Photochemical reaction cycle transitions during anion channelrhodopsin gating.

abstract：:Simulations with a regional chemical transport model show that anthropogenic emissions of volatile organic compounds and nitrogen oxides (NO(x) = NO + NO(2)) lead to a dramatic diurnal variation of surface ozone (O(3)) in Houston, Texas. During the daytime, photochemical oxidation of volatile organic compounds catalyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Lei W,Tie X,Hess P

更新日期：2004-04-27 00:00:00

abstract：:The effects of three anti-inflammatory drugs, which interfere with arachidonic acid transformation by three different enzymes, have been compared by using a simple model of tissue damage and foreign body rejection. In groups of control rats, subcutaneously implanted polyester sponges were rejected after a mean of 12 d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgs GA,Mugridge KG,Moncada S,Vane JR

更新日期：1984-05-01 00:00:00

abstract：:The low-energy conformations for a series of peptides based on the sequence of the ras P21 protein from position 55 to position 67 have been computed using conformational energy analysis. These sequences differed at position 61 and contained Gln, Pro, Leu, Lys, and Arg at this position. P21 proteins with Gln, Glu, or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Brandt-Rauf PW,Carty RP,Lubowsky J,Avitable M,Gibson KD,Scheraga HA

更新日期：1987-12-01 00:00:00

abstract：:α-SNAP [soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein] and NSF proteins are conserved across eukaryotes and sustain cellular vesicle trafficking by mediating disassembly and reuse of SNARE protein complexes, which facilitate fusion of vesicles to target membranes. However, certain haplotypes of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bayless AM,Smith JM,Song J,McMinn PH,Teillet A,August BK,Bent AF

更新日期：2016-11-22 00:00:00

abstract：:A comparison of the monoclinic and orthorhombic crystal structures of the uncomplexed double-stranded, antiparallel, left-handed beta-helix (5.6 amino acid residues per turn) (increases decreases beta 5.6) conformers of gramicidin A reveals marked differences in the tryptophan side-chain orientations and the degree of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langs DA,Smith GD,Courseille C,Précigoux G,Hospital M

更新日期：1991-06-15 00:00:00

abstract：:We lack a clear understanding of the enzootic maintenance of the bacterium (Yersinia pestis) that causes plague and the sporadic epizootics that occur in its natural rodent hosts. A key to elucidating these epidemiological dynamics is determining the dominant transmission routes of plague. Plague can be acquired from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webb CT,Brooks CP,Gage KL,Antolin MF

更新日期：2006-04-18 00:00:00

abstract：:A protein of 87 kilodaltons (87 kDa) was previously identified as a major specific substrate for protein kinase C in neuronal and other tissues. We have now studied the effect of protein kinase C-catalyzed phosphorylation of this protein on its association with membranes in isolated nerve terminals (synaptosomes) from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JK,Walaas SI,Sihra TS,Aderem A,Greengard P

更新日期：1989-04-01 00:00:00

abstract：:Alcohol exposure during development can cause brain malformations and neurobehavioral abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could counteract the neurotoxic effects of alcohol deserves high priority. Here, we report that pituitary adenylate cyclase-activating polypept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaudry D,Rousselle C,Basille M,Falluel-Morel A,Pamantung TF,Fontaine M,Fournier A,Vaudry H,Gonzalez BJ

更新日期：2002-04-30 00:00:00

abstract：:Previous studies have identified human breast tumor particles possessing many of the features characteristic of RNA tumor viruses. In addition to the expected size (600 S) and density (1.16 g/ml) these include possession of an outer membrane and an inner one surrounding a "core" containing a DNA polymerase and a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Sweet RW,Dejak D,Spiegelman S

更新日期：1977-02-01 00:00:00

abstract：:Osmotically shocked Escherichia coli and membrane vesicle ghosts from E. coli cells have lost the ability to accumulate potassium by active transport. The addition of valinomycin to the membrane ghosts restores the capacity to accumulate radioactive (42)K and (86)Rb by a temperature- and energy-dependent process. Memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharyya P,Epstein W,Silver S

更新日期：1971-07-01 00:00:00

abstract：:Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF(-/-)) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bel S,Elkis Y,Elifantz H,Koren O,Ben-Hamo R,Lerer-Goldshtein T,Rahimi R,Ben Horin S,Nyska A,Shpungin S,Nir U

更新日期：2014-04-01 00:00:00

abstract：:A culture of mouse A9 cells yielded clones of both high and low malignancy. Confirmation of the differences in malignancy of the clones was obtained after their hybridization with subclones of YACIR a lymphoma induced by Moloney leukemia virus. Low malignant A9 clones suppressed the malignancy of the YACIR partner in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clements GB,Fenyö EM,Klein G

更新日期：1976-06-01 00:00:00

abstract：:In this paper we report a time-course study of development of experimental allergic encephalomyelitis in Lewis rats, by monitoring neuroendocrine regulation of the hypothalamus-pituitary-adrenal axis through corticotropin-releasing hormone mRNA expression, inflammatory cellular infiltrate, macrophagic and neuronal nit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calzà L,Giardino L,Pozza M,Micera A,Aloe L

更新日期：1997-04-01 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:Current knowledge of the evolution of the postcranial skeleton in the genus Homo is hampered by a geographically and chronologically scattered fossil record. Here we present a complete characterization of the postcranium of the middle Pleistocene paleodeme from the Sima de los Huesos (SH) and its paleobiological impli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL,Carretero JM,Lorenzo C,Gómez-Olivencia A,Pablos A,Rodríguez L,García-González R,Bonmatí A,Quam RM,Pantoja-Pérez A,Martínez I,Aranburu A,Gracia-Téllez A,Poza-Rey E,Sala N,García N,Alcázar de Velasco A,Cuenca-B

更新日期：2015-09-15 00:00:00

abstract：:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efendić S,Wajngot A,Cerasi E,Luft R

更新日期：1980-12-01 00:00:00

abstract：:The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman NB,Fritz T,Nimpf S,Pichler P,Lauwers M,Hickman RW,Papadaki-Anastasopoulou A,Ushakova L,Heuser T,Resch GP,Saunders M,Shaw JA,Keays DA

更新日期：2015-01-06 00:00:00

abstract：:Quantifying the uncertainty for the present climate and the predictions of climate change in the suite of imperfect Atmosphere Ocean Science (AOS) computer models is a central issue in climate change science. Here, a systematic approach to these issues with firm mathematical underpinning is developed through empirical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ,Gershgorin B

更新日期：2010-08-24 00:00:00

abstract：:The complete coding region of maize transposable element Ac and truncated but active derivatives of it were placed under the control of promoters of different strength and tested for the ability to excise transposable element Ds from a beta-glucuronidase reporter gene in a cotransfection assay in Petunia protoplasts. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker D,Lütticke R,Li M,Starlinger P

更新日期：1992-06-15 00:00:00

abstract：:Development of in vitro resistance to HN2 (also called mustargen or mechlorethamine hydrochloride), N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), and cisplatin [cis-diamminedichloroplatinum(II)] was achieved in two human cell lines, the Raji/Burkitt lymphoma and a squamous cell carcinoma of the tongue. A 10- to 20-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei E 3rd,Cucchi CA,Rosowsky A,Tantravahi R,Bernal S,Ervin TJ,Ruprecht RM,Haseltine WA

更新日期：1985-04-01 00:00:00

abstract：:Better understanding myelination of peripheral nerves would benefit patients affected by peripheral neuropathies, including Charcot-Marie-Tooth disease. Little is known about the role the Golgi compartment plays in Schwann cell (SC) functions. Here, we studied the role of Golgi in myelination of peripheral nerves in m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba T,Alvarez-Prats A,Kim YJ,Abebe D,Wilson S,Aldworth Z,Stopfer MA,Heuser J,Balla T

更新日期：2020-11-10 00:00:00

abstract：:The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangione PP,Porcari R,Gillmore JD,Pucci P,Monti M,Porcari M,Giorgetti S,Marchese L,Raimondi S,Serpell LC,Chen W,Relini A,Marcoux J,Clatworthy IR,Taylor GW,Tennent GA,Robinson CV,Hawkins PN,Stoppini M,Wood SP,Pepys

更新日期：2014-01-28 00:00:00

abstract：:Early events in the action of 17-beta-estradiol can be studied in soluble extracts of rat uterus by exposure of the estradiol-receptor protein to a DNA-cellulose matrix. After complexing with [(3)H]estradiol, the 4S receptor protein binds to the DNA, and it can be eluted with buffer of high ionic strength as a more ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto KR,Alberts BM

更新日期：1972-08-01 00:00:00

abstract：:The method of evolutionary stable strategies (ESS), in its current form, is confronted with a difficulty when it tries to explain how some social behaviors initiate their evolution. We show that this difficulty may be removed by changing the assumption made tacitly in game theory (and in ESS) of randomness of meetings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eshel I,Cavalli-Sforza LL

更新日期：1982-02-01 00:00:00

abstract：:Optical spectra of biological polymers contain important information about their structure and function in living organisms. This information can be accessed by extracting an optical interaction of monomers, i.e., their exciton coupling, from experimental data. This coupling is sensitive to molecular structure, geomet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burin AL,Armbruster ME,Hariharan M,Lewis FD

更新日期：2009-01-27 00:00:00

abstract：:Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medeiros LP,Garcia G,Thompson JN,Guimarães PR Jr

更新日期：2018-11-20 00:00:00

abstract：:The formation of heparan sulfate occurs within the lumen of the endoplasmic reticulum-Golgi complex-trans-Golgi network by the concerted action of several glycosyltransferases, an epimerase, and multiple sulfotransferases. In this report, we have examined the location and interaction of tagged forms of five of the bio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinhal MA,Smith B,Olson S,Aikawa J,Kimata K,Esko JD

更新日期：2001-11-06 00:00:00

abstract：:In adipocytes, adenylate cyclase is positively regulated by beta-adrenergic agents and negatively regulated by adenosine. Incubation of adipocytes with adenosine deaminase relieves the inhibition of adenylate cyclase by destroying the adenosine that the cells release into the medium. When adipocytes are incubated with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung FZ,Weber HW,Appleman MM

更新日期：1985-03-01 00:00:00

abstract：:We analyzed variability in outer surface protein B (OspB) from Borrelia burgdorferi (Bb), the causative agent of Lyme disease, to determine how Bb escapes immune destruction. We have shown that vaccination with OspB from Bb strain B31 protected mice from infection with Bb B31 but not against Bb N40. The present study ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fikrig E,Tao H,Kantor FS,Barthold SW,Flavell RA

更新日期：1993-05-01 00:00:00

abstract：:Glands of the uterus are essential for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands of the uterus and a critical regulator of glandular epithelium (GE) differentiation, development, and function. Mice with a conditional deletion of FOXA2 in the adult uterus, created using th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhakal P,Kelleher AM,Behura SK,Spencer TE

更新日期：2020-09-22 00:00:00