Glucocorticoid receptor-dependent disruption of a specific nucleosome on the mouse mammary tumor virus promoter is prevented by sodium butyrate.

abstract：:Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharp DJ,Bonnelle V,De Boissezon X,Beckmann CF,James SG,Patel MC,Mehta MA

更新日期：2010-03-30 00:00:00

abstract：:Human thioredoxin reductase (TR) contains selenocysteine (Secys) in a redox center [cysteine (Cys)-497,Secys-498] near the C-terminus. The essential role of Secys in TR isolated from HeLa cells was demonstrated by the alkylation studies. Reaction of native NADPH reduced enzyme with bromoacetate at pH 6.5 inhibited enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorlatov SN,Stadtman TC

更新日期：1998-07-21 00:00:00

abstract：:Saccharomyces cerevisiae strains expressing the activated RAS2Val19 gene or lacking both cAMP phosphodiesterase genes, PDE1 and PDE2, have impaired growth control and display an acute sensitivity to heat shock. We have isolated two classes of mammalian cDNAs from yeast expression libraries that suppress the heat shock...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colicelli J,Nicolette C,Birchmeier C,Rodgers L,Riggs M,Wigler M

更新日期：1991-04-01 00:00:00

abstract：:Lithium ion at concentrations between 2 and 20 mM simulated the stimulatory effects of insulin on the uptake of alpha-aminoisobutyric acid, synthesis of RNA and DNA, and cell multiplication in mouse mammary gland explants cultured in a chemically defined synthetic medium. Other monovalent cations were virtually ineffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hori C,Oka T

更新日期：1979-06-01 00:00:00

abstract：:Based on structural information derived from the F NMR data of labeled rhodopsins, rhodopsin crystal structure, and excited-state properties of model polyenes, we propose a molecular mechanism that accounts specifically for the causes of the well-known enhanced photoreactivity of rhodopsin (increased rates and quantum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RS,Colmenares LU

更新日期：2003-12-09 00:00:00

abstract：:Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramanian R,Choi JH,Francescatto L,Willer J,Horton ER,Asimacopoulos EP,Stankovic KM,Plummer L,Buck CL,Quinton R,Nebesio TD,Mericq V,Merino PM,Meyer BF,Monies D,Gusella JF,Al Tassan N,Katsanis N,Crowley WF Jr

更新日期：2014-12-16 00:00:00

abstract：:Septins assemble into filaments and higher-order structures that act as scaffolds for diverse cell functions including cytokinesis, cell polarity, and membrane remodeling. Despite their conserved role in cell organization, little is known about how septin filaments elongate and are knitted together into higher-order a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridges AA,Zhang H,Mehta SB,Occhipinti P,Tani T,Gladfelter AS

更新日期：2014-02-11 00:00:00

abstract：:Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikoshkov A,Drakenberg K,Wang X,Horvath MC,Keller E,Hurd YL

更新日期：2008-01-15 00:00:00

abstract：:The interrelationships of hexose feeding and insulin action were studied in the Chinese hamster fibroblast cell lines 023 and DS-7. The latter, derived from 023 and deficient in phosphoglucose isomerase, has been used to map the metabolic requirements for aldohexose-mediated down-regulation or "curbing" of hexose tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson C,Peterson SW,Ullrey DB,Kalckar HM

更新日期：1986-06-01 00:00:00

abstract：:The RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase EC 2.7.7.7) of avian oncornavirus requires a tryptophan tRNA (tRNATrp) primer molecule located close to the 5' end of the viral RNA genome for the initiation of DNA synthesis in vitro. In this communication we demonstrate that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collett MS,Faras AJ

更新日期：1976-04-01 00:00:00

abstract：:Explaining the maintenance of tropical forest diversity under the countervailing forces of drift and competition poses a major challenge to ecological theory. Janzen-Connell effects, in which host-specific natural enemies restrict the recruitment of juveniles near conspecific adults, provide a potential mechanism. Jan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi T,Barfield M,Barrantes S,Sullivan C,Holt RD,Terborgh J

更新日期：2019-01-08 00:00:00

abstract：:To determine which of seven library design algorithms best introduces new protein function without destroying it altogether, seven combinatorial libraries of green fluorescent protein variants were designed and synthesized. Each was evaluated by distributions of emission intensity and color compiled from measurements ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Treynor TP,Vizcarra CL,Nedelcu D,Mayo SL

更新日期：2007-01-02 00:00:00

abstract：:The strikingly high incidence of obstructed labor due to the disproportion of fetal size and the mother's pelvic dimensions has puzzled evolutionary scientists for decades. Here we propose that these high rates are a direct consequence of the distinct characteristics of human obstetric selection. Neonatal size relativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitteroecker P,Huttegger SM,Fischer B,Pavlicev M

更新日期：2016-12-20 00:00:00

abstract：:Scientific and engineering innovation is vital for American competitiveness, quality of life, and national security. However, too few American students, especially women, pursue these fields. Although this problem has attracted enormous attention, rigorously tested interventions outside artificial laboratory settings ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennehy TC,Dasgupta N

更新日期：2017-06-06 00:00:00

abstract：:The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams A,Lee GR,Spilianakis CG,Hwang SS,Eisenbarth SC,Flavell RA

更新日期：2013-04-23 00:00:00

abstract：:Plasmid pT181 is a 4437-base-pair, multicopy plasmid of Staphylococcus aureus that encodes tetracycline resistance. The replication of the leading strand of pT181 DNA initiates by covalent extension of a site-specific nick generated by the initiator protein at the origin of replication and proceeds by an asymmetric ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birch P,Khan SA

更新日期：1992-01-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

更新日期：1997-12-23 00:00:00

abstract：:C1q, a member of the immune complement cascade, is implicated in the selective pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown to occur during brain development, while increased activation and complement-dependent synapse loss is observed in neurodegenerative diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Györffy BA,Kun J,Török G,Bulyáki É,Borhegyi Z,Gulyássy P,Kis V,Szocsics P,Micsonai A,Matkó J,Drahos L,Juhász G,Kékesi KA,Kardos J

更新日期：2018-06-12 00:00:00

abstract：:We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbekian V,Lipinski MJ,Briley-Saebo KC,Amirbekian S,Aguinaldo JG,Weinreb DB,Vucic E,Frias JC,Hyafil F,Mani V,Fisher EA,Fayad ZA

更新日期：2007-01-16 00:00:00

abstract：:The bioluminescent bacterium Vibrio fischeri initiates a specific, persistent symbiosis in the light organ of the squid Euprymna scolopes. During the early stages of colonization, V. fischeri is exposed to host-derived nitric oxide (NO). Although NO can be both an antimicrobial component of innate immunity and a key s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Dufour YS,Carlson HK,Donohue TJ,Marletta MA,Ruby EG

更新日期：2010-05-04 00:00:00

abstract：:Current understanding of the integration of cell division and expansion in the development of plant lateral organs such as leaves is limited. Cell number is established during a mitotic phase, and subsequent growth into a mature organ relies primarily on cell expansion accompanied by endocycles. Here we show that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dewitte W,Scofield S,Alcasabas AA,Maughan SC,Menges M,Braun N,Collins C,Nieuwland J,Prinsen E,Sundaresan V,Murray JA

更新日期：2007-09-04 00:00:00

abstract：:Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the sensory hair cells. Individual stereocilia within each bundle contain a core of tightly packed actin filaments, whose length is dynamically regulated during developm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furness DN,Johnson SL,Manor U,Rüttiger L,Tocchetti A,Offenhauser N,Olt J,Goodyear RJ,Vijayakumar S,Dai Y,Hackney CM,Franz C,Di Fiore PP,Masetto S,Jones SM,Knipper M,Holley MC,Richardson GP,Kachar B,Marcotti W

更新日期：2013-08-20 00:00:00

abstract：:Histones play a crucial role in the organization of DNA in the nucleus, but their presence can prevent interactions with DNA binding proteins responsible for repair of DNA damage. Uracil is an abundant mutagenic lesion recognized by uracil DNA glycosylase (UDG) in the first step of base excision repair (BER). In nucle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinz JM,Rodriguez Y,Smerdon MJ

更新日期：2010-03-09 00:00:00

abstract：:Many marine bacteria have evolved to grow optimally at either high (copiotrophic) or low (oligotrophic) nutrient concentrations, enabling different species to colonize distinct trophic habitats in the oceans. Here, we compare the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauro FM,McDougald D,Thomas T,Williams TJ,Egan S,Rice S,DeMaere MZ,Ting L,Ertan H,Johnson J,Ferriera S,Lapidus A,Anderson I,Kyrpides N,Munk AC,Detter C,Han CS,Brown MV,Robb FT,Kjelleberg S,Cavicchioli R

更新日期：2009-09-15 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus 2 originated in Wuhan, China at the end of 2019 and rapidly spread in more than 100 countries. Researchers in different fields have been working on finding explanations for the unequal impact of the virus and deaths from the associated coronavirus disease 2019 (COVID-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arpino B,Bordone V,Pasqualini M

更新日期：2020-08-11 00:00:00

abstract：:The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LM,Bollum FJ

更新日期：1970-04-01 00:00:00

abstract：:Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS pinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu T,Wodrich MD,Scopelliti R,Corminboeuf C,Hu X

更新日期：2017-02-07 00:00:00

abstract：:Phyllosphere microbial communities were evaluated on leaves of field-grown plant species by culture-dependent and -independent methods. Denaturing gradient gel electrophoresis (DGGE) with 16S rDNA primers generally indicated that microbial community structures were similar on different individuals of the same plant sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Crowley DE,Borneman J,Keen NT

更新日期：2001-03-27 00:00:00

abstract：:The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an otherwise hydrophobic core. This layer has an undetermined function; it consists of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scales SJ,Yoo BY,Scheller RH

更新日期：2001-12-04 00:00:00