当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Sparse bursts optimize information transmission in a multiplexed neural code.

Sparse bursts optimize information transmission in a multiplexed neural code.

Abstract：

:Many cortical neurons combine the information ascending and descending the cortical hierarchy. In the classical view, this information is combined nonlinearly to give rise to a single firing-rate output, which collapses all input streams into one. We analyze the extent to which neurons can simultaneously represent multiple input streams by using a code that distinguishes spike timing patterns at the level of a neural ensemble. Using computational simulations constrained by experimental data, we show that cortical neurons are well suited to generate such multiplexing. Interestingly, this neural code maximizes information for short and sparse bursts, a regime consistent with in vivo recordings. Neurons can also demultiplex this information, using specific connectivity patterns. The anatomy of the adult mammalian cortex suggests that these connectivity patterns are used by the nervous system to maintain sparse bursting and optimal multiplexing. Contrary to firing-rate coding, our findings indicate that the physiology and anatomy of the cortex may be interpreted as optimizing the transmission of multiple independent signals to different targets.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Naud R,Sprekeler H

doi

10.1073/pnas.1720995115

subject

Has Abstract

pub_date

2018-07-03 00:00:00

pages

E6329-E6338

issue

27

eissn

0027-8424

issn

1091-6490

pii

1720995115

journal_volume

115

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • NMR structures of three single-residue variants of the human prion protein.

    abstract：:The NMR structures of three single-amino acid variants of the C-terminal domain of the human prion protein, hPrP(121-230), are presented. In hPrP(M166V) and hPrP(R220K) the substitution is with the corresponding residue in murine PrP, and in hPrP(S170N) it is with the corresponding Syrian hamster residue. All three su...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.15.8340

    authors： Calzolai L,Lysek DA,Guntert P,von Schroetter C,Riek R,Zahn R,Wüthrich K

    更新日期：2000-07-18 00:00:00

  • Metaphase and interphase fluorescence in situ hybridization mapping of the rice genome with bacterial artificial chromosomes.

    abstract：:Fluorescence in situ hybridization (FISH) is a powerful tool for physical mapping in human and other mammalian species. However, application of the FISH technique has been limited in plant species, especially for mapping single- or low-copy DNA sequences, due to inconsistent signal production in plant chromosome prepa...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.10.4487

    authors： Jiang J,Gill BS,Wang GL,Ronald PC,Ward DC

    更新日期：1995-05-09 00:00:00

  • Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport.

    abstract：:Modulation of cholesterol absorption in the intestine, the primary site of dietary cholesterol uptake in humans, can have profound clinical implications. We have undertaken a reverse genetic approach by disrupting putative cholesterol processing genes in zebrafish larvae by using morpholino (MO) antisense oligonucleot...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,收录出版

    doi：10.1073/pnas.0400441101

    authors： Smart EJ,De Rose RA,Farber SA

    更新日期：2004-03-09 00:00:00

  • Apparent dependence of interactions between cytochrome b5 and cytochrome b5 reductase upon translational diffusion in dimyristoyl lecithin liposomes.

    abstract：:Dimyristoyl lecithin liposomes, containing cytochrome b5 reductase (NADH:ferricytochrome b5 oxidoreductase, EC 1.6.2.2) and varying amounts of cytochrome b5, were used to measure flavoprotein catalysis alone and catalysis requiring electron transfer between the reductase and cytochrome as a function of temperature. Wh...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.72.7.2658

    authors： Strittmatter P,Rogers MJ

    更新日期：1975-07-01 00:00:00

  • Kinetics of mature T-cell development in the thymus.

    abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.7.2579

    authors： Egerton M,Scollay R,Shortman K

    更新日期：1990-04-01 00:00:00

  • Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.

    abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to more serious invasive infections. We adapted a mouse model of CAUTI to investigate how catheterization increases an individual's susceptibility to MRSA UTI. Thi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1707572114

    authors： Walker JN,Flores-Mireles AL,Pinkner CL,Schreiber HL 4th,Joens MS,Park AM,Potretzke AM,Bauman TM,Pinkner JS,Fitzpatrick JAJ,Desai A,Caparon MG,Hultgren SJ

    更新日期：2017-10-10 00:00:00

  • Ras activity regulates cyclin E degradation by the Fbw7 pathway.

    abstract：:The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis. Fbw7 is a human tumor suppressor that is targeted for mutation in primary cancers. However, mechanisms other than mutat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0503677102

    authors： Minella AC,Welcker M,Clurman BE

    更新日期：2005-07-05 00:00:00

  • The regulation of DNA synthesis in quiescent lymphocytes by cytoplasmic inhibitors.

    abstract：:We previously have shown that proliferating lymphoid cells contain an extractable cytoplasmic protein that is capable of inducing DNA synthesis in isolated quiescent nuclei (activator of DNA replication, ADR). ADR is present in continuously proliferating (transformed) lymphoblastoid cell lines and in mitogen- or inter...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.15.5160

    authors： Gutowski JK,West A,Cohen S

    更新日期：1985-08-01 00:00:00

  • Spatiotemporal reaction kinetics of an ultrafast photoreaction pathway visualized by time-resolved liquid x-ray diffraction.

    abstract：:We have studied the reaction dynamics for HgI(2) in methanol by using time-resolved x-ray diffraction (TRXD). Although numerous time-resolved spectroscopic studies have provided ample information about the early dynamics of HgI(2), a comprehensive reaction mechanism in the solution phase spanning from picoseconds up t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0601958103

    authors： Kim TK,Lorenc M,Lee JH,Lo Russo M,Kim J,Cammarata M,Kong Q,Noel S,Plech A,Wulff M,Ihee H

    更新日期：2006-06-20 00:00:00

  • Change in nuclear potassium electrochemical activity and puffing of potassium-sensitive salivary chromosome regions during Chironomus development.

    abstract：:Changes in nuclear K+ electrochemical activity and total nuclear K+ content in salivary glands of Chironomus tentans were measured with ion-selective microelectrodes based on valinomycin and with flameless atomic absorption spectrometry, respectively. The K+ activity increased by a factor of 2.6 and the total K+, by a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.2.806

    authors： Wuhrmann P,Ineichen H,Riesen-Willi U,Lezzi M

    更新日期：1979-02-01 00:00:00

  • Three-dimensional scroll waves organize Dictyostelium slugs.

    abstract：:To test the hypothesis that periodic signals and chemotaxis direct later morphogenesis in Dictyostelium discoideum, we investigated cell behavior and cell movement in slugs. Trails of neutral red-stained prestalk and anterior-like cells were recorded by high-resolution digital image processing. Neutral red-stained ant...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.14.6433

    authors： Siegert F,Weijer CJ

    更新日期：1992-07-15 00:00:00

  • Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen.

    abstract：:Confluent cultures of human fetal lung fibroblasts degrade approximately 10% of their newly synthesized collagen within the cell prior to secretion. This basal level of intracellular degradation could not be inhibited by colchicine or cytochalasin B, inhibitors of microtubular and microfilament function, respectively,...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.8.4746

    authors： Berg RA,Schwartz ML,Crystal RG

    更新日期：1980-08-01 00:00:00

  • One-step generation of cytoplasmic male sterility by fusion of mitochondrial-inactivated tomato protoplasts with nuclear-inactivated Solanum protoplasts.

    abstract：:Mesophyll protoplasts of Lycopersicon esculentum were treated with iodoacetamide to inactivate mitochondria, and protoplasts of Solanum acaule and Solanum tuberosum were irradiated with gamma- or x-rays to inactivate nuclei. Mixtures of protoplasts thus modified were treated with Ca2+ and polyethylene glycol to obtain...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.15.6832

    authors： Melchers G,Mohri Y,Watanabe K,Wakabayashi S,Harada K

    更新日期：1992-08-01 00:00:00

  • Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1.

    abstract：:The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG and KCNE1, but the precise mechanisms remain unclear. To clarify this situation we injected adenoviral vectors expressing wild-type or LQT mutants of HERG and KC...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.091239098

    authors： Hoppe UC,Marbán E,Johns DC

    更新日期：2001-04-24 00:00:00

  • Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.

    abstract：:The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the sa...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.11.7219

    authors： Goldstein A,Fischli W,Lowney LI,Hunkapiller M,Hood L

    更新日期：1981-11-01 00:00:00

  • High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.

    abstract：:2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and IFN-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.24.11455

    authors： McKendry R,John J,Flavell D,Müller M,Kerr IM,Stark GR

    更新日期：1991-12-15 00:00:00

  • Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

    abstract：:Plasma membrane insulin receptors, affinity labeled by covalent crosslinking to receptor-bound 125I-labeled insulin, are shown to appear as a heterogeneous population of three major disulfide-linked complexes (Mr 350,000, 320,000, and 290,000) upon electrophoresis in highly porous dodecyl sulfate/polyacrylamide gels i...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.12.7137

    authors： Massague J,Pilch PF,Czech MP

    更新日期：1980-12-01 00:00:00

  • Ferroelectric switching of elastin.

    abstract：:Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology has never been firmly established. Here, we present compelling evidence that elastin, the key ECM protein found in connective tissues, is ferroelectric, and we elucidate the molecular mechanism of i...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1402909111

    authors： Liu Y,Cai HL,Zelisko M,Wang Y,Sun J,Yan F,Ma F,Wang P,Chen QN,Zheng H,Meng X,Sharma P,Zhang Y,Li J

    更新日期：2014-07-08 00:00:00

  • Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

    abstract：:Representational difference analysis was used to search for pathogens in multiple sclerosis brains. We detected a 341-nucleotide fragment that was 99.4% identical to the major DNA binding protein gene of human herpesvirus 6 (HHV-6). Examination of 86 brain specimens by PCR demonstrated that HHV-6 was present in > 70% ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 临床试验,杂志文章

    doi：10.1073/pnas.92.16.7440

    authors： Challoner PB,Smith KT,Parker JD,MacLeod DL,Coulter SN,Rose TM,Schultz ER,Bennett JL,Garber RL,Chang M

    更新日期：1995-08-01 00:00:00

  • An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci.

    abstract：:The blanket resistance of methicillin-resistant Staphylococcus aureus to all beta-lactam antibiotics--which had such a devastating impact on chemotherapy of staphylococcal infections--is related to the properties of the key component of this resistance mechanism: the "acquired" penicillin-binding protein (PBP)-2A, whi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.191260798

    authors： Pinho MG,de Lencastre H,Tomasz A

    更新日期：2001-09-11 00:00:00

  • Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice.

    abstract：:During the analysis of liver protein expression in the offspring of male mice irradiated with fission-spectrum neutrons, one offspring displayed a heritable 50% decrease in the abundance of two proteins. Homozygous mice lacking detectable quantities of these proteins were obtained through breeding. Characterization of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.24.11338

    authors： Champion KM,Cook RJ,Tollaksen SL,Giometti CS

    更新日期：1994-11-22 00:00:00

  • Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.

    abstract：:Germinal centers (GCs) are specialized microenvironments in secondary lymphoid organs where high-affinity antibody-producing B cells are selected based on B-cell antigen receptor (BCR) signal strength. BCR signaling required for normal GC selection is uncertain. We have found that protein kinase N1 (PKN1, also known a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1218925110

    authors： Yasui T,Sakakibara-Yada K,Nishimura T,Morita K,Tada S,Mosialos G,Kieff E,Kikutani H

    更新日期：2012-12-18 00:00:00

  • Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space.

    abstract：:Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only pr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1815791116

    authors： Helbert W,Poulet L,Drouillard S,Mathieu S,Loiodice M,Couturier M,Lombard V,Terrapon N,Turchetto J,Vincentelli R,Henrissat B

    更新日期：2019-03-26 00:00:00

  • neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation.

    abstract：:The protein encoded by the neu protooncogene (human gene symbol NGL for neuro/glioblastoma-derived) is a member of the surface receptor/tyrosine kinase family. Though its structure suggests that it can transduce a transmembrane signal, neither its extracellular ligand nor its critical intracellular substrates are know...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.21.8057

    authors： Flanagan JG,Leder P

    更新日期：1988-11-01 00:00:00

  • Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cultivation in Asia.

    abstract：:Flowering time (i.e., heading date in crops) is an important ecological trait that determines growing seasons and regional adaptability of plants to specific natural environments. Rice (Oryza sativa L.) is a short-day plant that originated in the tropics. Increasing evidence suggests that the northward expansion of cu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1213962110

    authors： Wu W,Zheng XM,Lu G,Zhong Z,Gao H,Chen L,Wu C,Wang HJ,Wang Q,Zhou K,Wang JL,Wu F,Zhang X,Guo X,Cheng Z,Lei C,Lin Q,Jiang L,Wang H,Ge S,Wan J

    更新日期：2013-02-19 00:00:00

  • Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

    abstract：:We find that histidine residues in proteins are major targets for reaction with the lipid peroxidation product 4-hydroxynon-2-enal (HNE). Reaction of insulin (which contains no sulfhydryl groups) with HNE leads to the generation of HNE-protein adducts, which are converted to radioactive derivatives upon subsequent tre...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.10.4544

    authors： Uchida K,Stadtman ER

    更新日期：1992-05-15 00:00:00

  • Overexpression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma.

    abstract：:Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that accurately reflects their clinical malignant status in the original host. Thus, such a system allows a unique opportunity to analyze the genetic events involved in the c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.22.9047

    authors： Theodorescu D,Cornil I,Fernandez BJ,Kerbel RS

    更新日期：1990-11-01 00:00:00

  • Recognition of the muscarinic receptor by its endogenous neurotransmitter: binding of [3H]acetylcholine and its modulation by transition metal ions and guanine nucleotides.

    abstract：:Agonist binding to the muscarinic receptor in rat cerebral cortex membranes was studied by using the neurotransmitter itself, [3H]acetylcholine [( 3H]AcCho). By using 10 microM atropine or oxotremorine to define specific binding, it was possible to demonstrate specific binding of [3H]AcCho that was sensitive to muscar...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.12.3650

    authors： Gurwitz D,Kloog Y,Sokolovsky M

    更新日期：1984-06-01 00:00:00

  • Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.

    abstract：:We have isolated and sequenced cDNA clones corresponding to the DR beta 1 and DR beta 2 loci from two homozygous B-cell lines typed as DR7 (Burkhart) and DR9 (ISK). These nucleotide sequences were compared to beta 1 and beta 2 chains of other DR haplotypes. The first-domain sequences of beta 2 chains are identical in ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.23.9149

    authors： Gregersen PK,Moriuchi T,Karr RW,Obata F,Moriuchi J,Maccari J,Goldberg D,Winchester RJ,Silver J

    更新日期：1986-12-01 00:00:00

  • Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.

    abstract：:Bone morphogenetic protein (BMP) signaling plays a major role in dorsoventral patterning in vertebrates and in Drosophila. Remarkably, in Tribolium, a beetle with an ancestral type of insect development, early BMP/dpp exhibits differential expression along the anteroposterior axis. However, the BMP/Dpp inhibitor Sog/c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0605154103

    authors： van der Zee M,Stockhammer O,von Levetzow C,Nunes da Fonseca R,Roth S

    更新日期：2006-10-31 00:00:00