Insulin release, insulin sensitivity, and glucose intolerance.

Abstract:

:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and intravenous glucose administration. The body weights, ages, and sexes of the subjects were well matched with those of control subjects with normal tolerances to oral and intravenous glucose administration. Computer analysis of the glucose and insulin curves during a standardized glucose infusion test made possible the measurement of the initiatory (parameters KI and IP) and potentiatory (parameter KP) effects of glucose on insulin release and of the sensitivity to endogenous insulin (parameter KG). In subjects with impaired oral but normal intravenous glucose tolerance tests, KG was decreased, KP was increased, and KI and IP were normal. However, in these subjects, KI and IP were considerably lower than in a matched group of control subjects with the same decrease in KG but with normal oral and intravenous glucose tolerance tets. In subjects in which both oral and intravenous glucose tolerance tests were impaired and in subjects with mild manifest diabetes, KI, IP, and KG were decreased whereas KP was normal. These data suggest that all stages of glucose intolerance are accompanied by a decreased ability of glucose to initiate insulin release and by decreased sensitivity to insulin. These derangements seem to be partially compensated for by enhancement of the capacity of glucose to potentiate insulin release in subjects with decreased oral but normal intravenous glucose tolerance tests.

authors

Efendić S,Wajngot A,Cerasi E,Luft R

doi

10.1073/pnas.77.12.7425

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

7425-9

issue

12

eissn

0027-8424

issn

1091-6490

journal_volume

77

pub_type

杂志文章
  • Ethylene can stimulate Arabidopsis hypocotyl elongation in the light.

    abstract::Ethylene inhibits hypocotyl elongation in etiolated Arabidopsis seedlings. However, when Arabidopsis was grown in the light in the presence of ethylene or its precursor 1-aminocyclopropane-1-carboxylic acid (ACC), a marked induction of hypocotyl elongation occurred. This resulted from an increase in cell expansion rat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.6.2756

    authors: Smalle J,Haegman M,Kurepa J,Van Montagu M,Straeten DV

    更新日期:1997-03-18 00:00:00

  • The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.

    abstract::Lactobacillus johnsonii NCC 533 is a member of the acidophilus group of intestinal lactobacilli that has been extensively studied for their "probiotic" activities that include, pathogen inhibition, epithelial cell attachment, and immunomodulation. To gain insight into its physiology and identify genes potentially invo...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0307327101

    authors: Pridmore RD,Berger B,Desiere F,Vilanova D,Barretto C,Pittet AC,Zwahlen MC,Rouvet M,Altermann E,Barrangou R,Mollet B,Mercenier A,Klaenhammer T,Arigoni F,Schell MA

    更新日期:2004-02-24 00:00:00

  • Ultrashort antibacterial and antifungal lipopeptides.

    abstract::Host-defense cationic antimicrobial peptides ( approximately 12-50 aa long) play an essential protective role in the innate immune system of all organisms. Lipopeptides, however, are produced only in bacteria and fungi during cultivation, and they are composed of specific lipophilic moieties attached to anionic peptid...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0606129103

    authors: Makovitzki A,Avrahami D,Shai Y

    更新日期:2006-10-24 00:00:00

  • Fluctuations uncover a distinct class of traveling waves.

    abstract::Epidemics, flame propagation, and cardiac rhythms are classic examples of reaction-diffusion waves that describe a switch from one alternative state to another. Only two types of waves are known: pulled, driven by the leading edge, and pushed, driven by the bulk of the wave. Here, we report a distinct class of semipus...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1715737115

    authors: Birzu G,Hallatschek O,Korolev KS

    更新日期:2018-04-17 00:00:00

  • Ligand-directed retroviral targeting of human breast cancer cells.

    abstract::We explored the feasibility of designing retroviral vectors that can target human breast cancer cells with characteristic receptors via ligand-receptor interaction. The ecotropic Moloney murine leukemia virus envelope was modified by insertion of sequences encoding human heregulin. Ecotropic virus, which normally does...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.21.9747

    authors: Han X,Kasahara N,Kan YW

    更新日期:1995-10-10 00:00:00

  • Protective effect of immunization with nonviral antigens against Friend leukemia virus in mice.

    abstract::DBA/2 mice immunized with poly(A).poly(U) complexed with methylated bovine serum albumin and emulsified in Freund's complete adjuvant were protected against challenge with Friend leukemia virus. There was no correlation between the level of antibody to the immunogen in the prechallenge serum and induced resistance to ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.4.2018

    authors: Nahon-Merlin E,Lacour F,Friend C,Revoltella R

    更新日期:1979-04-01 00:00:00

  • Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: an MRI study.

    abstract::The drought of progress in clinical brain tumor therapy provides an impetus for developing new treatments as well as methods for testing therapeutics in animal models. The inability of traditional assays to simultaneously measure tumor size, location, growth kinetics, and cell kill achieved by a treatment complicates ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.12.7012

    authors: Ross BD,Zhao YJ,Neal ER,Stegman LD,Ercolani M,Ben-Yoseph O,Chenevert TL

    更新日期:1998-06-09 00:00:00

  • Three-body interactions improve the prediction of rate and mechanism in protein folding models.

    abstract::Here we study the effects of many-body interactions on rate and mechanism in protein folding by using the results of molecular dynamics simulations on numerous coarse-grained Calpha-model single-domain proteins. After adding three-body interactions explicitly as a perturbation to a Gō-like Hamiltonian with native pair...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0403486101

    authors: Ejtehadi MR,Avall SP,Plotkin SS

    更新日期:2004-10-19 00:00:00

  • Genomic linkage of male song and female acoustic preference QTL underlying a rapid species radiation.

    abstract::The genetic coupling hypothesis of signal-preference evolution, whereby the same genes control male signal and female preference for that signal, was first inspired by the evolution of cricket acoustic communication nearly 50 years ago. To examine this hypothesis, we compared the genomic location of quantitative trait...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0900229106

    authors: Shaw KL,Lesnick SC

    更新日期:2009-06-16 00:00:00

  • Excitation transfer spectroscopy with two metastable 138Ba+ ions in same trap.

    abstract::In the absence of lasers approaching trapped ion clock transitions in sharpness we propose to replace the 12.49 m laser field exciting the D3/2-D5/2 transition of the single Ba+ ion A in D3/2 with the near-field of a close by identical ion B in the excited D5/2 state. We tune the frequency of the near-field by the dif...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.14.6861

    authors: Dehmelt H,Zhao X,Yu N,Nagourney W

    更新日期:1996-07-09 00:00:00

  • Effect of phenotypic variation on kin selection.

    abstract::An expression for the equilibrium of the mean phenotypic value of a quantitative character is derived for a model in which the fitness of an individual depends on its own phenotype and the mean phenotypic value of a group of related individuals. When selection is weak the equilibrium mean is well predicted by Hamilton...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.12.7506

    authors: Boyd R,Richerson PJ

    更新日期:1980-12-01 00:00:00

  • Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.

    abstract::Understanding differences in DNA double-strand break (DSB) repair between tumor and normal tissues would provide a rationale for developing DNA repair-targeted cancer therapy. Here, using knock-in mouse models for measuring the efficiency of two DSB repair pathways, homologous recombination (HR) and nonhomologous end-...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2002917117

    authors: Wang C,Tang H,Geng A,Dai B,Zhang H,Sun X,Chen Y,Qiao Z,Zhu H,Yang J,Chen J,He Q,Qin N,Xie J,Tan R,Wan X,Gao S,Jiang Y,Sun FL,Mao Z

    更新日期:2020-10-20 00:00:00

  • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells.

    abstract::Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety, in vivo persistence, and ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 临床试验,杂志文章

    doi:10.1073/pnas.242600099

    authors: Yee C,Thompson JA,Byrd D,Riddell SR,Roche P,Celis E,Greenberg PD

    更新日期:2002-12-10 00:00:00

  • An exon that prevents transport of a mature mRNA.

    abstract::In Caenorhabditis elegans, pre-mRNA for the essential splicing factor U2AF65 sometimes is spliced to produce an RNA that includes an extra 216-bp internal exon, exon 3. Inclusion of exon 3 inserts an in-frame stop codon, yet this RNA is not subject to SMG-mediated RNA surveillance. To test whether exon 3 causes RNA to...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.7.3813

    authors: MacMorris MA,Zorio DA,Blumenthal T

    更新日期:1999-03-30 00:00:00

  • Anti-peripheral myelin antibody in patients with demyelinating neuropathy: quantitative and kinetic determination of serum antibody by complement component 1 fixation.

    abstract::The role of anti-peripheral nerve myelin antibody (anti-PNM Ab) in the pathogenesis of acquired demyelination of peripheral nerve is unclear, in part, due to the poor correlation between antibody and disease activity. Previous studies show that only 27-50% of patients with acute demyelinating neuropathy or Guillain-Ba...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.82.3.905

    authors: Koski CL,Humphrey R,Shin ML

    更新日期:1985-02-01 00:00:00

  • A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.

    abstract::Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding pr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.241629998

    authors: Friedler A,Hansson LO,Veprintsev DB,Freund SM,Rippin TM,Nikolova PV,Proctor MR,Rüdiger S,Fersht AR

    更新日期:2002-01-22 00:00:00

  • DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination.

    abstract::Proceedings of the National Academy of Sciences Colloquium on the roles of homologous recombination in DNA replication are summarized. Current findings in experimental systems ranging from bacteriophages to mammalian cell lines substantiate the idea that homologous recombination is a system supporting DNA replication ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.151260698

    authors: Kuzminov A

    更新日期:2001-07-17 00:00:00

  • Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression.

    abstract::The human placental alkaline phosphatase gene has been cloned and reintroduced into mammalian cells. When a plasmid carrying the gene under control of the simian virus 40 early promoter (pSV2Apap) is transfected into a variety of different cell types, placental alkaline phosphatase activity can readily be detected by ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.17.6342

    authors: Henthorn P,Zervos P,Raducha M,Harris H,Kadesch T

    更新日期:1988-09-01 00:00:00

  • Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum.

    abstract::One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorly documented. An important aspect of ER translational control is the mol...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1901742116

    authors: Ueno T,Taga Y,Yoshimoto R,Mayeda A,Hattori S,Ogawa-Goto K

    更新日期:2019-05-07 00:00:00

  • Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.

    abstract::Influenza hemagglutinin (HA) is the primary target of the humoral response during infection/vaccination. Current influenza vaccines typically fail to elicit/boost broadly neutralizing antibodies (bnAbs), thereby limiting their efficacy. Although several bnAbs bind to the conserved stem domain of HA, focusing the immun...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1402766111

    authors: Mallajosyula VV,Citron M,Ferrara F,Lu X,Callahan C,Heidecker GJ,Sarma SP,Flynn JA,Temperton NJ,Liang X,Varadarajan R

    更新日期:2014-06-24 00:00:00

  • Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

    abstract::Type beta transforming growth factor (TGF-beta) activity was found in conditioned medium harvested from fetal rat and neonatal mouse calvariae by using the anchorage-independent growth of normal rat kidney fibroblasts as an indicator system. Calvariae incubated with parathyroid hormone, 1,25-dihydroxyvitamin D3, and i...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.7.2024

    authors: Pfeilschifter J,Mundy GR

    更新日期:1987-04-01 00:00:00

  • Purification and characterization of a mammalian myosin I.

    abstract::Myosin I, an actin-dependent force-generating enzyme, has been purified from three mammalian sources: bovine adrenal medulla, adrenal cortex, and brain. The purification procedure includes extraction of tissue with ATP at low ionic strength and coprecipitation with actin, followed by gel filtration on Sepharose 4B, an...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.2.490

    authors: Barylko B,Wagner MC,Reizes O,Albanesi JP

    更新日期:1992-01-15 00:00:00

  • Isolation of the tumor-inducing RNA from oncogenic and nononcogenic Agrobacterium tumefaciens.

    abstract::Two RNA fractions have been isolated and purified from both oncogenic and nononcogenic strains of Agrobacterium tumefaciens. Both RNAs are capable of inducing the formation of transplantable tumors when introduced at wound sites in stems of Datura stramonium plants. One of these RNA fractions was found to be bound to ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.5.1585

    authors: Beljanski M,Aaron-da Cunha MI,Beljanski MS,Manigault P,Bourgarel P

    更新日期:1974-05-01 00:00:00

  • Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

    abstract::The exotoxins produced by certain strains of Staphylococcus aureus are able to stimulate powerful polyclonal proliferative responses and to induce nonresponsiveness by clonal deletion of T lymphocytes expressing the appropriate T-cell antigen receptor V beta gene products. This paper examines the ability of S. aureus ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.22.8884

    authors: O'Hehir RE,Lamb JR

    更新日期:1990-11-01 00:00:00

  • Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).

    abstract::The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.17.6693

    authors: Webster GD,Sanderson MR,Skelly JV,Neidle S,Swann PF,Li BF,Tickle IJ

    更新日期:1990-09-01 00:00:00

  • N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth.

    abstract::Formation of neural circuits depends on stable contacts between neuronal processes, mediated by interaction of cell adhesion molecules, including N-cadherin. In the present study, we found that activity-dependent dendrite arborization specifically requires N-cadherin-mediated extracellular neuron-neuron interaction, b...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1003480107

    authors: Tan ZJ,Peng Y,Song HL,Zheng JJ,Yu X

    更新日期:2010-05-25 00:00:00

  • Comparing sequenced segments of the tomato and Arabidopsis genomes: large-scale duplication followed by selective gene loss creates a network of synteny.

    abstract::A 105-kilobase bacterial artificial chromosome (BAC) clone from the ovate-containing region of tomato chromosome 2 was sequenced and annotated. The tomato BAC sequence was then compared, gene by gene, with the sequenced portions of the Arabidopsis thaliana genome. Rather than matching a single portion of the Arabidops...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.160271297

    authors: Ku HM,Vision T,Liu J,Tanksley SD

    更新日期:2000-08-01 00:00:00

  • Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates.

    abstract::All vertebrate cells have been shown to contain a gene, sarc, that has some homology with the transforming gene of Rous sarcoma virus, src. We have compared the polypeptide products of the sarc gene, p60(sarc), of human, mouse, and chicken cells with the polymorphic polypeptide product of the src gene, p60(src), of se...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.4.2059

    authors: Sefton BM,Hunter T,Beemon K

    更新日期:1980-04-01 00:00:00

  • A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver.

    abstract::Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256 carcinosarcoma, and 18-day fetal rat liver. The antigen used for preparation of antiserum was the chromatin proteins initially e...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.73.9.3258

    authors: Yeoman LC,Jordan JJ,Busch RK,Taylor CW,Savage HE,Busch H

    更新日期:1976-09-01 00:00:00

  • Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.

    abstract::Multiple independent mutations in neuroligin genes were identified in patients with familial autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that NL3(R451C) knock-in mice exhibited modestly impaired social behaviors, enhanced water maze learning abilities, and increased synaptic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1111093108

    authors: Etherton M,Földy C,Sharma M,Tabuchi K,Liu X,Shamloo M,Malenka RC,Südhof TC

    更新日期:2011-08-16 00:00:00