Association of functional nucleotide polymorphisms at DTH2 with the northward expansion of rice cultivation in Asia.

abstract：:Early passages of NIH 3T3 cells yield about 10 transformed foci for every 10(5) cells seeded after the cells multiply to confluence in a standardized 2-week assay. The question arose whether more cells would give rise to foci if given more time for their development. This question could not be answered simply by exten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow M,Yao A,Rubin H

更新日期：1994-01-18 00:00:00

abstract：:In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell function and survival. These carotenoid-derived compounds must combine with a protein moiety (the opsin) to establish functional visual pigments. Evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberhauser V,Voolstra O,Bangert A,von Lintig J,Vogt K

更新日期：2008-12-02 00:00:00

abstract：:Sera from 11 individuals which were classified as Lp(a-) by direct gel diffusion and by absorption tests showed the presence of Lp(a) lipoprotein when the sera were concentrated 120-fold. This Lp(a) antigen was demonstrated by gel diffusion to be indistinguishable from Lp-lipoprotein isolated from known Lp(a+) sera. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvie NR,Schultz JS

更新日期：1970-05-01 00:00:00

abstract：:Across phyla, the ribosomes-the central molecular machines for translation of genetic information-exhibit an overall preserved architecture and a conserved functional core. The natural heterogeneity of the ribosome periodically phases a debate on their functional specialization and the tissue-specific variations of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbeigiarab S,Kiani P,Velazquez Sanchez A,Krisp C,Kazantsev A,Fester L,Schlüter H,Ignatova Z

更新日期：2019-11-05 00:00:00

abstract：:Recent evidence indicates a specific role for vascular endothelial growth factor a (Vegfa) during artery development in both zebrafish and mouse embryos, whereas less is known about signals that govern vein formation. In zebrafish, loss of vegfa blocks segmental artery formation and reduces artery-specific gene expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Covassin LD,Villefranc JA,Kacergis MC,Weinstein BM,Lawson ND

更新日期：2006-04-25 00:00:00

abstract：:PH-30, a sperm surface protein involved in sperm-egg fusion, is composed of two subunits, alpha and beta, which are synthesized as precursors and processed, during sperm development, to yield the mature forms. The mature PH-30 alpha/beta complex resembles certain viral fusion proteins in membrane topology and predicte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfsberg TG,Bazan JF,Blobel CP,Myles DG,Primakoff P,White JM

更新日期：1993-11-15 00:00:00

abstract：:Bves is an integral membrane protein with no determined function and no homology to proteins outside of the Popdc family. It is widely expressed throughout development in myriad organisms. Here, we demonstrate an interaction between Bves and guanine nucleotide exchange factor T (GEFT), a GEF for Rho-family GTPases. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith TK,Hager HA,Francis R,Kilkenny DM,Lo CW,Bader DM

更新日期：2008-06-17 00:00:00

abstract：:Invariant natural killer T cell (NKT) cells (iNKT cells) produce both T-helper 1 (Th1) and T-helper 2 cytokines in response to α-Galactosylceramide (α-GalCer) stimulation and are thought to be the important effectors in the regulation of both innate and adaptive immunity involved in autoimmune disorders, microbial inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TN,Lin KH,Chang YJ,Huang JR,Cheng JY,Yu AL,Wong CH

更新日期：2011-10-18 00:00:00

abstract：:In Salmonella typhimurium, the CobU, CobS, CobT, and CobC proteins have been proposed to catalyze the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. This paper reports the in vitro assembly of the nucleotide loop of adenosylcobalamin from its precursors adenosylcobinam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maggio-Hall LA,Escalante-Semerena JC

更新日期：1999-10-12 00:00:00

abstract：:By using single-molecule multiparameter fluorescence detection, fluorescence resonance energy transfer experiments, and newly developed data analysis methods, this study demonstrates directly the existence of three structurally distinct forms of reverse transcriptase (RT):nucleic acid complexes in solution. Single-mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothwell PJ,Berger S,Kensch O,Felekyan S,Antonik M,Wöhrl BM,Restle T,Goody RS,Seidel CA

更新日期：2003-02-18 00:00:00

abstract：:Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorphism in hydrated and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cendrowska U,Silva PJ,Ait-Bouziad N,Müller M,Guven ZP,Vieweg S,Chiki A,Radamaker L,Kumar ST,Fändrich M,Tavanti F,Menziani MC,Alexander-Katz A,Stellacci F,Lashuel HA

更新日期：2020-03-24 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:The aggregation of the amyloid-β (Aβ) peptide is linked to the pathogenesis of Alzheimer's disease (AD). In particular, some point mutations within Aβ are associated with early-onset familial Alzheimer's disease. Here we set out to explore how the physical properties of the altered side chains, including their sizes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang X,Meisl G,Frohm B,Thulin E,Knowles TPJ,Linse S

更新日期：2018-06-26 00:00:00

abstract：:The regulation of cellular protein levels is a complex process involving many regulatory mechanisms, each introducing stochastic events, leading to variability of protein levels between isogenic cells. Previous studies have shown that perturbing genes involved in transcription regulation affects the amount of cell-to-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinott R,Jaimovich A,Friedman N

更新日期：2011-04-12 00:00:00

abstract：:Wild-type Escherichia coli cells grow normally in 95% O(2)/5% CO(2). In contrast, cells that cannot make polyamines because of mutations in the biosynthetic pathway are rapidly killed by incubation in 95% O(2)/5% CO(2). Addition of polyamines prevents the toxic effect of oxygen, permitting cell survival and optimal gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2003-03-04 00:00:00

abstract：:Vertebrate remains recovered from a limestone fissure filling on Antigua, Lesser Antilles, are associated with radiocarbon dates ranging from 4300 to 2500 yr B.P., contemporaneous with the earliest aboriginal human occupation of the island. Nine taxa of lizards, snakes, birds, bats, and rodents (one-third of the total...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steadman DW,Pregill GK,Olson SL

更新日期：1984-07-01 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

更新日期：2011-08-23 00:00:00

abstract：:Mammalian centromere function depends upon a specialized chromatin organization where distinct domains of CENP-A and dimethyl K4 histone H3, forming centric chromatin, are uniquely positioned on or near the surface of the chromosome. These distinct domains are embedded in pericentric heterochromatin (characterized by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greaves IK,Rangasamy D,Ridgway P,Tremethick DJ

更新日期：2007-01-09 00:00:00

abstract：:The five alpha genes of herpes simplex virus 1 are the first set of genes to be expressed after infection. Previous studies have shown that alpha genes resident in eukaryotic cells are induced by infection with herpes simplex virus 1 or 2 but not by other herpesviruses and indicate that the alpha trans-inducing factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellett PE,McKnight JL,Jenkins FJ,Roizman B

更新日期：1985-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) is known to bud from the inner membrane of the nuclear envelope. The structural gene for the glycoprotein gB, which is essential for virus entry and cell fusion induced by HSV type 1, has been cloned in a transient expression vector containing the adenovirus major late promoter, tripartite l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali MA,Butcher M,Ghosh HP

更新日期：1987-08-01 00:00:00

abstract：:Using Drosophila pseudoobscura, we tested the hypothesis that social constraints on the free expression of mate preferences, by both females and males, decrease offspring viability and reproductive success of mating pairs. Mate preference arenas eliminated intrasexual combat and intersexual coercion. The time female a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,Kim YK,Gowaty PA

更新日期：2007-03-13 00:00:00

abstract：:Blue mold of tobacco is caused by the fungus Peronospora tabacina. Its spores are released in the morning when the relative humidity falls, but they require free water for germination. Traditionally, the walls of the shade tents are raised to control the pathogen by drying leaves. We show that raising the walls does n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aylor DE,Taylor GS

更新日期：1982-01-01 00:00:00

abstract：:Infection by Plasmodium, the causative agent of malaria, is associated with hemolysis and therefore with release of hemoglobin from RBC. Under inflammatory conditions, cell-free hemoglobin can be oxidized, releasing its heme prosthetic groups and producing deleterious free heme. Here we demonstrate that survival of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seixas E,Gozzelino R,Chora A,Ferreira A,Silva G,Larsen R,Rebelo S,Penido C,Smith NR,Coutinho A,Soares MP

更新日期：2009-09-15 00:00:00

abstract：:Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Abou-Donia MM

更新日期：1975-07-01 00:00:00

abstract：:Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm2 at an overpotential below 300 mV with lon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou H,Yu F,Sun J,He R,Chen S,Chu CW,Ren Z

更新日期：2017-05-30 00:00:00

abstract：:Existing moral psychology research commonly explains certain phenomena in terms of a motivation to blame. However, this motivation is not measured directly, but rather is inferred from other measures, such as participants' judgments of an agent's blameworthiness. The present paper introduces new methods for assessing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ames DL,Fiske ST

更新日期：2015-03-24 00:00:00

abstract：:Entorhinal grid cells integrate sensory and self-motion inputs to provide a spatial metric of a characteristic scale. One function of this metric may be to help localize the firing fields of hippocampal place cells during formation and use of the hippocampal spatial representation ("cognitive map"). Of theoretical imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casali G,Bush D,Jeffery K

更新日期：2019-03-05 00:00:00

abstract：:Two NADPH:cytochrome P450 oxidoreductases (CPRs) from parsley (Petroselinum crispum) were cloned, and the complete proteins were expressed and functionally identified in yeast. The two enzymes, designated CPR1 and CPR2, are 80% identical in amino acid sequence with one another and about 75% identical with CPRs from se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koopmann E,Hahlbrock K

更新日期：1997-12-23 00:00:00

abstract：:The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient remobilization, and developmental transitions. The Arabidopsis type-A response regulators (type-A ARR) are negative regulators of cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheampong AK,Shanks C,Cheng CY,Schaller GE,Dagdas Y,Kieber JJ

更新日期：2020-10-27 00:00:00