004-04-20 00:00:00

abstract：:Since the end of World War II, much evidence has accrued of the primary phase of village-farming community life in Southwestern Asia, which began about 7000 B.C. The remains of (usually) several of the positively domesticated animals (dog, sheep, goat, pig) and plants (wheat, barley, legumes such as peas and lentils) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braidwood RJ,Cambel H,Redman CL,Watson PJ

更新日期：1971-06-01 00:00:00

abstract：:The utilization of the isoaccepting species of leucyl-tRNA in protein synthesis has been examined in E. coli. Two minor leucyl-tRNA species, isoacceptors tRNA3Leu and tRNA4Leu, are the predominant species found bound to ribosomes during exponential growth in minimal medium. In rich medium, an increased proportion of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes WM,Goldman E,Miner TA,Hatfield GW

更新日期：1977-04-01 00:00:00