Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo.

abstract：:The geographical structure of a population distributed continuously and homogeneously along an infinite linear habitat is explored. The analysis is restricted to a single locus in the absence of selection, and every mutant is assumed to be new to the population. An explicit formula is derived for the probability that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagylaki T

更新日期：1974-08-01 00:00:00

abstract：:Over the past decade, seafood mislabeling has been increasingly documented, raising public concern over the identity, safety, and sustainability of seafood. Negative outcomes from seafood mislabeling are suspected to be substantial and pervasive as seafood is the world's most highly traded food commodity. Here we prov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroetz K,Luque GM,Gephart JA,Jardine SL,Lee P,Chicojay Moore K,Cole C,Steinkruger A,Donlan CJ

更新日期：2020-12-01 00:00:00

abstract：:Oligodeoxyribonucleotides covalently linked to an intercalating agent via a polymethylene linker were synthesized. Oligothymidylates attached to an acridine dye (Acr) through the 3'-phosphate group [(Tp)n(CH2) mAcr ] specifically interact with the complementary sequence. The interaction is strongly stabilized by the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asseline U,Delarue M,Lancelot G,Toulmé F,Thuong NT,Montenay-Garestier T,Hélène C

更新日期：1984-06-01 00:00:00

abstract：:The mammalian hair follicle unit consists of a central follicle and a series of associated structures: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings. The architecture of this multicellular structure is highly polarized with respect to the body axes. Previous work has implicated Frizz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang H,Nathans J

更新日期：2013-03-05 00:00:00

abstract：:It is widely accepted that modern humans originated in sub-Saharan Africa approximately 150-200 thousand years ago (ka), but their route of dispersal across the currently hyperarid Sahara remains controversial. Given that the first modern humans north of the Sahara are found in the Levant approximately 120-90 ka, nort...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osborne AH,Vance D,Rohling EJ,Barton N,Rogerson M,Fello N

更新日期：2008-10-28 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5) are tau kinases and have been proposed to contribute to the pathogenesis of Alzheimer's disease. The 3D structures of these kinases are remarkably similar, which led us to hypothesize that both might be capable of binding cyclin proteins--the act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow HM,Guo D,Zhou JC,Zhang GY,Li HF,Herrup K,Zhang J

更新日期：2014-11-11 00:00:00

abstract：:The product of the recA gene of E. coli has been identified by labeling proteins synthesized in UV-treated cells after infection with specialized transducing phages carrying the recA gene. Following infection of UV-treated cells by lambda precA, which carries the recA+ gene, a major protein with a molecular weight of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McEntee K,Hesse JE,Epstein W

更新日期：1976-11-01 00:00:00

abstract：:We recently reported that the posttraumatic spread of degeneration in the damaged optic nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic protein. However, it would be desirable to obtain immune neuroprotection free of any possible autoimmune disease. In an attempt to obta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipnis J,Yoles E,Porat Z,Cohen A,Mor F,Sela M,Cohen IR,Schwartz M

更新日期：2000-06-20 00:00:00

abstract：:Oxidative stress induced in live HeLa cells by menadione (2-methyl-1,4-napthaquinone) was studied in real time by scanning electrochemical microscopy (SECM). The hydrophobic molecule menadione diffuses through a living cell membrane where it is toxic to the cell. However, in the cell it is conjugated with glutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koley D,Bard AJ

更新日期：2012-07-17 00:00:00

abstract：:Junctions that mediate excitation-contraction (e-c) coupling are formed between the sarcoplasmic reticulum (SR) and either the surface membrane or the transverse (T) tubules in normal skeletal muscle. Two structural components of the junctions, the feet of the SR and the tetrads of T tubules, have been identified resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takekura H,Nishi M,Noda T,Takeshima H,Franzini-Armstrong C

更新日期：1995-04-11 00:00:00

abstract：:Ecological interactions shape adaptations through coevolution not only between pairs of species but also through entire multispecies assemblages. Local coevolution can then be further altered through spatial processes that have been formally partitioned in the geographic mosaic theory of coevolution. A major current c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medeiros LP,Garcia G,Thompson JN,Guimarães PR Jr

更新日期：2018-11-20 00:00:00

abstract：:With Manduca sexta as a model system, we analyzed how natural odor mixtures that are most effective in eliciting flight and foraging behaviors are encoded in the primary olfactory center in the brain, the antennal lobe. We used gas chromatography coupled with multiunit neural-ensemble recording to identify key odorant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Riffell JA,Lei H,Hildebrand JG

更新日期：2009-11-17 00:00:00

abstract：:Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor growth but is required ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Zhang W,Font-Burgada J,Palmer T,Hamil AS,Biswas SK,Poidinger M,Borcherding N,Xie Q,Ellies LG,Lytle NK,Wu LW,Fox RG,Yang J,Dowdy SF,Reya T,Karin M

更新日期：2014-09-23 00:00:00

abstract：:High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens in clinical samples. Conventional metagenomic sequencing, however, does not integrate information about the host, which is often critical to distinguish infection from infectious disease, and to assess the severity of disease. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng AP,Burnham P,Lee JR,Cheng MP,Suthanthiran M,Dadhania D,De Vlaminck I

更新日期：2019-09-10 00:00:00

abstract：:The immunocytochemical demonstration of (pro)insulin on intracellular membrane compartments of the pancreatic B cell reveals that the immunolabeling detected by the protein A/gold method is associated, at the level of the Golgi apparatus, with the inner aspect of the cisternal membranes; on the secretory granules, by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orci L,Ravazzola M,Perrelet A

更新日期：1984-11-01 00:00:00

abstract：:Agrobacterium tumefaciens transfers the T-DNA portion of its Ti plasmid to the nuclear genome of plant cells. Upon cocultivation of A. tumefaciens strain A348 with regenerating tobacco leaf protoplasts, restriction endonuclease fragments of the T-DNA were generated that are consistent with double-stranded cleavage of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veluthambi K,Jayaswal RK,Gelvin SB

更新日期：1987-04-01 00:00:00

abstract：:Purified cellular retinol-binding protein (CRBP), a potential mediator of vitamin A action, was found to enable retinol to bind in a specific manner to isolated nuclei from livers of vitamin A deficient rats. Binding was followed after complexing [3H]retinol with CRBP. The binding was specific, saturable, and temperat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takase S,Ong DE,Chytil F

更新日期：1979-05-01 00:00:00

abstract：:The activation of plant defensive genes in leaves of tomato plants in response to herbivore damage or mechanical wounding is mediated by a mobile 18-amino acid polypeptide signal called systemin. Systemin is derived from a larger, 200-amino acid precursor called prosystemin, similar to polypeptide hormones and soluble...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bergey DR,Howe GA,Ryan CA

更新日期：1996-10-29 00:00:00

abstract：:Interactions between two excitatory monosynaptic inputs to hippocampal neurons of the CA1 region were examined in the in vitro slice. By adjusting the strengths of the electrical stimuli delivered to the two input pathways, one was made to generate a weak and the other a strong synaptic response. Simultaneous tetanic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrionuevo G,Brown TH

更新日期：1983-12-01 00:00:00

abstract：:A reversible growth arrest of simian virus 40-transformed human fibroblasts has been produced by replacement of methionine in the growth medium by its immediate metabolic precursor, homocysteine, Although these arrested cells exhibit a greatly reduced cloning efficiency when plated in methionine-supplemented medium, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman RM,Jacobsen SJ

更新日期：1980-12-01 00:00:00

abstract：:Direct visualization of genomic loci in the 3D nucleus is important for understanding the spatial organization of the genome and its association with gene expression. Various DNA FISH methods have been developed in the past decades, all involving denaturing dsDNA and hybridizing fluorescent nucleic acid probes. Here w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng W,Shi X,Tjian R,Lionnet T,Singer RH

更新日期：2015-09-22 00:00:00

abstract：:A conformational isoform of the mammalian prion protein (PrP(Sc)) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-beta diffraction: meridional intensity at 4.8 A resolution, indicating the presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Bian W,McDonald M,Kendall A,Colby DW,Bloch L,Ollesch J,Borovinskiy AL,Cohen FE,Prusiner SB,Stubbs G

更新日期：2009-10-06 00:00:00

abstract：:The phenotype of several erythromycin-resistant mutants of Chlamydomonas reinhardi was further characterized in terms of the electrophoretic properties of their chloroplast ribosomal proteins. In mutant ery-M2d a single protein of the large (52 S) subunit has altered properties, which probably result from a change in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mets L,Bogorad L

更新日期：1972-12-01 00:00:00

abstract：:In light of the rapid recent retreat of Arctic sea ice, a number of studies have discussed the possibility of a critical threshold (or "tipping point") beyond which the ice-albedo feedback causes the ice cover to melt away in an irreversible process. The focus has typically been centered on the annual minimum (Septemb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenman I,Wettlaufer JS

更新日期：2009-01-06 00:00:00

abstract：:Muscular dystrophy is a general term encompassing muscle disorders that cause weakness and wasting, typically leading to premature death. Membrane instability, as a result of a genetic disruption within the dystrophin-glycoprotein complex (DGC), is thought to induce myofiber degeneration, although the downstream mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millay DP,Goonasekera SA,Sargent MA,Maillet M,Aronow BJ,Molkentin JD

更新日期：2009-11-10 00:00:00

abstract：:A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of "proximally exposed" parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neel JV,Satoh C,Hamilton HB,Otake M,Goriki K,Kageoka T,Fujita M,Neriishi S,Asakawa J

更新日期：1980-07-01 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:Membraneless organelles contain a wide spectrum of molecular chaperones, indicating their important roles in modulating the metastable conformation and biological function of membraneless organelles. Here we report that class I and II Hsp40 (DNAJ) proteins possess a high ability of phase separation rendered by the fle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu J,Liu Z,Zhang S,Li Y,Xia W,Wang C,Xiang H,Liu Z,Tan L,Fang Y,Liu C,Li D

更新日期：2020-12-08 00:00:00

abstract：:Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westin EH,Wong-Staal F,Gelmann EP,Dalla-Favera R,Papas TS,Lautenberger JA,Eva A,Reddy EP,Tronick SR,Aaronson SA,Gallo RC

更新日期：1982-04-01 00:00:00

abstract：:The free energy difference between complexes of the restriction nuclease EcoRI with nonspecific DNA and with the enzyme's recognition sequence is linearly dependent on the water chemical potential of the solution, set using several very different solutes, ranging from glycine and glycerol to triethylene glycol and suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidorova NY,Rau DC

更新日期：1996-10-29 00:00:00