Abstract:
:The protective effects of estrogen in the cardiovascular system result from both systemic effects and direct actions of the hormone on the vasculature. Two estrogen receptors have been identified, ERalpha and ERbeta. We demonstrated previously that estrogen inhibits the response to vascular injury in both wild-type and ERalpha-deficient mice, and that ERbeta is expressed in the blood vessels of each, suggesting a role for ERbeta in the vascular protective effects of estrogen. In the present study, we examined the effect of estrogen administration on mouse carotid arterial injury in ERbeta-deficient mice. Surprisingly, in ovariectomized female wild-type and ERbeta knockout mice, 17beta-estradiol markedly and equally inhibited the increase in vascular medial area and the proliferation of vascular smooth muscle cells after vascular injury. These data demonstrate that ERbeta is not required for estrogen-mediated inhibition of the response to vascular injury, and suggest that either of the two known estrogen receptors is sufficient to protect against vascular injury, or that another unidentified estrogen receptor mediates the vascular protective effects of estrogen.
journal_name
Proc Natl Acad Sci U S Aauthors
Karas RH,Hodgin JB,Kwoun M,Krege JH,Aronovitz M,Mackey W,Gustafsson JA,Korach KS,Smithies O,Mendelsohn MEdoi
10.1073/pnas.96.26.15133keywords:
subject
Has Abstractpub_date
1999-12-21 00:00:00pages
15133-6issue
26eissn
0027-8424issn
1091-6490journal_volume
96pub_type
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