Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.

abstract：:This paper provides transcendental and algebraic framework for the classification of identities expressing pi and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky DV,Chudnovsky GV

更新日期：1998-03-17 00:00:00

abstract：:The release of catecholamines from adrenal chromaffin cells is known to be blocked by dihydropyridines, such as nitrendipine, and enhanced by others, such as BAY K8644. On the other hand, release from sympathetic neurons is predominantly insensitive to these agents. Release of [3H]norepinephrine from undifferentiated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsamut S,Miller RJ

更新日期：1986-04-01 00:00:00

abstract：:The polyhedral borane ion [n-B20H18]2- reacts with liquid ammonia in the presence of a suitable base to produce an apical-equatorial (ae) isomer of the [B20H17NH3]3- ion, [1-(2'-B10H9)-2-NH3B10H8]3-. The structure of this product has been confirmed by 11B NMR spectroscopy and x-ray crystallography. This species underg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feakes DA,Shelly K,Knobler CB,Hawthorne MF

更新日期：1994-04-12 00:00:00

abstract：:RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin JC,Hsu M,Tarn WY

更新日期：2007-02-13 00:00:00

abstract：:Multidrug resistance in Gram-negative bacteria, to which multidrug efflux pumps such as the AcrB transporter makes a major contribution, is becoming a major public health problem. Unfortunately only a few compounds have been cocrystallized with AcrB, and thus computational approaches are essential in elucidating the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vargiu AV,Nikaido H

更新日期：2012-12-11 00:00:00

abstract：:Psychopathy is associated with persistent antisocial behavior and a striking lack of regret for the consequences of that behavior. Although explanatory models for psychopathy have largely focused on deficits in affective responsiveness, recent work indicates that aberrant value-based decision making may also play a ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baskin-Sommers A,Stuppy-Sullivan AM,Buckholtz JW

更新日期：2016-12-13 00:00:00

abstract：:Efficient apoptotic cell clearance and induction of immunologic tolerance is a critical mechanism preventing autoimmunity and associated pathology. Our laboratory has reported that apoptotic cells induce tolerance by a mechanism dependent on the tryptophan catabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) in sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravishankar B,Liu H,Shinde R,Chaudhary K,Xiao W,Bradley J,Koritzinsky M,Madaio MP,McGaha TL

更新日期：2015-08-25 00:00:00

abstract：:We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root ganglion neurons from mice were exposed to various pharmacological agents (challenge compounds), while ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teichert RW,Smith NJ,Raghuraman S,Yoshikami D,Light AR,Olivera BM

更新日期：2012-01-31 00:00:00

abstract：:Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus without a decline in host fitness, varies across tissues, environmental conditions, and physiologic states. While disease tolerance is a known strategy of host defense, its role in noninfectious diseases has been understudied. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Man K,Bowman C,Braverman KN,Escalante V,Tian Y,Bisanz JE,Ganeshan K,Wang B,Patterson A,Bayrer JR,Turnbaugh PJ,Chawla A

更新日期：2020-12-15 00:00:00

abstract：:Oncolytic viruses constitute a promising therapy against malignant gliomas (MGs). However, virus-induced type I IFN greatly limits its clinical application. The kinase mammalian target of rapamycin (mTOR) stimulates type I IFN production via phosphorylation of its effector proteins, 4E-BPs and S6Ks. Here we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alain T,Lun X,Martineau Y,Sean P,Pulendran B,Petroulakis E,Zemp FJ,Lemay CG,Roy D,Bell JC,Thomas G,Kozma SC,Forsyth PA,Costa-Mattioli M,Sonenberg N

更新日期：2010-01-26 00:00:00

abstract：:We have constructed and characterized a polyoma virus-based plasmid that is maintained as an autonomously replicating extrachromosomal element (episome) in mouse embryonic stem (ES) cells. Plasmid pMGD20neo contains the polyoma origin of replication harboring a mutated enhancer (PyF101), a modified polyoma early regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gassmann M,Donoho G,Berg P

更新日期：1995-02-28 00:00:00

abstract：:Changes in the expression of Hox genes have been widely linked to the evolution of animal body plans, but functional demonstrations of this relationship have been impeded by the lack of suitable model organisms. A classic case study involves the repeated evolution of specialized feeding appendages, called maxillipeds,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlopoulos A,Kontarakis Z,Liubicich DM,Serano JM,Akam M,Patel NH,Averof M

更新日期：2009-08-18 00:00:00

abstract：:Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1974-05-01 00:00:00

abstract：:Neuroglobin (Ngb), a vertebrate globin expressed primarily in neurons, is induced by and protects against neuronal hypoxia and cerebral ischemia. To investigate the spectrum and mechanism of Ngb's neuroprotective action, we studied the effect of transgenic overexpression of Ngb on NMDA and beta-amyloid (Abeta) toxicit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AA,Mao XO,Banwait S,Jin K,Greenberg DA

更新日期：2007-11-27 00:00:00

abstract：:During natural fertilization, mammalian spermatozoa must pass through the zona pellucida before reaching the plasma membrane of the oocyte. It is assumed that this step involves partial lysis of the zona by sperm acrosomal enzymes, but there has been no unequivocal evidence to support this view. Here we present eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose M,Honda A,Fulka H,Tamura-Nakano M,Matoba S,Tomishima T,Mochida K,Hasegawa A,Nagashima K,Inoue K,Ohtsuka M,Baba T,Yanagimachi R,Ogura A

更新日期：2020-02-04 00:00:00

abstract：:DNA containing 5-azacytosine (azaC) has previously been shown to be a potent inhibitor of DNA-cytosine methyltransferases. In this report, we describe experiments which demonstrate that azaC-DNA forms a covalent complex with Hpa II methylase, a bacterial enzyme that methylates the internal C of C-C-G-G sequences. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santi DV,Norment A,Garrett CE

更新日期：1984-11-01 00:00:00

abstract：:Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo-Noriega EN,Sathyamoorthi S,Banerjee S,Gnanamani E,Mendoza-Trujillo M,Mata-Espinosa D,Hernández-Pando R,Veytia-Bucheli JI,Possani LD,Zare RN

更新日期：2019-06-25 00:00:00

abstract：:Traumatic brain injury (TBI) causes neuronal apoptosis, inflammation, and reactive astrogliosis, which contribute to secondary tissue loss, impaired regeneration, and associated functional disabilities. Here, we show that up-regulation of cell cycle components is associated with caspase-mediated neuronal apoptosis and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Giovanni S,Movsesyan V,Ahmed F,Cernak I,Schinelli S,Stoica B,Faden AI

更新日期：2005-06-07 00:00:00

abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh H,Medina KL,Pongubala JM

更新日期：2005-04-05 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) glutamate receptor-mediated increases in intracellular calcium are thought to play a critical role in synaptic plasticity. The mechanisms by which changes in cytoplasmic calcium transmit the glutamate signal to the nucleus, which is ultimately important for long-lasting neuronal responses, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun HY,Gonzalez-Zulueta M,Dawson VL,Dawson TM

更新日期：1998-05-12 00:00:00

abstract：:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the nc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles BA,Hawley RS

更新日期：1991-08-15 00:00:00

abstract：:Sets of Burkitt lymphoma lines and Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) derived from the same individuals were compared for sensitivity to cytotoxic T-lymphocyte (CTL) clones. Major histocompatibility complex class I antigen-restricted CTL clones were generated by stimulating the lymph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torsteinsdottir S,Masucci MG,Ehlin-Henriksson B,Brautbar C,Ben Bassat H,Klein G,Klein E

更新日期：1986-08-01 00:00:00

abstract：:We demonstrate that the BC200 RNA gene, which encodes a neural small cytoplasmic RNA, is a member of the most prodigious family of interspersed repetitive DNA and that its product represents an example of a primate tissue-specific RNA polymerase III transcript. The BC200 RNA gene is an early monomeric member and one o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martignetti JA,Brosius J

更新日期：1993-12-15 00:00:00

abstract：:To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe N,Katakura K,Kobayashi A,Okumura K,Ovary Z

更新日期：1988-06-01 00:00:00

abstract：:Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ponmalar II,Cheerla R,Ayappa KG,Basu JK

更新日期：2019-06-25 00:00:00

abstract：:Synchrotron far-IR spectroscopy and density-functional calculations are used to characterize the low-frequency dynamics of model heme FeCO compounds. The "doming" vibrational mode in which the iron atom moves out of the porphyrin plane while the periphery of this ring moves in the opposite direction determines the rea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klug DD,Zgierski MZ,Tse JS,Liu Z,Kincaid JR,Czarnecki K,Hemley RJ

更新日期：2002-10-01 00:00:00

abstract：:A G to T mutation has been observed at the third position of codon 249 of the p53 tumor-suppressor gene in over 50% of the hepatocellular carcinoma cases associated with high exposure to aflatoxin B(1) (AFB(1)). Hypotheses have been put forth that AFB(1), in concert with hepatitis B virus (HBV), may play a role in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smela ME,Hamm ML,Henderson PT,Harris CM,Harris TM,Essigmann JM

更新日期：2002-05-14 00:00:00

abstract：:In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human beta-globin LCRs are homologous, indicating conservation of an essential function in beta-globin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulger M,van Doorninck JH,Saitoh N,Telling A,Farrell C,Bender MA,Felsenfeld G,Axel R,Groudine M

更新日期：1999-04-27 00:00:00

abstract：:Titania, which exhibits superwetting under light illumination, has been widely used as an ideal material for environmental solution such as self-cleaning, water-air purification, and antifogging. There have been various studies to understand such superhydrophilic conversion. The origin of superwetting has not been cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee K,Kim Q,An S,An J,Kim J,Kim B,Jhe W

更新日期：2014-04-22 00:00:00

abstract：:The retroviral integrase protein (IN) is responsible for catalyzing a concerted integration reaction in which the two termini of linear viral DNA are joined to host DNA. To probe the potential for IN to form protein multimers, we used the yeast two-hybrid system. The coexpression of a GAL4 DNA binding domain-IN fusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalpana GV,Goff SP

更新日期：1993-11-15 00:00:00