Stochastic model of protein-protein interaction: why signaling proteins need to be colocalized.

abstract：:Habituation is a form of simple memory that suppresses neural activity in response to repeated, neutral stimuli. This process is critical in helping organisms guide attention toward the most salient and novel features in the environment. Here, we follow known circuit mechanisms in the fruit fly olfactory system to der...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen Y,Dasgupta S,Navlakha S

更新日期：2020-06-02 00:00:00

abstract：:Gene-environment interactions are important determinants of cancer risk. Traditionally, gene-environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we demonstrate that a disti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JD,Davis BJ,Cai SL,Barrett JC,Conti CJ,Walker CL

更新日期：2005-06-14 00:00:00

abstract：:The effects of epinephrine (as low as 0.1 muM) on guanosine 3':5'-cyclic monophosphate (cGMP) and adenosine 3':5'-cyclic monophosphate (cAMP) in isolated fat cells were examined. Epinephrine increased both cGMP and cAMP levels, with the elevation of cAMP preceding the rise of cGMP. Maximal elevation was obtained with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakawa T,Ruiz J,Ho RJ

更新日期：1978-06-01 00:00:00

abstract：:Copper is an essential micronutrient that plays a central role for a broad range of biological processes. Although there is compelling evidence that the intracellular milieu does not contain any free copper ions, the rapid kinetics of copper uptake and release suggests the presence of a labile intracellular copper poo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang L,McRae R,Henary MM,Patel R,Lai B,Vogt S,Fahrni CJ

更新日期：2005-08-09 00:00:00

abstract：:Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid compositi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmer R,van der Ploeg K,Ron D

更新日期：2013-03-19 00:00:00

abstract：:Citizenship endows legal protections and is associated with economic and social gains for immigrants and their communities. In the United States, however, naturalization rates are relatively low. Yet we lack reliable knowledge as to what constrains immigrants from applying. Drawing on data from a public/private natura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hainmueller J,Lawrence D,Gest J,Hotard M,Koslowski R,Laitin DD

更新日期：2018-01-30 00:00:00

abstract：:Although it is accepted that regulatory T cells (T regs) contribute to cancer progression, most studies in the field consider nonantigen-specific suppression. Here, we show the presence of tumor antigen-specific CD4(+) T regs in the blood of patients with metastatic melanoma. These CD4(+) T regs recognize a broad rang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vence L,Palucka AK,Fay JW,Ito T,Liu YJ,Banchereau J,Ueno H

更新日期：2007-12-26 00:00:00

abstract：:Human capabilities in manipulating many different tools with dexterity suggest modular neural organization at functional levels, but anatomical modularity underlying the capabilities has yet to be demonstrated. Although modularity in phylogenetically older parts of the cerebellum is well known, comparable modularity i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imamizu H,Kuroda T,Miyauchi S,Yoshioka T,Kawato M

更新日期：2003-04-29 00:00:00

abstract：:The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burakoff SJ,Germain RN,Dorf ME,Benacerrah B

更新日期：1976-02-01 00:00:00

abstract：:Some cells from cultured embryonic mouse hypothalamus were found to express aromatic-L-amino acid decarboxylase (EC 4.1.1.28) activity and serotonin uptake and storage. These neuron-like cells differed from serotoninergic neurons in cultured embryonic mouse brain stem since they did not contain tryptophan hydroxylase....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Vitry F,Hamon M,Catelon J,Dubois M,Thibault J

更新日期：1986-11-01 00:00:00

abstract：:Theoretical models suggest that social networks influence the evolution of cooperation, but to date there have been few experimental studies. Observational data suggest that a wide variety of behaviors may spread in human social networks, but subjects in such studies can choose to befriend people with similar behavior...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH,Christakis NA

更新日期：2010-03-23 00:00:00

abstract：:The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama Y,Sakaguchi M,Terabayashi T,Inenaga T,Inoue S,Kobayashi C,Oshima N,Kiyonari H,Nakagata N,Sato Y,Sekiguchi K,Miki H,Araki E,Fujimura S,Tanaka SS,Nishinakamura R

更新日期：2010-05-18 00:00:00

abstract：:The ionophores A23187 and bromolasalocid (Br-X537A) acted synergistically in translocating Ca(2+) from an aqueous into an organic immiscible phase or in mediating Ca(2+) transport across the organic phase, the effects obtained in the simultaneous presence of both ionophores being greater than those expected from a sum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deleers M,Gelbcke M,Malaisse WJ

更新日期：1981-01-01 00:00:00

abstract：:The T-box transcription factor TBX5 plays essential roles in cardiac and limb development. Various mutations in the TBX5 gene have been identified in patients with Holt-Oram syndrome, which is characterized by congenital defects in the heart and upper extremities. In this study, we identified a WW-domain-containing tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami M,Nakagawa M,Olson EN,Nakagawa O

更新日期：2005-12-13 00:00:00

abstract：:The bacterial pathogen Vibrio parahaemolyticus utilizes a type III secretion system to cause death of host cells within hours of infection. We report that cell death is completely independent of apoptosis and occurs by a mechanism in which injection of multiple type III effectors causes induction of autophagy, cell ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdette DL,Yarbrough ML,Orvedahl A,Gilpin CJ,Orth K

更新日期：2008-08-26 00:00:00

abstract：:The phosphorylation and dephosphorylation of the dihydropyridine-sensitive Ca2+ channel was studied in transverse-tubule membranes isolated from rabbit skeletal muscle. Exposure of these membranes to either the cAMP-dependent protein kinase or a Ca2+/calmodulin-dependent protein kinase resulted in a rapid phosphorylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosey MM,Borsotto M,Lazdunski M

更新日期：1986-06-01 00:00:00

abstract：:Both laboratory and field data suggest that people punish noncooperators even in one-shot interactions. Although such "altruistic punishment" may explain the high levels of cooperation in human societies, it creates an evolutionary puzzle: existing models suggest that altruistic cooperation among nonrelatives is evolu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Gintis H,Bowles S,Richerson PJ

更新日期：2003-03-18 00:00:00

abstract：:We have synthesized two sets of 15-base-long oligodeoxyribonucleotides corresponding to all possible coding sequences for a small portion of human beta 2-microglobulin. Labeled oligonucleotides were used as hybridization probes to screen bacterial clones containing cDNA sequences primed with oligo(dT) and inserted int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suggs SV,Wallace RB,Hirose T,Kawashima EH,Itakura K

更新日期：1981-11-01 00:00:00

abstract：:We report two instances of selective accumulation of herpes simplex 1 RNA transcripts in different compartments of infected HEp-2 cells. In the first, transcripts derived from about 50% of the viral DNA accumulated in the nuclei of cells 8 hr after infection. However, only 40-42% of the DNA was represented in transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozak M,Roizman B

更新日期：1974-11-01 00:00:00

abstract：:The history of southern Africa involved interactions between indigenous hunter-gatherers and a range of populations that moved into the region. Here we use genome-wide genetic data to show that there are at least two admixture events in the history of Khoisan populations (southern African hunter-gatherers and pastoral...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickrell JK,Patterson N,Loh PR,Lipson M,Berger B,Stoneking M,Pakendorf B,Reich D

更新日期：2014-02-18 00:00:00

abstract：:We report here the identification of a pollen-specific gene from Zea mays that contains multiple Ser-(Pro)n repeats, the motif found in the cell wall-associated extensins. Sequence analysis reveals that the encoded protein has a putative globular domain at the N terminus and an extensin-like domain at the C terminus. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubinstein AL,Broadwater AH,Lowrey KB,Bedinger PA

更新日期：1995-04-11 00:00:00

abstract：:Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quirarte GL,Roozendaal B,McGaugh JL

更新日期：1997-12-09 00:00:00

abstract：:Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kringelbach ML,Cruzat J,Cabral J,Knudsen GM,Carhart-Harris R,Whybrow PC,Logothetis NK,Deco G

更新日期：2020-04-28 00:00:00

abstract：:The Bill and Melinda Gates Foundation supports an ambitious portfolio of novel vaccines, drug regimens, and diagnostic tools for tuberculosis (TB). We elicited the expected efficacies and improvements of the novel interventions in discussions with the foundations managing their development. Using an age-structured mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abu-Raddad LJ,Sabatelli L,Achterberg JT,Sugimoto JD,Longini IM Jr,Dye C,Halloran ME

更新日期：2009-08-18 00:00:00

abstract：:Two regions of human thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSHR) (residues 12-44 and 308-364) were selected on the basis that they exhibit no sequence resemblance to luteinizing hormone/chorionic gonadotropin receptor. Five synthetic overlapping peptides (12-30, 24-44, 308-328, 324-344, and 339-364)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atassi MZ,Manshouri T,Sakata S

更新日期：1991-05-01 00:00:00

abstract：:The genomic basis of primate phenotypic uniqueness remains obscure, despite increasing genome and transcriptome sequence data availability. Although factors such as segmental duplications and positive selection have received much attention as potential drivers of primate phenotypes, single-copy primate-specific genes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tay SK,Blythe J,Lipovich L

更新日期：2009-07-21 00:00:00

abstract：:A broad program of freezing species in threatened ecospheres could preserve biodiversity for eventual use by future generations. Sampling without studying can lower costs dramatically. Local labor can do most of the gathering. Plausible costs of collecting and cryogenically suspending the tropical rain forest species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benford G

更新日期：1992-11-15 00:00:00

abstract：:Charge transfer at metallo-molecular interfaces may be used to design multifunctional hybrids with an emergent magnetization that may offer an eco-friendly and tunable alternative to conventional magnets and devices. Here, we investigate the origin of the magnetism arising at these interfaces by using different techni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Al Ma'Mari F,Rogers M,Alghamdi S,Moorsom T,Lee S,Prokscha T,Luetkens H,Valvidares M,Teobaldi G,Flokstra M,Stewart R,Gargiani P,Ali M,Burnell G,Hickey BJ,Cespedes O

更新日期：2017-05-30 00:00:00

abstract：:We have shown that the silk fibroin gene from Bombyx mori is faithfully transcribed in an in vitro transcription system of the HeLa cell extract prepared by the method of Manley et al. [Manley, J. L., Fire, A., Cano, A., Sharp, P. A. & Gefter, M. L. (1980) Proc. Natl. Acad. Sci. USA 77, 3855-3859]. Using this system a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsujimoto Y,Hirose S,Tsuda M,Suzuki Y

更新日期：1981-08-01 00:00:00

abstract：:From the types of ring chromosomes induced in x-irradiated Chinese hamster ovary (CHO) cells, we deduce the existence of switches in the polarity of chromosomal DNA; if there is a continuous DNA double helix along the full length of the chromosome then the polarity switches imply 3'-3' and 5'-5' phosphodiester linkage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff S,Lindsley DL,Peacock WJ

更新日期：1976-03-01 00:00:00