Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

abstract：:Osmotic homeostasis in the brain involves movement of water through aquaporin-4 (AQP4) membrane channels. Perivascular astrocyte end-feet contain distinctive orthogonal lattices (square arrays) assembled from 4- to 6-nm intramembrane particles (IMPs) corresponding to individual AQP4 tetramers. Two isoforms of AQP4 res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman CS,Gorelick-Feldman DA,Davidson KG,Yasumura T,Neely JD,Agre P,Rash JE

更新日期：2003-11-11 00:00:00

abstract：:The output of the cerebellar cortex is controlled by two main inputs, (i.e., the climbing fiber and mossy fiber-parallel fiber pathway) and activations of these inputs elicit characteristic effects in its Purkinje cells: that is, the so-called complex spikes and simple spikes. Target neurons of the Purkinje cells in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoebeek FE,Witter L,Ruigrok TJ,De Zeeuw CI

更新日期：2010-05-04 00:00:00

abstract：:Toll like receptors (TLRs) use Toll-IL-1 receptor (TIR) domain-containing adapters, such as myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adapter inducing IFN-β (TRIF), to induce activation of transcription factors, including NF-κB, MAP kinases, and IFN regulatory factors. TLR sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Troutman TD,Hu W,Fulenchek S,Yamazaki T,Kurosaki T,Bazan JF,Pasare C

更新日期：2012-01-03 00:00:00

abstract：:The chronometric redshift-distance relation z = tan 2(1/2rho), where rho is the distance in radians in the Einstein metric, is derived by an elementary geometric analysis comparable to that in traditional analysis of the expanding universe model. The differential dTt of Einstein time evolution Tt through time t, as ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segal IE

更新日期：1993-12-01 00:00:00

abstract：:Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hengerer B,Lindholm D,Heumann R,Rüther U,Wagner EF,Thoenen H

更新日期：1990-05-01 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:I measured the strength of interaction between a marine herbivore and its growing resource over a realistic range of absolute and relative abundances. The herbivores (hermit crabs: Pagurus spp.) have slow and/or weak functional and numerical responses to epiphytic diatoms (Isthmia nervosa), which show logistic growth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruesink JL

更新日期：1998-06-09 00:00:00

abstract：:Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the beta(1)-adrenergic receptor (beta(1)AR), a beta-blocker target, as candidate pharmacogenomic loci. Transfected cells, genotyped human nonfailing and failing ventricles, and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liggett SB,Mialet-Perez J,Thaneemit-Chen S,Weber SA,Greene SM,Hodne D,Nelson B,Morrison J,Domanski MJ,Wagoner LE,Abraham WT,Anderson JL,Carlquist JF,Krause-Steinrauf HJ,Lazzeroni LC,Port JD,Lavori PW,Bristow MR

更新日期：2006-07-25 00:00:00

abstract：:Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that promote insulin action. Serine phosphorylation uncouples IRS-1 from the insulin receptor, thereby inhibiting its tyrosine phosphorylation and insulin signaling....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozes ON,Akca H,Mayo LD,Gustin JA,Maehama T,Dixon JE,Donner DB

更新日期：2001-04-10 00:00:00

abstract：:The genomic sequences encoding the human lysosomal acid lipase/cholesteryl esterase (sterol esterase; EC 3.1.1.13) have been isolated and sequenced, and the information has been used to identify mutations in both alleles of the gene from a patient with Wolman disease, an autosomal recessive lysosomal lipid storage dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson RA,Byrum RS,Coates PM,Sando GN

更新日期：1994-03-29 00:00:00

abstract：:Interleukin 1 (IL-1) is a two-member family of proteins (IL-1 alpha and IL-1 beta) that mediates a diverse series of immune and inflammatory responses. These two proteins have only 26% amino acid homology yet bind to the same receptor. It is of importance to define the active sites of these molecules in order to under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosley B,Dower SK,Gillis S,Cosman D

更新日期：1987-07-01 00:00:00

abstract：:Transabdominal (Tab) is a dominant gain-of-function mutation that results in islands of sexually dimorphic abdominal cuticle in the dorsal thorax of the adult fly. This phenotype has complete penetrance and constant expressivity, and we show that it results from ectopic expression of ABD-BII, one of two proteins deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Celniker SE,Lewis EB

更新日期：1993-02-15 00:00:00

abstract：:Forkhead box class O (FoxO) transcription factors are key regulators of growth, metabolism, life span, and stress resistance. FoxOs integrate signals from different pathways and guide the cellular response to varying energy and stress conditions. FoxOs are modulated by several signaling pathways, e.g., the insulin-TOR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattila J,Kallijärvi J,Puig O

更新日期：2008-09-30 00:00:00

abstract：:We have used a soluble in vitro RNA polymerase II transcription system to define the site of initiation of Moloney murine leukemia viral RNA synthesis. Molecularly cloned integrated and unintegrated Moloney murine leukemia virus DNAs were used as templates. The 5' ends of in vitro transcripts and virion RNA of Moloney...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuhrman SA,Van Beveren C,Verma IM

更新日期：1981-09-01 00:00:00

abstract：:Transposable elements make up half of the mammalian genome. One of the most abundant is the short interspersed nuclear element (SINE). Among their million copies, B2 accounts for ∼350,000 in the mouse genome and has garnered special interest because of emerging roles in epigenetic regulation. Our recent work demonstra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hernandez AJ,Zovoilis A,Cifuentes-Rojas C,Han L,Bujisic B,Lee JT

更新日期：2020-01-07 00:00:00

abstract：:The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyckman AW,Horng S,Leamey CA,Tropea D,Watakabe A,Van Wart A,McCurry C,Yamamori T,Sur M

更新日期：2008-07-08 00:00:00

abstract：:Chemomechanical coupling in muscle contraction may be due to "swinging crossbridges," such that a change in the angle at which the myosin head binds to the actin filament is tightly coupled to release of products of ATP hydrolysis. This model would limit the step size, the unit displacement of actin produced by a sing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyoshima YY,Kron SJ,Spudich JA

更新日期：1990-09-01 00:00:00

abstract：:Nutrition recommendations worldwide emphasize ingestion of plant-based diets rather than diets that rely primarily on animal products. However, this plant-based diet could limit the intake of essential nutrients such as calcium. Osteoporosis is one of the world's most prevalent nutritional disorders, and inadequate di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris J,Hawthorne KM,Hotze T,Abrams SA,Hirschi KD

更新日期：2008-02-05 00:00:00

abstract：:By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness char...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyeon C,Thirumalai D

更新日期：2003-09-02 00:00:00

abstract：:Despite the importance of Mg(2+) for numerous cellular activities, the mechanisms underlying its import and homeostasis are poorly understood. The CorA family is ubiquitous and is primarily responsible for Mg(2+) transport. However, the key questions-such as, the ion selectivity, the transport pathway, and the gating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guskov A,Nordin N,Reynaud A,Engman H,Lundbäck AK,Jong AJ,Cornvik T,Phua T,Eshaghi S

更新日期：2012-11-06 00:00:00

abstract：:Recombinant immunotoxins (RITs) are chimeric proteins composed of an Fv and a protein toxin being developed for cancer treatment. The Fv brings the toxin to the cancer cell, but most of the RITs do not reach the tumor and are removed by other organs. To identify cells responsible for RIT removal, and the pathway by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu XF,Wei J,Zhou Q,Molitoris BA,Sandoval R,Kobayashi H,Okada R,Nagaya T,Karim B,Butcher D,Pastan I

更新日期：2020-03-17 00:00:00

abstract：:Women outnumber men in undergraduate enrollments, but they are much less likely than men to major in mathematics or science or to choose a profession in these fields. This outcome often is attributed to the effects of negative sex-based stereotypes. We studied the effect of such stereotypes in an experimental market, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reuben E,Sapienza P,Zingales L

更新日期：2014-03-25 00:00:00

abstract：:Arf family GTP-binding proteins are best characterized as regulators of membrane traffic, but recent studies indicate an additional role in cytoskeletal organization. An Arf GTPase-activating protein of the centaurin beta family, ASAP1 (also known as centaurin beta4), binds Arf and two other known regulators of the ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randazzo PA,Andrade J,Miura K,Brown MT,Long YQ,Stauffer S,Roller P,Cooper JA

更新日期：2000-04-11 00:00:00

abstract：:Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

更新日期：2003-11-25 00:00:00

abstract：:NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glutamate binding to g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iacobucci GJ,Wen H,Helou M,Liu B,Zheng W,Popescu GK

更新日期：2021-01-12 00:00:00

abstract：:We have previously shown that hepatitis B virus (HBV) replication is controlled by noncytolytic mechanisms that depend primarily on the effector functions of the CD8(+) T cell response, especially the production of IFN-gamma in the liver. The mechanisms that control the nuclear pool of viral covalently closed circular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wieland SF,Spangenberg HC,Thimme R,Purcell RH,Chisari FV

更新日期：2004-02-17 00:00:00

abstract：:Adeno-associated virus (AAV) is a small human Dependovirus whose low immunogenicity and capacity for long-term persistence have led to its widespread use as vector for gene therapy. Despite great recent successes in AAV-based gene therapy, further improvements in vector technology may be hindered by an inadequate unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith-Moore S,Neil SJD,Fraefel C,Linden RM,Bollen M,Rowe HM,Henckaerts E

更新日期：2018-04-10 00:00:00

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang X,Gu L,Qi J,Correa S,Zhang G,Belcher AM,Hammond PT

更新日期：2016-05-10 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00

abstract：:Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs). T cells fail...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cobbold SP,Adams E,Farquhar CA,Nolan KF,Howie D,Lui KO,Fairchild PJ,Mellor AL,Ron D,Waldmann H

更新日期：2009-07-21 00:00:00