当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.

Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.

Abstract：

:Bone morphogenetic protein (BMP) signaling plays a major role in dorsoventral patterning in vertebrates and in Drosophila. Remarkably, in Tribolium, a beetle with an ancestral type of insect development, early BMP/dpp exhibits differential expression along the anteroposterior axis. However, the BMP/Dpp inhibitor Sog/chordin is expressed ventrally and establishes a dorsal domain of BMP/Dpp activity by transporting BMPs toward the dorsal side, like in Drosophila. Loss of Tribolium Sog not only abolishes dorsoventral polarity in the ectoderm, but also leads to the complete absence of the CNS. This phenotype suggests that sog is the main BMP antagonist in Tribolium, in contrast to vertebrates and Drosophila, which possess redundant antagonists. Surprisingly, Sog also is required for head formation in Tribolium, as are the BMP antagonists in vertebrates. Thus, in Tribolium, the system of BMP and its antagonists is less complex than in Drosophila or vertebrates and combines features from both, suggesting that it might represent an ancestral state.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

van der Zee M,Stockhammer O,von Levetzow C,Nunes da Fonseca R,Roth S

doi

10.1073/pnas.0605154103

subject

Has Abstract

pub_date

2006-10-31 00:00:00

pages

16307-12

issue

44

eissn

0027-8424

issn

1091-6490

pii

0605154103

journal_volume

103

pub_type

杂志文章

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