Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.

abstract：:Observations on the structure and function of the ear in amphisbaenians have been extended to two new species: to Blanus cinereus of the family Amphisbaenidae and Diplometopon zarudnyi of the family Trogonophidae. Blanus, considered one of the most primitive of this group of reptiles, shows a distinctive form of sound...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gans C,Wever EG

更新日期：1975-04-01 00:00:00

abstract：:BDF1 [(C57BL/6 X DBA/2)F1] mice were primed with alum-absorbed ovalbumin, and their spleen cells were cultured with ovalbumin to activate antigen-primed T cells. The activated T cells were then propagated in interleukin 2-containing medium in the presence or absence of affinity-purified glycosylation-inhibiting factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwata M,Ishizaka K

更新日期：1987-04-01 00:00:00

abstract：:Regulatory T cells (Tregs) are key modulators of immune tolerance, capable of suppressing inflammatory immune responses and promoting nonlymphoid tissue homeostasis. Helios, a transcription factor (TF) that is selectively expressed by Tregs, has been shown to be essential for the maintenance of Treg lineage stability ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yates K,Bi K,Haining WN,Cantor H,Kim HJ

更新日期：2018-02-27 00:00:00

abstract：:We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo F,Adhya S

更新日期：2007-03-13 00:00:00

abstract：:We have assessed whether retinoic acid (RA) comes from local sources or is available widely to activate gene expression in embryos. We used an RA-responsive indicator cell line, L-C2A5, to localize RA sources. In these cells, an RA-sensitive promoter/lacZ reporter construct used previously by us to produce indicator t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colbert MC,Linney E,LaMantia AS

更新日期：1993-07-15 00:00:00

abstract：:Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1-Pms1 complex interaction properties of dominant mutant Msh2-Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mutant complexes, the mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess MT,Mendillo ML,Mazur DJ,Kolodner RD

更新日期：2006-01-17 00:00:00

abstract：:DNA fragments encoding the mouse steroid 21-hydroxylase (C21 or Cyp21A1) gene are de novo methylated when introduced into the mouse adrenocortical tumor cell line Y1 by DNA-mediated gene transfer. Although CCGG sequences within the C21 gene are de novo methylated, CCGG sites within flanking vector sequences, other mam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szyf M,Schimmer BP,Seidman JG

更新日期：1989-09-01 00:00:00

abstract：:A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell-cell communication cues, with a focus on enhancing the survival and function of encapsulated pancreatic β-cells to treat type 1 diabetes. When MIN6 cells, a pancreatic β-cell line, were encapsulated in poly(ethylene glycol)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CC,Anseth KS

更新日期：2011-04-19 00:00:00

abstract：:A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown functional significance. Here, we used Caenorhabditis elegans to systematically functionally characterize ASD-associated genes in vivo. Using our custom machine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDiarmid TA,Belmadani M,Liang J,Meili F,Mathews EA,Mullen GP,Hendi A,Wong WR,Rand JB,Mizumoto K,Haas K,Pavlidis P,Rankin CH

更新日期：2020-01-07 00:00:00

abstract：:Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined three crystal structures of the Methanosarcina mazei PylRS complexed with either AMP-PNP, Pyl-AMP plus pyrophosphate, or the Pyl analogue N-epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavran JM,Gundllapalli S,O'Donoghue P,Englert M,Söll D,Steitz TA

更新日期：2007-07-03 00:00:00

abstract：:Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila melanogaster, a complex including the five Male-Specific Lethal (MSL) proteins, "paints" the male X chromosome, med...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larsson J,Chen JD,Rasheva V,Rasmuson-Lestander A,Pirrotta V

更新日期：2001-05-22 00:00:00

abstract：:Ig class-switch recombination (CSR) is directed by the long and repetitive switch regions and requires activation-induced cytidine deaminase (AID). One of the conserved switch-region sequence motifs (AGCT) is a preferred site for AID-mediated DNA-cytosine deamination. By using somatic gene targeting and recombinase-me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han L,Masani S,Yu K

更新日期：2011-07-12 00:00:00

abstract：:A pentapeptide open reading frame equipped with a canonical ribosome-binding site is present in the Escherichia coli 23S rRNA. Overexpression of 23S rRNA fragments containing the mini-gene renders cells resistant to the ribosome-inhibiting antibiotic erythromycin. Mutations that change either the initiator or stop cod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tenson T,DeBlasio A,Mankin A

更新日期：1996-05-28 00:00:00

abstract：:Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedler A,Hansson LO,Veprintsev DB,Freund SM,Rippin TM,Nikolova PV,Proctor MR,Rüdiger S,Fersht AR

更新日期：2002-01-22 00:00:00

abstract：:Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of proinflammatory leuko...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fredman G,Ozcan L,Spolitu S,Hellmann J,Spite M,Backs J,Tabas I

更新日期：2014-10-07 00:00:00

abstract：:The electrical transport through self-assembled monolayers of alkanedithiols was studied in large-area molecular junctions and described by the Simmons model [Simmons JG (1963) J Appl Phys 34:1793-1803 and 2581-2590] for tunneling through a practical barrier, i.e., a rectangular barrier with the image potential includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akkerman HB,Naber RC,Jongbloed B,van Hal PA,Blom PW,de Leeuw DM,de Boer B

更新日期：2007-07-03 00:00:00

abstract：:In this study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in the entire basal ganglia circuitry, as well as other motor-related structures, during the explicit learning of a sequence of finger movements over a month of training. Fourteen right-handed healthy volunteers had ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehéricy S,Benali H,Van de Moortele PF,Pélégrini-Issac M,Waechter T,Ugurbil K,Doyon J

更新日期：2005-08-30 00:00:00

abstract：:This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang ACY,Chang ACH,Kirillova A,Sasagawa K,Su W,Weber G,Lin J,Termglinchan V,Karakikes I,Seeger T,Dainis AM,Hinson JT,Seidman J,Seidman CE,Day JW,Ashley E,Wu JC,Blau HM

更新日期：2018-09-11 00:00:00

abstract：:Poliovirus type 1 cDNA sequences coding for viral capsid polypeptide VP1 were inserted into the beta-lactamase sequence of Escherichia coli plasmid pBR322. Resulting recombinant plasmid pSW119 expressed in Escherichia coli a VP1-beta-lactamase fusion protein that reacted with antibodies raised against poliovirus capsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Werf S,Wychowski C,Bruneau P,Blondel B,Crainic R,Horodniceanu F,Girard M

更新日期：1983-08-01 00:00:00

abstract：:The coupling of calcium transport to ATP hydrolysis in rabbit muscle sarcoplasmic reticulum vesicles was determined under steady-state conditions in the presence of 5 mM oxalate and using various concentrations of vesicles to modulate the concentration of free Ca2+ in the medium. This experimental approach takes advan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gafni A,Boyer PD

更新日期：1985-01-01 00:00:00

abstract：:Retrotransposons and retroviruses integrate nonrandomly into eukaryotic genomes. For the yeast retrotransposon Ty5, integration preferentially occurs within domains of heterochromatin. Targeting to these locations is determined by interactions between an amino acid sequence motif at the C terminus of Ty5 integrase (IN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Dai J,Fuerst PG,Voytas DF

更新日期：2003-05-13 00:00:00

abstract：:This study challenges the paradigm that salt marsh plants prevent lateral wave-induced erosion along wetland edges by binding soil with live roots and clarifies the role of vegetation in protecting the coast. In both laboratory flume studies and controlled field experiments, we show that common salt marsh plants do no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feagin RA,Lozada-Bernard SM,Ravens TM,Möller I,Yeager KM,Baird AH

更新日期：2009-06-23 00:00:00

abstract：:S-nitrosation is a posttranslational, oxidative addition of NO to cysteine residues of proteins that has been proposed as a cGMP-independent signaling pathway [Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Nat Rev Mol Cell Biol 6:150-166]. A paradox of S-nitrosation is that only a small set of reactive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell DA,Morton SU,Fernhoff NB,Marletta MA

更新日期：2007-07-10 00:00:00

abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh H,Medina KL,Pongubala JM

更新日期：2005-04-05 00:00:00

abstract：:The current study details efficient lesion-free cutaneous vaccination via vaccine delivery into an array of micropores in the skin, instead of bolus injection at a single site. Such delivery effectively segregated vaccine-induced inflammation, resulting in rapid resolution of the inflammation, provided that distances ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Li B,Wu MX

更新日期：2015-04-21 00:00:00

abstract：:Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam S,Buettner R,Turkson J,Kim D,Cheng JQ,Muehlbeyer S,Hippe F,Vatter S,Merz KH,Eisenbrand G,Jove R

更新日期：2005-04-26 00:00:00

abstract：:Swarming and mass migration are spectacular and sometimes devastating features of the biology of various animal species. These phenomena are typically associated with actual or anticipated depletion of food resources after an increase in population density, but the mechanisms driving such collective movements are poor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simpson SJ,Sword GA,Lorch PD,Couzin ID

更新日期：2006-03-14 00:00:00

abstract：:Human rhinovirus (HRV) and other members of the enterovirus genus bind small-molecule antiviral compounds in a cavity buried within the viral capsid protein VP1. These compounds block the release of the viral protein VP4 and RNA from inside the capsid during the uncoating process. In addition, the antiviral compounds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy A,Post CB

更新日期：2012-04-03 00:00:00

abstract：:To investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson JM,Spencer JA,Riggs AD,Graves JA

更新日期：1991-12-15 00:00:00

abstract：:Ca(V)1 channels initiate excitation-contraction coupling in skeletal and cardiac muscle. During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the β-adrenergic receptor/cAMP-dependent protein k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emrick MA,Sadilek M,Konoki K,Catterall WA

更新日期：2010-10-26 00:00:00