Abstract:
:The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and proteins that mediate synaptic plasticity. DNA microarray analysis of transcription in mouse V1 before, during, and after the critical period identified 31 genes that were up-regulated and 22 that were down-regulated during the critical period. The highest-ranked up-regulated gene, cardiac troponin C, codes for a neuronal calcium-binding protein that regulates actin binding and whose expression is activity-dependent and relatively selective for layer-4 star pyramidal neurons. The highest-ranked down-regulated gene, synCAM, also has actin-based function. Actin-binding function, G protein signaling, transcription, and myelination are prominently represented in the critical period transcriptome. Monocular deprivation during the critical period reverses the expression of nearly all critical period genes. The profile of regulated genes suggests that synaptic stability is a principle driver of critical period gene expression and that alteration in visual activity drives homeostatic restoration of stability.
journal_name
Proc Natl Acad Sci U S Aauthors
Lyckman AW,Horng S,Leamey CA,Tropea D,Watakabe A,Van Wart A,McCurry C,Yamamori T,Sur Mdoi
10.1073/pnas.0710172105subject
Has Abstractpub_date
2008-07-08 00:00:00pages
9409-14issue
27eissn
0027-8424issn
1091-6490pii
0710172105journal_volume
105pub_type
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