Abstract:
:Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of such spiraling remains to be identified. Here, we examined whether plateau depolarizations (UP states) in striatal neurons relate better to active epochs in local field potentials recorded from closely related cortical areas than to those recorded in less-related cortical areas. Our results show that, in anesthetized rats, the coordination between cortical areas and striatal regions obeys a mediolateral gradient and keeps track of slow wave trajectory across the neocortex. Moreover, activity in one cortical area induced phase advances in UP state onset and phase delays in UP state termination in nonmatching striatal regions, reflecting the existence of functional connections that could encode large-scale interactions between corticostriatal channels as subthreshold influences on striatal projection neurons.
journal_name
Proc Natl Acad Sci U S Aauthors
Kasanetz F,Riquelme LA,Della-Maggiore V,O'Donnell P,Murer MGdoi
10.1073/pnas.0711113105subject
Has Abstractpub_date
2008-06-10 00:00:00pages
8124-9issue
23eissn
0027-8424issn
1091-6490pii
0711113105journal_volume
105pub_type
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