Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.

abstract：:There are approximately 350 non-odorant G protein-coupled receptors (GPCRs) encoded by the human genome, many of which are predicted to be potential therapeutic targets, but there are only two structures available to represent the whole of the family. We hypothesized that improving the detergent stability of these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serrano-Vega MJ,Magnani F,Shibata Y,Tate CG

更新日期：2008-01-22 00:00:00

abstract：:The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic home...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamitina T,Huang CG,Strange K

更新日期：2006-08-08 00:00:00

abstract：:The human beta-globin locus control region (LCR) consists of four erythroid-specific DNaseI hypersensitive sites (HSs) at the 5' end of the beta-globin cluster. The LCR functions over a long distance on chromosome 11 to regulate transcription and replication of the beta-globin genes. To determine whether the HSs funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bresnick EH,Tze L

更新日期：1997-04-29 00:00:00

abstract：:The levels of c-myc, c-fos, and JE mRNAs accumulate in a biphasic pattern following infection of quiescent BALB/c 3T3 mouse cells with polyomavirus. Maximal levels of c-myc and c-fos mRNAs were seen within 1 hr and were nearly undetectable at 6 hr after infection. At 12 hr after infection mRNA levels were again maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zullo J,Stiles CD,Garcea RL

更新日期：1987-03-01 00:00:00

abstract：:It has been widely reported that intrinsic brain activity, in a variety of animals including humans, is spatiotemporally structured. Specifically, propagated slow activity has been repeatedly demonstrated in animals. In human resting-state fMRI, spontaneous activity has been understood predominantly in terms of zero-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra A,Snyder AZ,Blazey T,Raichle ME

更新日期：2015-04-28 00:00:00

abstract：:The temporal distribution of the major extinctions over the past 250 million years has been investigated statistically using various forms of time series analysis. The analyzed record is based on variation in extinction intensity for fossil families of marine vertebrates, invertebrates, and protozoans and contains 12 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raup DM,Sepkoski JJ Jr

更新日期：1984-02-01 00:00:00

abstract：:Williams-Beuren syndrome (also known as Williams syndrome) is caused by a deletion of a 1.55- to 1.84-megabase region from chromosome band 7q11.23. GTF2IRD1 and GTF2I, located within this critical region, encode proteins of the TFII-I family with multiple helix-loop-helix domains known as I repeats. In the present wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makeyev AV,Erdenechimeg L,Mungunsukh O,Roth JJ,Enkhmandakh B,Ruddle FH,Bayarsaihan D

更新日期：2004-07-27 00:00:00

abstract：:Evolutionary transitions in individuality (ETIs) underlie the watershed events in the history of life on Earth, including the origins of cells, eukaryotes, plants, animals, and fungi. Each of these events constitutes an increase in the level of complexity, as groups of individuals become individuals in their own right...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herron MD,Hackett JD,Aylward FO,Michod RE

更新日期：2009-03-03 00:00:00

abstract：:The search for technosignatures from hypothetical galactic civilizations is going through a new phase of intense activity. For the first time, a significant fraction of the vast search space is expected to be sampled in the foreseeable future, potentially bringing informative data about the abundance of detectable ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grimaldi C,Marcy GW

更新日期：2018-10-16 00:00:00

abstract：:In 1989, populations of North American gypsy moth, Lymantria dispar, in seven contiguous northeastern states were severely reduced by a fungal pathogen. Based on morphology, development, and pathology, this organism appeared to be Entomophaga maimaiga. We have now used allozyme and restriction fragment length polymorp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hajek AE,Humber RA,Elkinton JS,May B,Walsh SR,Silver JC

更新日期：1990-09-01 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:Sensitization of defensive gill and siphon withdrawal reflexes in Aplysia results, in part, from presynaptic facilitation of transmitter release from mechanoreceptor sensory neurons that innervate the siphon skin and synapse with interneurons and motor neurons. Presynaptic facilitation also can be elicited by applicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochner B,Klein M,Schacher S,Kandel ER

更新日期：1986-11-01 00:00:00

abstract：:Underacetylation of histone H4 is thought to be involved in the molecular mechanism of mammalian X chromosome inactivation, which is an important model system for large-scale genetic control in eukaryotes. However, it has not been established whether histone underacetylation plays a critical role in the multistep inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakefield MJ,Keohane AM,Turner BM,Graves JA

更新日期：1997-09-02 00:00:00

abstract：:Nucleotide variations, including SNPs, in the coding regions of disease genes are important targets for RNAi treatment, which is a promising medical treatment for intractable diseases such as triplet repeat diseases. However, the identification of such nucleotide variations and the design of siRNAs conferring disease ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi M,Watanabe S,Murata M,Furuya H,Kanazawa I,Wada K,Hohjoh H

更新日期：2010-12-14 00:00:00

abstract：:Reestablishment of vascular homeostasis following ex vivo preservation is a critical determinant of successful organ transplantation. Because the nitric oxide (NO) pathway modulates pulmonary vascular tone and leukocyte/endothelial interactions, we hypothesized that reactive oxygen intermediates would lead to decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinsky DJ,Naka Y,Chowdhury NC,Liao H,Oz MC,Michler RE,Kubaszewski E,Malinski T,Stern DM

更新日期：1994-12-06 00:00:00

abstract：:During the process of fertilization in mammals, sperm bind in a relatively species-specific manner to the zona pellucida (ZP) of ovulated eggs. ZP3, a glycoprotein found in the mouse egg zona pellucida, serves as receptor for sperm during gamete adhesion. We report here that a Mr 56,000 protein found on mouse sperm ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleil JD,Wassarman PM

更新日期：1990-07-01 00:00:00

abstract：:The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation domain (TAD) of p53,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon JC,Lee CW,Arai M,Martinez-Yamout MA,Dyson HJ,Wright PE

更新日期：2009-04-21 00:00:00

abstract：:Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period for the acquisition of normal face processing. Here, we consider a more parsimonious account according to which deficits in configural analysis result from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogelsang L,Gilad-Gutnick S,Ehrenberg E,Yonas A,Diamond S,Held R,Sinha P

更新日期：2018-10-30 00:00:00

abstract：:Cellular metabolism alters patterns of gene expression through a variety of mechanisms, including alterations in histone modifications and transcription factor activity. Nicotinamide adenine dinucleotide (NAD)-dependent proteins such as poly(ADP ribose) polymerases (PARPs) and sirtuin deacetylases play important roles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang J,Zhang B,Heath H,Galjart N,Wang X,Milbrandt J

更新日期：2010-12-14 00:00:00

abstract：:Prion protein consists of an ensemble of glycosylated variants or glycoforms. The enzymes that direct oligosaccharide processing, and hence control the glycan profile for any given glycoprotein, are often exquisitely sensitive to other events taking place within the cell in which the glycoprotein is expressed. Alterat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudd PM,Endo T,Colominas C,Groth D,Wheeler SF,Harvey DJ,Wormald MR,Serban H,Prusiner SB,Kobata A,Dwek RA

更新日期：1999-11-09 00:00:00

abstract：:We have assessed whether retinoic acid (RA) comes from local sources or is available widely to activate gene expression in embryos. We used an RA-responsive indicator cell line, L-C2A5, to localize RA sources. In these cells, an RA-sensitive promoter/lacZ reporter construct used previously by us to produce indicator t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colbert MC,Linney E,LaMantia AS

更新日期：1993-07-15 00:00:00

abstract：:Calmodulin, a wide-spread eukaryotic Ca2+-binding protein, was phosphorylated at its tyrosine residues in Rous sarcoma virus (RSV)-transformed chicken and rat cells but not in normal chicken embryo fibroblasts. In contrast, serine and threonine phosphorylation of calmodulin was found to occur in both normal and virus-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukami Y,Nakamura T,Nakayama A,Kanehisa T

更新日期：1986-06-01 00:00:00

abstract：:Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed latent and active forms of collagenase (MMP-1, EC 3.4.24.7), 72-kDa gelatinase A (MMP-2, EC 3.4.24.24), and 92-kDa gelatinase B (MMP-9, EC 3.4.24.35). These protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbaix E,Donnez J,Courtoy PJ,Eeckhout Y

更新日期：1992-12-15 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7 encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi membrane. A Golgi vesicle enriched fraction of Saccharomyces c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berninsone P,Hwang HY,Zemtseva I,Horvitz HR,Hirschberg CB

更新日期：2001-03-27 00:00:00

abstract：:In epidemiological studies, both positive and negative correlations have been found between cardiovascular disease and mortality and the presence of several inorganic ions in the drinking water. In an attempt to resolve this apparent disagreement, we exposed White Carneau pigeons to drinking water containing calcium (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revis NW,Zinsmeister AR,Bull R

更新日期：1981-10-01 00:00:00

abstract：:The murine T-cell surface molecules Lyt-2 and L3T4 play a role in the activation of antigen-specific T cells. The currently accepted model for the function of these molecules proposes that Lyt-2 and L3T4 increase the overall avidity of the interaction between the T-cell antigen receptor and antigen in association with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fazekas de St Groth B,Gallagher PF,Miller JF

更新日期：1986-04-01 00:00:00

abstract：:The tumor promoter phorbol 12-myristate 13-acetate (PMA) induces characteristic reversible changes of cell shape in certain fibroblastic lines: motile lamellas are transformed into noncontractile narrow processes; simultaneously, the actin microfilament network of lamellas is locally disorganized. This reaction to PMA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bershadsky AD,Ivanova OY,Lyass LA,Pletyushkina OY,Vasiliev JM,Gelfand IM

更新日期：1990-03-01 00:00:00

abstract：:Recent theory suggests that animals should switch facultatively among canonical movement modes as a complex function of internal state, landscape characteristics, motion capacity, and navigational capacity. We tested the generality of this paradigm for free-ranging elk (Cervus elaphus) over 5 orders of magnitude in ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fryxell JM,Hazell M,Börger L,Dalziel BD,Haydon DT,Morales JM,McIntosh T,Rosatte RC

更新日期：2008-12-09 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00