Time-resolved resting-state brain networks.

abstract：:SUMO, a small ubiquitin-related modifier, is known to covalently attach to a number of nuclear regulatory proteins such as p53, IkappaB, promyelocytic leukemia protein and c-Jun. The sumoylation reaction is catalyzed by the SUMO protease, which exposes the C-terminal active glycine residue of the nascent SUMO, the het...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li T,Evdokimov E,Shen RF,Chao CC,Tekle E,Wang T,Stadtman ER,Yang DC,Chock PB

更新日期：2004-06-08 00:00:00

abstract：:Hypertension increases the pressure load on the heart and is associated with a poorly understood chronic systemic inflammatory state. Interleukin 33 (IL-33) binds to membrane-bound ST2 (ST2L) and has antihypertrophic and antifibrotic effects in the myocardium. In contrast, soluble ST2 appears to act as a decoy recepto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen WY,Hong J,Gannon J,Kakkar R,Lee RT

更新日期：2015-06-09 00:00:00

abstract：:Experiments were performed to ascertain the degree to which the amount of amino acids might be one of the regulatory factors that control the activity of the nucleolar RNA polymerase. Assays of the enzymatic activity were done with isolated nuclei from cells incubated with low and high concentrations of amino acids. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franze-Fernández MT,Pogo AO

更新日期：1971-12-01 00:00:00

abstract：:Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell TR

更新日期：1979-09-01 00:00:00

abstract：:The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with low concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giannakakou P,Nakano M,Nicolaou KC,O'Brate A,Yu J,Blagosklonny MV,Greber UF,Fojo T

更新日期：2002-08-06 00:00:00

abstract：:The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are important mediator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones MF,Hara T,Francis P,Li XL,Bilke S,Zhu Y,Pineda M,Subramanian M,Bodmer WF,Lal A

更新日期：2015-03-31 00:00:00

abstract：:The highly selective alpha 1-adrenergic receptor antagonist prazosin was used to identify binding sites having alpha-adrenergic specificity in rat hepatic plasma membranes. Solubilization of the membrane-bound receptors was achieved by incubation with the nonionic detergent digitonin, and binding activity was assayed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graham RM,Hess HJ,Homcy CJ

更新日期：1982-04-01 00:00:00

abstract：:We image macroscopic transient pores in mechanically stretched giant vesicles. Holes open above a critical radius r(c1), grow up to a radius r(c2), and close. We interpret the upper limit r(c2) by a relaxation of the membrane tension as the holes expand. The closing of the holes is caused by a further relaxation of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandre O,Moreaux L,Brochard-Wyart F

更新日期：1999-09-14 00:00:00

abstract：:Photonic materials with positionally ordered structure can interact strongly with light to produce brilliant structural colors. Here, we found that the nonperiodic nematic liquid crystals of nanoplates can also display structural color with only significant orientational order. Owing to the loose stacking of the nemat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng M,King D,Huang D,Do C,Wang L,Chen M,Lei S,Lin P,Chen Y,Cheng Z

更新日期：2019-09-10 00:00:00

abstract：:Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of electrolectin during myogenesis in L6 cells and rat primary muscle cultures. Antibody binding is highest to mononucleated cells and is low to myotubes in both systems. Binding is much lower to fib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Podleski TR,Greenberg I

更新日期：1980-02-01 00:00:00

abstract：:The activation of plant defensive genes in leaves of tomato plants in response to herbivore damage or mechanical wounding is mediated by a mobile 18-amino acid polypeptide signal called systemin. Systemin is derived from a larger, 200-amino acid precursor called prosystemin, similar to polypeptide hormones and soluble...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bergey DR,Howe GA,Ryan CA

更新日期：1996-10-29 00:00:00

abstract：:Angiosperms are the largest and most successful clade of land plants with >250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and sev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansen RK,Cai Z,Raubeson LA,Daniell H,Depamphilis CW,Leebens-Mack J,Müller KF,Guisinger-Bellian M,Haberle RC,Hansen AK,Chumley TW,Lee SB,Peery R,McNeal JR,Kuehl JV,Boore JL

更新日期：2007-12-04 00:00:00

abstract：:Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the functions of MRTF-B in vivo, we generated MRTF-B mutant mice by targeted inactivation of the MRTF-B gene. We show that mice hom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh J,Richardson JA,Olson EN

更新日期：2005-10-18 00:00:00

abstract：:In an effort to understand the factors that influence protein glycosylation, we are studying the expression of the chicken ovalbumin gene in a heterologous cell. Ovalbumin synthesized in mouse L-353 cells is glycosylated, as judged by incorporation of [3H]mannose and susceptibility to endo-beta-N-acetylglucosaminidase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheares BT,Robbins PW

更新日期：1986-04-01 00:00:00

abstract：:Small RNAs (sRNAs) are important components of posttranscriptional regulation. These molecules are prevalent in bacterial and eukaryotic organisms, and involved in a variety of responses to environmental stresses. The functional characterization of sRNAs is challenging and requires highly focused and extensive experim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Modi SR,Camacho DM,Kohanski MA,Walker GC,Collins JJ

更新日期：2011-09-13 00:00:00

abstract：:LINEs are transposable elements found in various eukaryotes such as plants, protists, insects, and mammals. Their transposition is usually difficult to study, particularly in humans, where some diseases have been shown to result from LINE insertion mutations. This is due to the fact that most copies of any particular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pélisson A,Finnegan DJ,Bucheton A

更新日期：1991-06-01 00:00:00

abstract：:The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky AE

更新日期：1971-12-01 00:00:00

abstract：:Economic experiments are often used to study if humans altruistically value the welfare of others. A canonical result from public-good games is that humans vary in how they value the welfare of others, dividing into fair-minded conditional cooperators, who match the cooperation of others, and selfish noncooperators. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton-Chellew MN,El Mouden C,West SA

更新日期：2016-02-02 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) has been hypothesized to function as an intercellular shuttle in the vertebrate eye, serving to transport retinoids between the retinal pigment epithelium (RPE) and photoreceptors in the process by which visual pigment is regenerated after photolysis. This hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okajima TI,Pepperberg DR,Ripps H,Wiggert B,Chader GJ

更新日期：1990-09-01 00:00:00

abstract：:Rat thoracic aortic smooth muscle cells (line A10, ATCC CRL 1476) display a high density of atrial natriuretic factor (ANF) receptors. ANF stimulated the accumulation of cGMP in these cells in a time- and dose-dependent fashion. These cells are known to display a high density of vasopressin receptors of the vascular V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nambi P,Whitman M,Gessner G,Aiyar N,Crooke ST

更新日期：1986-11-01 00:00:00

abstract：:We determined the complete nucleotide sequence of an infectious proviral molecular clone (FIV-14) of the feline immunodeficiency virus (FIV). FIV-14 has a genome organization similar in complexity to other lentiviruses. In addition to three large open reading frames representing the gag, pol, and env genes, at least f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olmsted RA,Hirsch VM,Purcell RH,Johnson PR

更新日期：1989-10-01 00:00:00

abstract：:Cardiac myosin-binding protein C (cMyBP-C) is an accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function. Its 4 N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influence actin and myosin interactions, the basic contractile proteins of muscle. Using neutron contrast variat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitten AE,Jeffries CM,Harris SP,Trewhella J

更新日期：2008-11-25 00:00:00

abstract：:Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Springer S,Zhang M,McMahon KW,Kinde I,Dobbyn L,Ptak J,Brem H,Chaichana K,Gallia GL,Gokaslan ZL,Groves ML,Jallo GI,Lim M,Olivi A,Quinones-Hinojosa A,Rigamonti D,Riggins GJ,Sciubba DM,Weingart JD,Wolinsky JP

更新日期：2015-08-04 00:00:00

abstract：:Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the underlying pathophysiology or the virulence mechanisms of the causative agent, variola virus. To improve our understanding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubins KH,Hensley LE,Jahrling PB,Whitney AR,Geisbert TW,Huggins JW,Owen A,Leduc JW,Brown PO,Relman DA

更新日期：2004-10-19 00:00:00

abstract：:Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker encodes a homologue of the moth Gram-negative bacteria-binding protein (GNBP), and another corresponds to a serine protease-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimopoulos G,Richman A,Müller HM,Kafatos FC

更新日期：1997-10-14 00:00:00

abstract：:Foraminifera are unicellular organisms that inhabit the oceans in various ecosystems. The majority of the foraminifera precipitate calcitic shells and are among the major CaCO(3) producers in the oceans. They comprise an important component of the global carbon cycle and also provide valuable paleoceanographic informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bentov S,Brownlee C,Erez J

更新日期：2009-12-22 00:00:00

abstract：:Recent functional imaging studies have revealed coactivation in a distributed network of cortical regions that characterizes the resting state, or default mode, of the human brain. Among the brain regions implicated in this network, several, including the posterior cingulate cortex and inferior parietal lobes, have al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greicius MD,Srivastava G,Reiss AL,Menon V

更新日期：2004-03-30 00:00:00

abstract：:The lipid monogalactosyl diacylglycerol (MGD) is a major structural component of photosynthetic membranes in chloroplasts. Its formation is catalyzed by the enzyme MGD synthase. In many plants, MGD derives from two different biosynthetic pathways: the prokaryotic pathway, which operates entirely within the plastid, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis P,Dörmann P,Peto CA,Lutes J,Benning C,Chory J

更新日期：2000-07-05 00:00:00

abstract：:In a passive dendritic tree, inhibitory synaptic inputs activating ionic conductances with an equilibrium potential near the resting potential can effectively veto excitatory inputs. Analog interactions of this type can be very powerful if the inputs are appropriately timed and occur at certain locations. We examine w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koch C,Poggio T,Torre V

更新日期：1983-05-01 00:00:00

abstract：:Jasmonates (JAs) are plant-specific signaling molecules that steer a diverse set of physiological and developmental processes. Pathogen attack and wounding inflicted by herbivores induce the biosynthesis of these hormones, triggering defense responses both locally and systemically. We report on alterations in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauwels L,Morreel K,De Witte E,Lammertyn F,Van Montagu M,Boerjan W,Inzé D,Goossens A

更新日期：2008-01-29 00:00:00