The structure of chromatin.

abstract：:Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson WE,Cheng DS,Degryse AL,Tanjore H,Polosukhin VV,Xu XC,Newcomb DC,Jones BR,Roldan J,Lane KB,Morrisey EE,Beers MF,Yull FE,Blackwell TS

更新日期：2011-06-28 00:00:00

abstract：:Marked hypoalphalipoproteinemia was found together with relatively low serum cholesterol, triacylglycerol, and LDL levels in a triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1)-deficient Hungarian family, especially in the two compound-heterozygote brothers. Apart from a slight...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollán S,Dey I,Szollár L,Horányi M,Magócsi M,Harsányi V,Farkas T

更新日期：1995-01-03 00:00:00

abstract：:The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Pléau JM,Nabarra B,Lefrancier P,Derrien M,Choay J,Bach JF

更新日期：1982-09-01 00:00:00

abstract：:Methylmalonyl-CoA mutase (EC 5.4.99.2) is a mitochondrial matrix enzyme whose activity is deficient in the inherited disorder methylmalonic acidemia. Previous studies on primary fibroblast cell lines from patients with methylmalonic acidemia have delineated a variety of biochemical phenotypes underlying this disorder....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledley FD,Jansen R,Nham SU,Fenton WA,Rosenberg LE

更新日期：1990-04-01 00:00:00

abstract：:The bacterial transposon Tn7 encodes two distinct but overlapping transposition pathways. tnsABC + tnsD promote transposition to a specific site, attTn7, while tnsABC + tnsE promote transposition to many other sites unrelated to attTn7. We have identified a tnsD-dependent DNA binding activity that specifically recogni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waddell CS,Craig NL

更新日期：1989-06-01 00:00:00

abstract：:Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not ref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin KM,Belser JA,Wadford DA,Pearce MB,Katz JM,Tumpey TM,Maines TR

更新日期：2011-05-17 00:00:00

abstract：:Metagenomics is expanding our knowledge of the gene content, functional significance, and genetic variability in natural microbial communities. Still, there exists limited information concerning the regulation and dynamics of genes in the environment. We report here global analysis of expressed genes in a naturally oc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frias-Lopez J,Shi Y,Tyson GW,Coleman ML,Schuster SC,Chisholm SW,Delong EF

更新日期：2008-03-11 00:00:00

abstract：:Natural environments are filled with multiple, often competing, signals. In contrast, biological systems are often studied in "well-controlled" environments where only a single input is varied, potentially missing important interactions between signals. Catabolite repression of galactose by glucose is one of the best-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escalante-Chong R,Savir Y,Carroll SM,Ingraham JB,Wang J,Marx CJ,Springer M

更新日期：2015-02-03 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00

abstract：:Streptococcus groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Yet, despite their apparent importance in infection, the structure of the Ri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whelan F,Lafita A,Griffiths SC,Cooper REM,Whittingham JL,Turkenburg JP,Manfield IW,St John AN,Paci E,Bateman A,Potts JR

更新日期：2019-12-09 00:00:00

abstract：:An inborn deficiency in the ability of aldolase B to split fructose 1-phosphate is found in humans with hereditary fructose intolerance (HFI). A stable isotope procedure to elucidate the mechanism of conversion of fructose to glucose in normal children and in HFI children has been developed. A constant infusion of D-[...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gopher A,Vaisman N,Mandel H,Lapidot A

更新日期：1990-07-01 00:00:00

abstract：:Germinal centers (GCs) are specialized microenvironments in secondary lymphoid organs where high-affinity antibody-producing B cells are selected based on B-cell antigen receptor (BCR) signal strength. BCR signaling required for normal GC selection is uncertain. We have found that protein kinase N1 (PKN1, also known a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Sakakibara-Yada K,Nishimura T,Morita K,Tada S,Mosialos G,Kieff E,Kikutani H

更新日期：2012-12-18 00:00:00

abstract：:Among the most striking aspects of the movement of many animal groups are their sudden coherent changes in direction. Recent observations of locusts and starlings have shown that this directional switching is an intrinsic property of their motion. Similar direction switches are seen in self-propelled particle and othe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yates CA,Erban R,Escudero C,Couzin ID,Buhl J,Kevrekidis IG,Maini PK,Sumpter DJ

更新日期：2009-04-07 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:A number of rare copy number variants (CNVs), including both deletions and duplications, have been associated with developmental disorders, including schizophrenia, autism, intellectual disability, and epilepsy. Pathogenicity may derive from dosage sensitivity of one or more genes contained within the CNV locus. To un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLysaght A,Makino T,Grayton HM,Tropeano M,Mitchell KJ,Vassos E,Collier DA

更新日期：2014-01-07 00:00:00

abstract：:Spectral methods are of fundamental importance in statistics and machine learning, because they underlie algorithms from classical principal components analysis to more recent approaches that exploit manifold structure. In most cases, the core technical problem can be reduced to computing a low-rank approximation to a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belabbas MA,Wolfe PJ

更新日期：2009-01-13 00:00:00

abstract：:Secretion of inflammatory mediators by rat mast cells (line RBL-2H3) was earlier shown to be inhibited upon clustering a membrane glycoprotein by monoclonal antibody G63. This glycoprotein, named mast cell function-associated antigen (MAFA), was also shown to interfere with the coupling cascade of the type 1 Fc epsilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guthmann MD,Tal M,Pecht I

更新日期：1995-09-26 00:00:00

abstract：:Protein kinase A (PKA) is activated during sympathetic stimulation of the heart and phosphorylates key proteins involved in cardiac Ca(2+) handling, including the L-type Ca(2+) channel (Ca(V)1.2) and phospholamban (PLN). This results in acceleration and amplification of the beat-to-beat changes in cytosolic Ca(2+) in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BW,Brunet S,Gilbert ML,Nichols CB,Su T,Westenbroek RE,Scott JD,Catterall WA,McKnight GS

更新日期：2012-10-16 00:00:00

abstract：:After the start of transcription, the 5' ends of eukaryotic mRNA molecules are modified by the addition of a guanylyl residue to form a cap structure, G(5')ppp(5')N. The guanylyltransferase (GTP:mRNA guanylyltransferase, EC 2.7.7.50) reaction responsible for cap formation usually proceeds via a covalent enzyme-GMP int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahola T,Kääriäinen L

更新日期：1995-01-17 00:00:00

abstract：:Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflammation, emphysema, and fibrosis in the lungs of SP-D (-/-) mice. Although lung morphology was unperturbed during the first 2 weeks of life, airspace enlargement was observed by 3 weeks and progressed with advancing age. Inflammation consist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wert SE,Yoshida M,LeVine AM,Ikegami M,Jones T,Ross GF,Fisher JH,Korfhagen TR,Whitsett JA

更新日期：2000-05-23 00:00:00

abstract：:The bacterial pathogen Vibrio parahaemolyticus utilizes a type III secretion system to cause death of host cells within hours of infection. We report that cell death is completely independent of apoptosis and occurs by a mechanism in which injection of multiple type III effectors causes induction of autophagy, cell ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdette DL,Yarbrough ML,Orvedahl A,Gilpin CJ,Orth K

更新日期：2008-08-26 00:00:00

abstract：:Cells in the brain act as components of extended networks. Therefore, to understand neurobiological processes in a physiological context, it is essential to study them in vivo. Super-resolution microscopy has spatial resolution beyond the diffraction limit, thus promising to provide structural and functional insights ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turcotte R,Liang Y,Tanimoto M,Zhang Q,Li Z,Koyama M,Betzig E,Ji N

更新日期：2019-05-07 00:00:00

abstract：:At each stage of infection, the major coat protein of coliphage M13 binds to the E. coli cytoplasmic membrane with its antigenic site exposed to the cell exterior [Wickner, W. (1975) Proc. Nat. Acad. Sci. USA 72, 4749-4753]. This antigenic site is now shown to be at the amino-terminus of the protein. The amino-terminu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner W

更新日期：1976-04-01 00:00:00

abstract：:The sessile plants have evolved a large number of receptor-like kinases (RLKs) and receptor-like cytoplasmic kinases (RLCKs) to modulate diverse biological processes, including plant innate immunity. Phosphorylation of the RLK/RLCK complex constitutes an essential step to initiate immune signaling. Two Arabidopsis pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin W,Li B,Lu D,Chen S,Zhu N,He P,Shan L

更新日期：2014-03-04 00:00:00

abstract：:One goal of regenerative medicine is to repair damaged tissue. This requires not only generating new cells of the proper phenotype, but also selecting for those that properly integrate into sites of injury. In our laboratory we are using a cell-migration-based in vivo selection system to generate antibodies that induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han KH,Arlian BM,Macauley MS,Paulson JC,Lerner RA

更新日期：2018-01-16 00:00:00

abstract：:Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam S,Buettner R,Turkson J,Kim D,Cheng JQ,Muehlbeyer S,Hippe F,Vatter S,Merz KH,Eisenbrand G,Jove R

更新日期：2005-04-26 00:00:00

abstract：:A discrepancy is explored regarding the spin exchange integral estimated from magnetic field effects on recombination of the bacteriochlorophyll dimer cation (Bchl)(2)+ and the bacteriopheophytin anion Bph(-) and the measured electron transfer rate between Bph and electronically excited (Bchl)(2). In one explanation c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberkorn R,Michel-Beyerle ME,Marcus RA

更新日期：1979-09-01 00:00:00

abstract：:The interaction of human high density lipoproteins (HDL) with isolated human monocytes from control and Tangier patients was studied in tissue culture experiments. It was observed that normal monocytes, similar to mouse peritoneal macrophages, bind HDL to a cell surface receptor, internalize the bound HDL particles, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmitz G,Assmann G,Robenek H,Brennhausen B

更新日期：1985-09-01 00:00:00

abstract：:Opitz syndrome (OS) is a genetically heterogeneous disorder characterized by defects of the ventral midline, including hypertelorism, cleft lip and palate, heart defects, and mental retardation. We recently identified the gene responsible for X-linked OS. The ubiquitously expressed gene product, MID1, is a member of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweiger S,Foerster J,Lehmann T,Suckow V,Muller YA,Walter G,Davies T,Porter H,van Bokhoven H,Lunt PW,Traub P,Ropers HH

更新日期：1999-03-16 00:00:00