POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation.

abstract：:Saccharomyces cerevisiae possesses a high-affinity estrogen binding protein and an endogenous ligand that displaces [3H]estradiol from both the yeast binding protein and mammalian estrogen receptors. Semipurified preparations of this ligand have been shown to exhibit estrogenic activity in mammalian systems. We now de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman D,Tökés LG,Stathis PA,Miller SC,Kurz W,Harvey D

更新日期：1984-08-01 00:00:00

abstract：:Methane emissions due to accidents in the oil and natural gas sector are very challenging to monitor, and hence are seldom considered in emission inventories and reporting. One of the main reasons is the lack of measurements during such events. Here we report the detection of large methane emissions from a gas well bl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandey S,Gautam R,Houweling S,Denier van der Gon H,Sadavarte P,Borsdorff T,Hasekamp O,Landgraf J,Tol P,van Kempen T,Hoogeveen R,van Hees R,Hamburg SP,Maasakkers JD,Aben I

更新日期：2019-12-16 00:00:00

abstract：:Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker encodes a homologue of the moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to a serine protease-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimopoulos G,Richman A,Müller HM,Kafatos FC

更新日期：1997-10-14 00:00:00

abstract：:Colloquium talks at prestigious universities both create and reflect academic researchers' reputations. Gender disparities in colloquium talks can arise through a variety of mechanisms. The current study examines gender differences in colloquium speakers at 50 prestigious US colleges and universities in 2013-2014. Usi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nittrouer CL,Hebl MR,Ashburn-Nardo L,Trump-Steele RCE,Lane DM,Valian V

更新日期：2018-01-02 00:00:00

abstract：:The dynamics of excited-state double proton transfer of model DNA base pairs, 7-azaindole dimers, is reported using femtosecond fluorescence spectroscopy. To elucidate the nature of the transfer in the condensed phase, here we examine variation of solvent polarity and viscosity, solute concentration, and isotopic frac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OH,Zewail AH

更新日期：2007-05-22 00:00:00

abstract：:Optimization theory has been used to analyze evolutionary adaptation. This theory has explained many features of biological systems, from the genetic code to animal behavior. However, these systems show important deviations from optimality. Typically, these deviations are large in some particular components of the sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Escudero A,Rivera-Alba M,de Polavieja GG

更新日期：2009-12-01 00:00:00

abstract：:A discrepancy of about 20% exists between the molecular weight of the alpha subunit of Torpedo californica electroplax acetylcholine receptor as determined by gel electrophoresis of the mature protein (Mr 40,000 +/- 2000) and by nucleotide sequence analysis of cDNA (Mr approximately equal to 50,000). We demonstrate by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conti-Tronconi BM,Hunkapiller MW,Raftery MA

更新日期：1984-05-01 00:00:00

abstract：:Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation patterns across a large number of spatially distributed regions. Functional magnetic resonance imaging (fMRI) has played a central role in demonstrating the nontrivial spatial and topologica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalesky A,Fornito A,Cocchi L,Gollo LL,Breakspear M

更新日期：2014-07-15 00:00:00

abstract：:An experimental study of the configurational thermodynamics for a series of near-eutectic Pt80-x Cu x P20 bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Na JH,Corona SL,Hoff A,Johnson WL

更新日期：2020-02-11 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or RAM2, abolish the farnesyltransferase activity responsible for prenylation of Ras proteins and the a-factor mating pheromone. Here we report that the function of RAM1 and RAM2 genes is required for the membrane localization of Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He B,Chen P,Chen SY,Vancura KL,Michaelis S,Powers S

更新日期：1991-12-15 00:00:00

abstract：:Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SN,Larsson O,Bränström R,Bertorello AM,Leibiger B,Leibiger IB,Moede T,Köhler M,Meister B,Berggren PO

更新日期：1999-08-31 00:00:00

abstract：:At each stage of infection, the major coat protein of coliphage M13 binds to the E. coli cytoplasmic membrane with its antigenic site exposed to the cell exterior [Wickner, W. (1975) Proc. Nat. Acad. Sci. USA 72, 4749-4753]. This antigenic site is now shown to be at the amino-terminus of the protein. The amino-terminu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner W

更新日期：1976-04-01 00:00:00

abstract：:An essential step in the pathogenesis of human papillomavirus (HPV)-associated cancers is the dysregulated expression of the viral oncogenes. The papillomavirus E2 protein can silence the long control region (LCR) promoter that controls viral E6 and E7 oncogene expression. The mechanisms by which E2 represses oncogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JA,White EA,Sowa ME,Powell ML,Ottinger M,Harper JW,Howley PM

更新日期：2010-02-23 00:00:00

abstract：:The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manella G,Aviram R,Bolshette N,Muvkadi S,Golik M,Smith DF,Asher G

更新日期：2020-01-07 00:00:00

abstract：:A recently discovered family of natural anion channelrhodopsins (ACRs) have the highest conductance among channelrhodopsins and exhibit exclusive anion selectivity, which make them efficient inhibitory tools for optogenetics. We report analysis of flash-induced absorption changes in purified wild-type and mutant ACRs,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sineshchekov OA,Li H,Govorunova EG,Spudich JL

更新日期：2016-04-05 00:00:00

abstract：:Treatment of myoblast cell lines with 3-deazaadenosine stimulates differentiation into myofibers. Myoblast clone L5/ 3B5 , which does not form myofibers after 6 days in fusion medium, was stimulated to form myofibers after 5 days of culture in fusion medium containing 50 microM 3-deazaadenosine. Myoblast clone L5/ 3C4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scarpa S,Strom R,Bozzi A,Aksamit RR,Backlund PS Jr,Chen J,Cantoni GL

更新日期：1984-05-01 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:The origin-binding protein (OBP) from herpes simplex virus 1 is a member of the SF2 helicase superfamily and is required for the initiation of DNA synthesis from a viral origin of DNA replication (oriS). The high-affinity binding sites for OBP in oriS, boxes I and II, are separated by an A+T-rich spacer. We used the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafsson CM,Hammarsten O,Falkenberg M,Elias P

更新日期：1994-05-24 00:00:00

abstract：:Poliovirus RNA polymerase requires a host factor to initiate RNA synthesis in vitro. The host factor was previously purified to near homogeneity from HeLa cells but was not assigned an enzymatic activity. This report describes the purification of a terminal uridylyltransferase that can act as host factor. By all crite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrews NC,Baltimore D

更新日期：1986-01-01 00:00:00

abstract：:A mammalian A-type cyclin, cyclin A1, is highly expressed in testes of both human and mouse and targeted mutagenesis in the mouse has revealed the unique requirement for cyclin A1 in the progression of male germ cells through the meiotic cell cycle. While very low levels of cyclin A1 have been reported in the human he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao C,Wang XY,Wei HQ,Li SQ,Merghoub T,Pandolfi PP,Wolgemuth DJ

更新日期：2001-06-05 00:00:00

abstract：:Plants adapt to alterations in light conditions by controlling their gene expression profiles. Expression of light-inducible genes is transcriptionally induced by transcription factors such as HY5. However, few detailed analyses have been carried out on the control of transcription start sites (TSSs). Of the various w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurihara Y,Makita Y,Kawashima M,Fujita T,Iwasaki S,Matsui M

更新日期：2018-07-24 00:00:00

abstract：:The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo CC,Sturm VE,Zhou J,Gennatas ED,Trujillo AJ,Hua AY,Crawford R,Stables L,Kramer JH,Rankin K,Levenson RW,Rosen HJ,Miller BL,Seeley WW

更新日期：2016-04-26 00:00:00

abstract：:Early members of the dinosaur-pterosaur clade Ornithodira are very rare in the fossil record, obscuring our understanding of the origins of this important group. Here, we describe an early ornithodiran (Kongonaphon kely gen. et sp. nov.) from the Mid-to-Upper Triassic of Madagascar that represents one of the smallest ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kammerer CF,Nesbitt SJ,Flynn JJ,Ranivoharimanana L,Wyss AR

更新日期：2020-07-28 00:00:00

abstract：:Adult stem cells represent unique populations of undifferentiated cells with self-renewal capacity. In many tissues, stem cells divide less often than their progeny. It has been widely speculated, but largely untested, that their undifferentiated and quiescent state may make stem cells more efficient as donors for clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Greco V,Guasch G,Fuchs E,Mombaerts P

更新日期：2007-02-20 00:00:00

abstract：:The subdivision of all the experimental days of the Whitetop project into two approximately equal groups, group W with predominantly westerly winds aloft and group E with frequent easterly winds, shows a remarkable difference in the apparent effect of seeding. On W days there was no detectable effect of seeding on rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovasich JL,Neyman J,Scott EL,Smith JA

更新日期：1969-11-01 00:00:00

abstract：:Rapid electrical conduction in the His-Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light on the regulation of early specification and morphogenesis of the His-Purkinje system, less is known about how transcriptional regulation establishes impulse con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang SS,Kim KH,Rosen A,Smyth JW,Sakuma R,Delgado-Olguín P,Davis M,Chi NC,Puviindran V,Gaborit N,Sukonnik T,Wylie JN,Brand-Arzamendi K,Farman GP,Kim J,Rose RA,Marsden PA,Zhu Y,Zhou YQ,Miquerol L,Henkelman RM,Sta

更新日期：2011-08-16 00:00:00

abstract：:Photosystem II (PSII) is an intrinsic membrane protein complex that functions as a light-driven water:plastoquinone oxidoreductase in oxygenic photosynthesis. Electron transport in PSII is associated with formation of reactive oxygen species (ROS) responsible for oxidative modifications of PSII proteins. In this study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Prasad A,Sedlářová M,Kale R,Frankel LK,Sallans L,Bricker TM,Pospíšil P

更新日期：2021-01-26 00:00:00

abstract：:Death of pancreatic β cells is a pathological hallmark of type 1 diabetes (T1D). However, the molecular mechanisms of β cell death and its regulation are poorly understood. Here we describe a unique regulatory pathway of β cell death that comprises microRNA-21, its target tumor suppressor PDCD4, and its upstream trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan Q,Wang T,Kameswaran V,Wei Q,Johnson DS,Matschinsky F,Shi W,Chen YH

更新日期：2011-07-19 00:00:00

abstract：:Inhibin, a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion, has recently been purified. The major form of this protein is an alpha beta heterodimer encoded by two separate genes. In contrast to the FSH-suppressing action of the alpha beta heterodimer, the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsueh AJ,Dahl KD,Vaughan J,Tucker E,Rivier J,Bardin CW,Vale W

更新日期：1987-07-01 00:00:00

abstract：:Adrenocorticotropic hormone (ACTH) inhibited [3H]thymidine incorporation in normal adrenocortical cells of adult rats in culture, with a concomitant increase in corticosterone production and a characteristic retraction of cells. Both dibutyryl cyclic AMP and an analog of ACTH, which produces virtually no cyclic AMP, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandran J,Suyama AT

更新日期：1975-01-01 00:00:00