Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance.

abstract：:Invasive organisms pose a global threat and are exceptionally difficult to eradicate after they become abundant in their new habitats. We report a successful multitactic strategy for combating the pink bollworm (Pectinophora gossypiella), one of the world's most invasive pests. A coordinated program in the southwester...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tabashnik BE,Liesner LR,Ellsworth PC,Unnithan GC,Fabrick JA,Naranjo SE,Li X,Dennehy TJ,Antilla L,Staten RT,Carrière Y

更新日期：2021-01-05 00:00:00

abstract：:Citrullinemia is an inborn error of metabolism due to deficiency of the urea cycle enzyme, argininosuccinate synthetase [L-citrulline:L-aspartate ligase (AMP-forming), EC 6.3.4.5]. The disease was first described in humans but was recently reported in dairy cattle in Australia. Here we report the nucleotide sequence o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennis JA,Healy PJ,Beaudet AL,O'Brien WE

更新日期：1989-10-01 00:00:00

abstract：:The perceptual quality of odors usually is robust to variability in concentration. However, maps of neural activation across the olfactory bulb glomerular layer are not stable in this respect; rather, glomerular odor representations both broaden and intensify as odorant concentrations are increased. The relative level...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleland TA,Johnson BA,Leon M,Linster C

更新日期：2007-02-06 00:00:00

abstract：:The term quantum turbulence denotes the turbulent motion of quantum fluids, systems such as superfluid helium and atomic Bose-Einstein condensates, which are characterized by quantized vorticity, superfluidity, and, at finite temperatures, two-fluid behavior. This article introduces their basic properties, describes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenghi CF,Skrbek L,Sreenivasan KR

更新日期：2014-03-25 00:00:00

abstract：:Networks are widely used in the biological, physical, and social sciences as a concise mathematical representation of the topology of systems of interacting components. Understanding the structure of these networks is one of the outstanding challenges in the study of complex systems. Here we describe a general techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman ME,Leicht EA

更新日期：2007-06-05 00:00:00

abstract：:Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luft CDB,Zioga I,Thompson NM,Banissy MJ,Bhattacharya J

更新日期：2018-12-26 00:00:00

abstract：:The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Wang M,Ririe TO,Fernandes JS,Sternberg PW

更新日期：2005-04-05 00:00:00

abstract：:We and others have reported that the vast majority of virus-producing CD4(+) T cells during the acute infection of rhesus macaques with simian immunodeficiency virus (SIV) or CXCR4 (X4)-using simian/human immunodeficiency viruses (SHIVs) exhibited a nonactivated phenotype. These findings have been extended to show tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishimura Y,Sadjadpour R,Mattapallil JJ,Igarashi T,Lee W,Buckler-White A,Roederer M,Chun TW,Martin MA

更新日期：2009-05-12 00:00:00

abstract：:Absorbance changes of C-550 and cytochrome b(559), and fluorescence-yield changes were measured during irradiation of chloroplasts at -196 degrees . The photo-reduction of C-550 proceeded more rapidly than the photo-oxidation of cytochrome b(559), and the fluorescence-yield change had similar kinetics to the cytochrom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler WL

更新日期：1972-11-01 00:00:00

abstract：:Myocytes in the atria contain a prohormone that gives rise to atrial natriuretic peptides (ANP), which have intrinsic hemodynamic regulatory activity. Little is known about mechanisms regulating ANP release. In rats with indwelling catheters, acute blood volume expansion with 5% (wt/vol) dextrose increases the amount ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Haass M,Dave JR,Zukowska-Grojec Z

更新日期：1987-01-01 00:00:00

abstract：:To generate antibodies with different effector functions, B cells undergo Immunoglobulin Heavy Chain (IgH) class switch recombination (CSR). The ligation step of CSR is usually mediated by the classical nonhomologous end-joining (cNHEJ) pathway. In cNHEJ-deficient cells, a remarkable ∼25% of CSR can be achieved by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang XS,Zhao J,Wu-Baer F,Shao Z,Lee BJ,Cupo OM,Rabadan R,Gautier J,Baer R,Zha S

更新日期：2020-10-13 00:00:00

abstract：:Synthetic pheomelanins from enzymic oxidation of the 3,4-dihydroxyphenylalanine (dopa) derivative 5-S-cysteinyldopa have been examined by ESR spectroscopy. These alkalisoluble polymers contain a novel kind of free radical that is spectroscopically distinct from that found in eumelanins. Delocalization of the unpaired ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sealy RC,Hyde JS,Felix CC,Menon IA,Prota G,Swartz HM,Persad S,Haberman HF

更新日期：1982-05-01 00:00:00

abstract：:The first essential step in protein photoreception is the capture and storage of energy from a photon. We have recently identified and isolated, from the purple photoautotrophic bacterium, Ectothiorhodospira halophila, a 13,000-dalton photoactive yellow protein (PYP) that has a photocycle with kinetics similar to sens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McRee DE,Tainer JA,Meyer TE,Van Beeumen J,Cusanovich MA,Getzoff ED

更新日期：1989-09-01 00:00:00

abstract：:The human papillomavirus E7 protein is phosphorylated at the two serines in positions 31/32, which are part of a consensus sequence for casein kinase II (CKII). In this study, we have investigated the effect of CKII phosphorylation site mutations, all of which lead to unphosphorylated E7 proteins. The replacement of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Firzlaff JM,Lüscher B,Eisenman RN

更新日期：1991-06-15 00:00:00

abstract：:Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Kang K,Mehl IR,Nofsinger R,Alaynick WA,Chong LW,Rosenfeld JM,Evans RM

更新日期：2006-02-14 00:00:00

abstract：:Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perego M,Hoch JA

更新日期：1996-02-20 00:00:00

abstract：:Sensitive optical signal detection can often be confounded by the presence of a significant background, and, as such, predetection background suppression is substantively important for weak signal detection. In this paper, we present a novel optical structure design, termed surface-wave-enabled darkfield aperture (SWE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng G,Cui X,Yang C

更新日期：2010-05-18 00:00:00

abstract：:In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Mishra S,Sakthivel R,Rojas M,Ranjan R,Sullivan WJ Jr,Fontoura BM,Ménard R,Dever TE,Nussenzweig V

更新日期：2012-03-06 00:00:00

abstract：:Cystic fibrosis (CF) is a recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The most common symptoms include progressive lung disease and chronic digestive conditions. CF is the first human genetic disease to benefit from having five different species of animal models. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim K,Lane EA,Saftien A,Wang H,Xu Y,Wirtz-Peitz F,Perrimon N

更新日期：2020-05-12 00:00:00

abstract：:Two molecular forms of pyrophosphate-dependent phosphofructokinase (PP(i)-PFK; pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase; EC 2.7.1.90) have been found whose activity depends upon association and dissociation characteristics regulated by fructose 2,6-bisphosphate (Fru-2,6-P(2)). PP(i)-PFK was purified 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MX,Smyth DA,Black CC

更新日期：1984-08-01 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:Multiple paleoclimate proxies are required for robust assessment of past hydroclimatic conditions. Currently, estimates of drought variability over the past several thousand years are based largely on tree-ring records. We produced a 1,500-y record of winter precipitation in the Pacific Northwest using a physical mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman BA,Abbott MB,Mann ME,Stansell ND,Finney BP

更新日期：2012-07-17 00:00:00

abstract：:The c-ras family is a set of c-onc genes that are highly conserved in vertebrates. The genes in this family are homologous to the transforming genes of Harvey and Kirsten murine sarcoma viruses (v-Ha-ras and v-Ki-ras, respectively). Using an in situ molecular hybridization method, we detected three sites on the human ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jhanwar SC,Neel BG,Hayward WS,Chaganti RS

更新日期：1983-08-01 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:We identified the phosphatidylinositol transfer protein (PITP) as being responsible for a powerful latent, nucleotide-independent, Golgi-vesiculating activity that is present in the cytosol but is only manifested as an uncontrolled activity in a cytosolic protein subfraction, in which it is separated from regulatory c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon JP,Morimoto T,Bankaitis VA,Gottlieb TA,Ivanov IE,Adesnik M,Sabatini DD

更新日期：1998-09-15 00:00:00

abstract：:Treatment of the third component of human complement (C3) with methylamine results in a loss of hemolytic function and the appearance of a thiol group. Studies with [14C]methylamine have indicatd a stoichiometric and covalent reaction with the native protein. Hydrazine-inactivated C3 and C3b prepared with bovine tryps...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tack BF,Harrison RA,Janatova J,Thomas ML,Prahl JW

更新日期：1980-10-01 00:00:00

abstract：:The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines: the bacterial flagellum that enables cells to propel themselves through liquid and across hydrated surfaces, and the injectisome that delivers pathogenic effector proteins into eukaryotic host cells. Although the flagellum and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wee DH,Hughes KT

更新日期：2015-03-31 00:00:00

abstract：:Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

更新日期：2000-01-04 00:00:00

abstract：:Cajal-Retzius (CR) cells are early-generated transient neurons and are important in the regulation of cortical neuronal migration and cortical laminar formation. Molecular entities characterizing the CR cell identity, however, remain largely elusive. We purified mouse cortical CR cells expressing GFP to homogeneity by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki H,Sekiguchi M,Takamatsu M,Tanabe Y,Nakanishi S

更新日期：2004-10-05 00:00:00

abstract：:A striking and widespread observation is that higher-order folding for many RNAs is very slow, often requiring minutes. In some cases, slow folding reflects the need to disrupt stable, but incorrect, interactions. However, a molecular explanation for slow folding in most RNAs is unknown. The specificity domain of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mortimer SA,Weeks KM

更新日期：2009-09-15 00:00:00