Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity.

abstract：:Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells with an activate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molenaar JJ,Ebus ME,Geerts D,Koster J,Lamers F,Valentijn LJ,Westerhout EM,Versteeg R,Caron HN

更新日期：2009-08-04 00:00:00

abstract：:Cell type in Saccharomyces yeasts is regulated by two transposable blocks of DNA, the a and alpha cassettes. There are three loci where either cassette can exist. At the HML and HMR loci the cassettes are not expressed. The cassette at the MAT locus is expressed and controls the cell type. Changes of cell type involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strathern JN,Spatola E,McGill C,Hicks JB

更新日期：1980-05-01 00:00:00

abstract：:The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krummel MF,Mahale JN,Uhl LFK,Hardison EA,Mujal AM,Mazet JM,Weber RJ,Gartner ZJ,Gérard A

更新日期：2018-11-06 00:00:00

abstract：:During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM restores juvenile forms of plasticity, as for instance demonstrated by topographical reconnectivity in sensory pathways. However, to wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Happel MF,Niekisch H,Castiblanco Rivera LL,Ohl FW,Deliano M,Frischknecht R

更新日期：2014-02-18 00:00:00

abstract：:Argonaute (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interference (RNAi) in association with small RNAs. Although overall the mechanism of RNAi is well understood, many molecular details of this complex process are not. Here we report about in-depth steady-state and, in p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deerberg A,Willkomm S,Restle T

更新日期：2013-10-29 00:00:00

abstract：:The production of hybridomas between immunologically activated T cells and malignant T-cell lines offers a potentially unlimited source of soluble T-cell-derived products. Recently, human T-T hybrids have been described; however, their use has been hampered by slow growth and chromosomal instability due at least in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foung SK,Sasaki DT,Grumet FC,Engleman EG

更新日期：1982-12-01 00:00:00

abstract：:Combinations of molecular tags visible in light and electron microscopes become particularly advantageous in the analysis of dynamic cellular components like the Golgi apparatus. This organelle disassembles at the onset of mitosis and, after a sequence of poorly understood events, reassembles after cytokinesis. The pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaietta GM,Giepmans BN,Deerinck TJ,Smith WB,Ngan L,Llopis J,Adams SR,Tsien RY,Ellisman MH

更新日期：2006-11-21 00:00:00

abstract：:Regulation of hexose transport in NIL hamster fibroblasts has been studied in confluent cultures preconditioned for 24 hr in media deprived of glutamine or of serum or of both. Cultures maintained in media containing dialyzed fetal calf serum and 4 mM glutamine accumulated up to 72 nmol of glutamine per mg of cell pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalckar HM,Ullrey DB,Laursen RA

更新日期：1980-10-01 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:Paracoccidioidomycosis, a disease caused by Paracoccidioides brasiliensis, which is endemic to Latin America, is much more common in men than women, suggesting a role for hormonal factors. We recently showed that two other yeasts possess steroid binding proteins and postulated that these receptor-like molecules repres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loose DS,Stover EP,Restrepo A,Stevens DA,Feldman D

更新日期：1983-12-01 00:00:00

abstract：:Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations of essential physiological functions in excitable tissues. Here we describe that superfusion of cultured rat hippocampal neurones w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo LA,Heinemann SH,Terlau H,Ludewig U,Lorra C,Pongs O,Stühmer W

更新日期：1992-03-15 00:00:00

abstract：:Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MS,Chen H,Chen M,Jacques C,Giangrande A,Chien CT

更新日期：2009-04-21 00:00:00

abstract：:Plant viruses are submitted to narrow population bottlenecks both during infection of their hosts and during horizontal transmission between host individuals. The size of bottlenecks exerted on virus populations during plant invasion has been estimated in a few pathosystems but is not addressed yet for horizontal tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moury B,Fabre F,Senoussi R

更新日期：2007-11-06 00:00:00

abstract：:The first step in the formation of the protease resistant form (PrPSc) of prion proteins involves a conformational transition of the monomeric cellular form of PrPC to a more stable aggregation prone state PrPC*. A search of PDBselect and Escherichia coli and yeast genomes shows that the exact pattern of charges in he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dima RI,Thirumalai D

更新日期：2004-10-26 00:00:00

abstract：:Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a role in regulating myelomonocytic differentiation. In this study we examined the effect of expression of MLL-AF9 on differentiation of the monoblastic U937 cell line by using a tetracycline-inducible expression system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caslini C,Shilatifard A,Yang L,Hess JL

更新日期：2000-03-14 00:00:00

abstract：:A three-plasmid system for heterologous expression of 6-deoxyerythronolide B synthase (DEBS) has been developed to facilitate combinatorial biosynthesis of polyketides made by type I modular polyketide synthases (PKSs). The eryA PKS genes encoding the three DEBS subunits were individually cloned into three compatible ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Q,Ashley G,Hutchinson CR,Santi DV

更新日期：1999-10-12 00:00:00

abstract：:The mitogen-activated kinase activating death domain protein (MADD) that is differentially expressed in neoplastic vs. normal cells (DENN) was identified as a substrate for c-Jun N-terminal kinase 3, the first demonstration of such an activity for this stress-activated kinase that is predominantly expressed in the bra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Zhou L,Miller CA

更新日期：1998-03-03 00:00:00

abstract：:A chromosomal locus required for copper resistance and competitive fitness was cloned from a strain of Pseudomonas fluorescens isolated from copper-contaminated agricultural soil. Sequence analysis of this locus revealed six open reading frames with homology to genes involved in cytochrome c biogenesis in other bacter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Azad HR,Cooksey DA

更新日期：1996-07-09 00:00:00

abstract：:Urate oxidase (UOxase; urate:oxygen oxidoreductase, EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but is absent in humans and certain primates. A cDNA clone for UOxase containing an insert of 1.3 kilobases (kb) was isolated from a lambda gt11 cDNA library prepared fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy PG,Nemali MR,Reddy MK,Reddy MN,Yuan PM,Yuen S,Laffler TG,Shiroza T,Kuramitsu HK,Usuda N

更新日期：1988-12-01 00:00:00

abstract：:Mature larvae of Sarcophaga argyrostoma fail to form puparia when kept in contact with water, but pupariate after having been subsequently exposed to dryness for 30 hr. They become increasingly more sensitive to injected ecdysone the longer the exposure to dry conditions. A second wet treatment halts the production of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdarek J,Fraenkel G

更新日期：1970-09-01 00:00:00

abstract：:Following carcinogen exposure in vitro, normal rat tracheal epithelial cells are transformed in a multistage process in which the cultured cells become immortal and, ultimately, neoplastic. Five cell lines derived from tumors produced by neoplastically transformed rat tracheal epithelial cells were examined for the ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker C,Nettesheim P,Barrett JC,Gilmer TM

更新日期：1987-04-01 00:00:00

abstract：:Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace JL,Russell SW,Schreiber RD,Altman A,Katz DH

更新日期：1983-06-01 00:00:00

abstract：:Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasanetz F,Riquelme LA,Della-Maggiore V,O'Donnell P,Murer MG

更新日期：2008-06-10 00:00:00

abstract：:During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Snyder AZ,Vincent JL,Corbetta M,Van Essen DC,Raichle ME

更新日期：2005-07-05 00:00:00

abstract：:We use sequential large-scale crawl data to empirically investigate and validate the dynamics that underlie the evolution of the structure of the web. We find that the overall structure of the web is defined by an intricate interplay between experience or entitlement of the pages (as measured by the number of inbound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong JS,Sarshar N,Roychowdhury VP

更新日期：2008-09-16 00:00:00

abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

更新日期：2003-02-18 00:00:00

abstract：:We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLeod AR,Houlker C,Reinach FC,Smillie LB,Talbot K,Modi G,Walsh FS

更新日期：1985-12-01 00:00:00

abstract：:Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and neurodegenerative disorders. Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA receptor activation to excitotoxic death. NADPH oxidas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lam TI,Brennan-Minnella AM,Won SJ,Shen Y,Hefner C,Shi Y,Sun D,Swanson RA

更新日期：2013-11-12 00:00:00

abstract：:Prions are infectious agents which cause rapidly lethal neurodegenerative diseases in humans and animals following long, clinically silent incubation periods. They are composed of multichain assemblies of misfolded cellular prion protein. While it has long been assumed that prions are themselves neurotoxic, recent dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benilova I,Reilly M,Terry C,Wenborn A,Schmidt C,Marinho AT,Risse E,Al-Doujaily H,Wiggins De Oliveira M,Sandberg MK,Wadsworth JDF,Jat PS,Collinge J

更新日期：2020-09-22 00:00:00

abstract：:Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-L-carnitine (ALCAR). Young (3-5 mo) and old (22-28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen TM,Ingersoll RT,Wehr CM,Lykkesfeldt J,Vinarsky V,Bartholomew JC,Song MH,Ames BN

更新日期：1998-08-04 00:00:00