Dynamics of transient pores in stretched vesicles.

abstract：:We exploit the unusual genome organization of the ciliate cell to analyze the control of specific gene amplification during a nuclear differentiation process. Ciliates contain two types of nuclei within one cell, the macronucleus and the micronucleus; and after sexual reproduction a new macronucleus is formed from a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heyse G,Jönsson F,Chang WJ,Lipps HJ

更新日期：2010-12-21 00:00:00

abstract：:Electronic nematicity, a correlated state that spontaneously breaks rotational symmetry, is observed in several layered quantum materials. In contrast to their liquid-crystal counterparts, the nematic director cannot usually point in an arbitrary direction (XY nematics), but is locked by the crystal to discrete direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida K,Tsujii M,Hosoi S,Mizukami Y,Ishida S,Iyo A,Eisaki H,Wolf T,Grube K,V Löhneysen H,Fernandes RM,Shibauchi T

更新日期：2020-03-24 00:00:00

abstract：:We investigate yeast sex chromosome evolution by comparing genome sequences from 16 species in the family Saccharomycetaceae, including data from genera Tetrapisispora, Kazachstania, Naumovozyma, and Torulaspora. We show that although most yeast species contain a mating-type (MAT) locus and silent HML and HMR loci str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon JL,Armisén D,Proux-Wéra E,ÓhÉigeartaigh SS,Byrne KP,Wolfe KH

更新日期：2011-12-13 00:00:00

abstract：:A detailed model for the structure and dynamics of the interior of the lipid bilayer in the liquid crystal phase is presented. The model includes two classes of motion: (i) the internal dynamics of the chains, determined from Brownian dynamics simulations with a continuous version of the Marcelja mean-field potential,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastor RW,Venable RM,Karplus M

更新日期：1991-02-01 00:00:00

abstract：:The biological basis underlying differentiation of naive (NAI) T cells into effector (EFFE) and memory (MEM) cells is incompletely understood. Furthermore, whether NAI T cells serially differentiate into EFFE and then MEM cells (linear differentiation) or whether they concurrently differentiate into either EFFE or MEM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes S,He M,Xu T,Lee PP

更新日期：2005-04-12 00:00:00

abstract：:Genomes exhibit diverse patterns of species-specific GC content, GC and AT skews, codon bias, and mutation bias. Despite intensive investigations and the rapid accumulation of sequence data, the causes of these a priori different genome biases have not been agreed on and seem multifactorial and idiosyncratic. We show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Goldenfeld N

更新日期：2009-01-06 00:00:00

abstract：:A fundamental, yet underexplored, materials system is the interface between biological molecules and inorganic surfaces. In an elemental approach to this problem, we have systematically examined the adhesion of amino acids to a series of inorganic surfaces including metals, insulators, and semiconductors. Significant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willett RL,Baldwin KW,West KW,Pfeiffer LN

更新日期：2005-05-31 00:00:00

abstract：:We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N-terminal part of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tensen CP,Van Kesteren ER,Planta RJ,Cox KJ,Burke JF,van Heerikhuizen H,Vreugdenhil E

更新日期：1994-05-24 00:00:00

abstract：:Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mourikis P,Hurlbut GD,Artavanis-Tsakonas S

更新日期：2006-01-31 00:00:00

abstract：:Allostery plays a key role in the regulation of the activity and function of many biomolecules. And although many ligands act through allostery, no systematic use is made of it in drug design strategies. Here we describe a procedure for identifying the regions of a protein that can be used to control its activity thro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laine E,Goncalves C,Karst JC,Lesnard A,Rault S,Tang WJ,Malliavin TE,Ladant D,Blondel A

更新日期：2010-06-22 00:00:00

abstract：:A core operation in speech production is the preparation of words from a semantic base. The theory of lexical access reviewed in this article covers a sequence of processing stages beginning with the speaker's focusing on a target concept and ending with the initiation of articulation. The initial stages of preparatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levelt WJ

更新日期：2001-11-06 00:00:00

abstract：:Recent advances in understanding the role of neurotrophins on activity-dependent plasticity have provided insight into how behavior can affect specific aspects of neuronal biology. We present evidence that voluntary exercise can prime adult dorsal root ganglion neurons for increased axonal regeneration through a neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molteni R,Zheng JQ,Ying Z,Gómez-Pinilla F,Twiss JL

更新日期：2004-06-01 00:00:00

abstract：:Specific protein domains and amino acids responsible for the apparent capacity of P-glycoprotein (mdr) to recognize and transport a large group of structurally unrelated drugs have not been identified. We have introduced a single Ser----Phe substitution within the predicted TM11 domain of mdr1 (position 941) and mdr3 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gros P,Dhir R,Croop J,Talbot F

更新日期：1991-08-15 00:00:00

abstract：:Twenty-five years ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, hot biosphere" in the Earth's crust. Since this publication, a considerable amount of attention has been given to the study of deep biospheres, their role in geochemical cycles, and their potential to infor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colman DR,Poudel S,Stamps BW,Boyd ES,Spear JR

更新日期：2017-07-03 00:00:00

abstract：:A detailed experimental investigation of Fe1+y Te (y = 0.11, 0.12) using pulsed magnetic fields up to 60 T confirms remarkable magnetic shape-memory (MSM) effects. These effects result from magnetoelastic transformation processes in the low-temperature antiferromagnetic state of these materials. The observation of mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rößler S,Koz C,Wang Z,Skourski Y,Doerr M,Kasinathan D,Rosner H,Schmidt M,Schwarz U,Rößler UK,Wirth S

更新日期：2019-08-20 00:00:00

abstract：:Energy transfer is enhanced by translational diffusion of the donor and acceptor [Steinberg, I. Z. & Katchalski, E. (1968) J. Chem. Phys. 48, 2404-2410]. The effect of diffusion on energy transfer depends on Dtau(0)/s(2), in which D is the sum of the diffusion coefficients of the donor and acceptor, tau(0) is the life...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas DD,Carlsen WF,Stryer L

更新日期：1978-12-01 00:00:00

abstract：:The basic biochemical mechanisms underlying many heritable human polycystic diseases are unknown despite evidence that most cases are caused by mutations in members of several protein families, the most prominent being the polycystin gene family, whose products are found on the primary cilia, or due to mutations in po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Condac E,Silasi-Mansat R,Kosanke S,Schoeb T,Towner R,Lupu F,Cummings RD,Hinsdale ME

更新日期：2007-05-29 00:00:00

abstract：:In most Gram-positive bacteria, serine-46-phosphorylated HPr (P-Ser-HPr) controls the expression of numerous catabolic genes ( approximately 10% of their genome) by acting as catabolite corepressor. HPr kinase/phosphorylase (HprK/P), the bifunctional sensor enzyme for catabolite repression, phosphorylates HPr, a phosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mijakovic I,Poncet S,Galinier A,Monedero V,Fieulaine S,Janin J,Nessler S,Marquez JA,Scheffzek K,Hasenbein S,Hengstenberg W,Deutscher J

更新日期：2002-10-15 00:00:00

abstract：:A mouse monoclonal antibody (7E6A5) of IgG isotype, reacting specifically with mucin-producing goblet cells of the human gastrointestinal tract, has been developed. 7E6A5 reacts by an ELISA with colonic protein eluted from a DEAE column. A screening by immunoperoxidase assay of 76 specimens from 19 different human tis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vecchi M,Sakamaki S,Diamond B,Novikoff AB,Novikoff PM,Das KM

更新日期：1987-05-01 00:00:00

abstract：:It is becoming common practice to partition glass-forming liquids into two classes based on the dependence of the shear viscosity η on temperature T. In an Arrhenius plot, ln η vs 1/T, a strong liquid shows linear behavior whereas a fragile liquid exhibits an upward curvature [super-Arrhenius (SA) behavior], a situati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallamace F,Branca C,Corsaro C,Leone N,Spooren J,Chen SH,Stanley HE

更新日期：2010-12-28 00:00:00

abstract：:Various biological processes exhibit characteristics that vary dramatically in response to different input conditions or changes in the history of the process itself. One of the examples studied here, the Ras-PKC-mitogen-activated protein kinase (MAPK) bistable pathway, follows two distinct dynamics (modes) depending ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbano PE,Spivak M,Feng J,Antoniotti M,Mishra B

更新日期：2005-05-03 00:00:00

abstract：:In the preceding paper we described an experiment that determined the in vivo forward mutation rate in a single replication cycle for spleen necrosis virus. In addition to substitutions, frameshifts, and hypermutations, the mutated proviruses contained two classes of deletions. One class of deletions contained short d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pathak VK,Temin HM

更新日期：1990-08-01 00:00:00

abstract：:Antibodies previously used for immunofluorescence localization of a myosin heavy chain-like polypeptide to the nuclear envelope in higher eukaryotic cells crossreact with both muscle and nonmuscle isoforms of Drosophila myosin heavy chain. Analyses of Drosophila tissue culture cells and premyogenic embryos suggest tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berrios M,Fisher PA,Matz EC

更新日期：1991-01-01 00:00:00

abstract：:Indirect reciprocity is a mechanism for cooperation based on shared moral systems and individual reputations. It assumes that members of a community routinely observe and assess each other and that they use this information to decide who is good or bad, and who deserves cooperation. When information is transmitted pub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Schmid L,Tkadlec J,Chatterjee K,Nowak MA

更新日期：2018-11-27 00:00:00

abstract：:To clone the gene for the human Na+/H+ antiporter, we first constructed a stable mouse LTK- cell line (LAP1) lacking Na+/H+ antiport activity. Second, we devised a selective technique based on acid killing that specifically sorts out cells expressing low levels of Na+/H+ antiport activity from a population of antiport...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franchi A,Perucca-Lostanlen D,Pouyssegur J

更新日期：1986-12-01 00:00:00

abstract：:Bruton tyrosine kinase (EC 2.7.1.112) [Btk, encoded by Btk in mice and BTK in humans (formerly known as atk, BPK, or emb)], which is variously mutated in chromosome X-linked agammaglobulinemia patients and X-linked immunodeficient (xid) mice, has the pleckstrin homology (PH) domain at its amino terminus. The PH domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao L,Kawakami Y,Kawakami T

更新日期：1994-09-13 00:00:00

abstract：:Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux EF,Wohlever ML,Chen JZ,Sauer RT,Baker TA

更新日期：2013-05-28 00:00:00

abstract：:The effect of Zn2+ on a voltage-dependent, transient potassium current (IA) in acutely dissociated neurons from the suprachiasmatic nucleus was studied with the whole-cell patch-clamp technique. At micromolar concentrations, Zn2+ markedly potentiated IA activated from a holding potential of -60 mV, which is the restin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RC,Peng YW,Yau KW

更新日期：1993-12-15 00:00:00

abstract：:BHK cells were inoculated sparsely on one face ("sparse- or s-face") of a thin glass film whose opposite face was covered with a 2- to 3-day-old confluent layer of BHK cells ("confluent- or c-face"). After 7 hr of attaching and spreading in the absence of visible light, most of the cells on the s-face traversed with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht-Buehler G

更新日期：1992-09-01 00:00:00

abstract：:The rate of derepressed synthesis of a membrane protein required for lactose transport (M protein) by Escherichia coli is increased in response to increased gene dosage to the same extent as the rates of synthesis of beta-galactosidase and galactoside acetylase. However, elevated gene dosage does not increase beta-gal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox CF

更新日期：1969-07-01 00:00:00