Molecular definition of bovine argininosuccinate synthetase deficiency.

abstract：:DNA sequence motifs that affect RNA polymerase transcription elongation are well studied in prokaryotic organisms and contribute directly to regulation of gene expression. Despite significant work on the regulation of eukaryotic transcription, the effect of DNA template sequence on RNA polymerase I (Pol I) transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarke AM,Engel KL,Giles KE,Petit CM,Schneider DA

更新日期：2018-12-11 00:00:00

abstract：:The 1,25-dihydroxyvitamin D3 [1,25-(OH)2vitamin D3] analog KH1060 exerts very potent effects on cell proliferation and cell differentiation via the vitamin D receptor (VDR). However, the activities of KH1060 are not associated with an increased affinity for the VDR. We now show that increased stabilization of the VDR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Bemd GC,Pols HA,Birkenhäger JC,van Leeuwen JP

更新日期：1996-10-01 00:00:00

abstract：:Immobilization antigens of stock 51 of Paramecium tetraurelia were subjected to electrophoresis in NaDodSO(4)/polyacrylamide gels. Type A is estimated to have a molecular size of 300,000 daltons; H is estimated to be 288,000, D to be 280,000, E to be 270,000, B to be 253,000, and C to be 250,000. Poly(A)(+)RNAs have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preer JR,Preer LB,Rudman BM

更新日期：1981-11-01 00:00:00

abstract：:Intense proteolysis of cytoskeletal proteins occurs in brain within minutes of transient ischemia, possibly because of the activation of calcium-sensitive proteases (calpains). This proteolytic event precedes overt signs of neuronal degeneration, is most pronounced in regions of selective neuronal vulnerability, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee KS,Frank S,Vanderklish P,Arai A,Lynch G

更新日期：1991-08-15 00:00:00

abstract：:Explanted mouse blastocysts were microinjected in the blastocoel cavity with simian virus 40 (SV40) viral DNA. After surgical transfer to the uteri of pseudopregnant surrogate mothers, approximately 40% of the blastocysts developed to term and became healthy adults without apparent tumors at 1 year of age. Molecular h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaenisch R,Mintz B

更新日期：1974-04-01 00:00:00

abstract：:A discussion of the range of applicability of Forster long-range energy transfer in the determination of macromolecular dimensions and conformational dynamics is given. Emphasis is laid on the effect of restrictions in the orientational freedom of donor and acceptor and on the importance of the orientational averaging...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dale RE,Eisinger J

更新日期：1976-02-01 00:00:00

abstract：:An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blenis J

更新日期：1993-07-01 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of the majority of patients with atopic dermatitis (AD), and its presence increases disease severity. Adhesion of S. aureus to corneocytes in the stratum corneum is a key initial event in colonization, but the bacterial and host factors contributing to this process have not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towell AM,Feuillie C,Vitry P,Da Costa TM,Mathelié-Guinlet M,Kezic S,Fleury OM,McAleer MA,Dufrêne YF,Irvine AD,Geoghegan JA

更新日期：2021-01-05 00:00:00

abstract：:Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire mutations that impact viral growth. These laboratory-adapted strains of HCMV generally exhibit restricted tropism, produce high levels of cell-free virus, and develop susceptibility to natural killer cells. To permit experimentation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murrell I,Bedford C,Ladell K,Miners KL,Price DA,Tomasec P,Wilkinson GWG,Stanton RJ

更新日期：2017-06-06 00:00:00

abstract：:The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests wou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Broadbent EN,Oliveira PJ,Keller M,Knapp DE,Silva JN

更新日期：2006-08-22 00:00:00

abstract：:Concepts organize the relationship among individual stimuli or events by highlighting shared features. Often, new goals require updating conceptual knowledge to reflect relationships based on different goal-relevant features. Here, our aim is to determine how hippocampal (HPC) object representations are organized and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack ML,Love BC,Preston AR

更新日期：2016-11-15 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Normal human cells whether embryonic, neonatal, or adult are resistant to experimentally induced tumorigenesis in contrast to rodent or chicken cells. We showed previously that neither transformation with simian virus 40 DNA nor transfection with human mutant HRAS DNA immortalized FS-2 cells (diploid, neonatal human f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Brien W,Stenman G,Sager R

更新日期：1986-11-01 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:A sensitive assay for detection of eukaryotic RNA polymerase II has been developed. This assay depends on the ability of polymerase II to elongate a small RNA primer, oligo(U), hybridized to a single-stranded homopolymeric DNA template, poly(dA). The poly(dA).oligo(U)-dependent RNA polymerase II from calf thymus has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fradkin LG,Leong K,Morrow CD,Berk AJ,Dasgupta A

更新日期：1985-12-01 00:00:00

abstract：:Human IL-10 (hIL-10) modulates critical immune and inflammatory responses by way of interactions with its high- (IL-10R1) and low-affinity (IL-10R2) cell surface receptors. Human cytomegalovirus exploits the IL-10 signaling pathway by expressing a functional viral IL-10 homolog (cmvIL-10), which shares only 27% sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BC,Logsdon NJ,Josephson K,Cook J,Barry PA,Walter MR

更新日期：2002-07-09 00:00:00

abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polis BD,Polis E,Kwong S

更新日期：1979-04-01 00:00:00

abstract：:Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple sclerosis (MS). Currently there are no prognostic biological markers that accurately predict conversion of CIS to clinically definite MS (CDMS). Furthermore, the earliest molecular events in MS are still unknown. We used micro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corvol JC,Pelletier D,Henry RG,Caillier SJ,Wang J,Pappas D,Casazza S,Okuda DT,Hauser SL,Oksenberg JR,Baranzini SE

更新日期：2008-08-19 00:00:00

abstract：:We have used methods that have allowed simultaneous fluorescent staining of intracellular actin together with either myosin, filamin, or tubulin in normal rat kidney fibroblasts in monolayer culture. In the main portions of the cell body, the actin, myosin, and filamin are all present in two structures: in one, the th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Wang K,Singer SJ

更新日期：1977-09-01 00:00:00

abstract：:Two regions of human thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSHR) (residues 12-44 and 308-364) were selected on the basis that they exhibit no sequence resemblance to luteinizing hormone/chorionic gonadotropin receptor. Five synthetic overlapping peptides (12-30, 24-44, 308-328, 324-344, and 339-364)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atassi MZ,Manshouri T,Sakata S

更新日期：1991-05-01 00:00:00

abstract：:Social separation early in life can lead to the development of impaired interpersonal relationships and profound social disorders. However, the underlying cellular and molecular mechanisms involved are largely unknown. Here, we found that isolation of neonatal rats induced glucocorticoid-dependent social dominance ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tada H,Miyazaki T,Takemoto K,Takase K,Jitsuki S,Nakajima W,Koide M,Yamamoto N,Komiya K,Suyama K,Sano A,Taguchi A,Takahashi T

更新日期：2016-11-08 00:00:00

abstract：:Human mammary epithelial cells secrete and express on their cell surfaces complex mucin glycoproteins (Mr greater than 250,000) that are developmentally regulated, tumor-associated, and highly immunogenic. Studies using monoclonal antibodies directed to these glycoproteins suggest that their molecular structures can v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gendler SJ,Burchell JM,Duhig T,Lamport D,White R,Parker M,Taylor-Papadimitriou J

更新日期：1987-09-01 00:00:00

abstract：:Unintended block of HERG K+ channels is a side effect of many common medications and is the most common cause of acquired long QT syndrome associated with increased risk of life-threatening arrhythmias. The molecular mechanism of high-affinity HERG block by structurally diverse compounds has been attributed to pi-stac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Seebohm G,Sanguinetti MC

更新日期：2002-09-17 00:00:00

abstract：:Adult naive T cells, which are at rest in normal conditions, proliferate strongly when transferred to lymphopenic hosts. In neonates, the first mature thymocytes to migrate to the periphery reach a compartment devoid of preexisting T cells. We have extensively analyzed the proliferation rate and phenotype of periphera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Campion A,Bourgeois C,Lambolez F,Martin B,Léaument S,Dautigny N,Tanchot C,Pénit C,Lucas B

更新日期：2002-04-02 00:00:00

abstract：:The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal morphology when inactivated in mice. Remarkably, all seven genes showed corpus callosum defects, inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,Bär S,Minocha S,Chevalier C,Po C,Sanger Mouse Genetics Project.,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,Hérault Y,

更新日期：2017-10-31 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a genetic disorder caused by loss of the protein dystrophin. In humans, DMD has early onset, causes developmental delays, muscle necrosis, loss of ambulation, and death. Current animal models have been challenged by their inability to model the early onset and severity of the disea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes KJ,Rodriguez A,Flatt KM,Ray S,Schuler A,Rodemoyer B,Veerappan V,Cuciarone K,Kullman A,Lim C,Gutta N,Vemuri S,Andriulis V,Niswonger D,Barickman L,Stein W,Singhvi A,Schroeder NE,Vidal-Gadea AG

更新日期：2019-02-26 00:00:00

abstract：:Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2), subsequently processed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kracker S,Imai K,Gardès P,Ochs HD,Fischer A,Durandy AH

更新日期：2010-12-21 00:00:00

abstract：:Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical determinants of membrane excitability in cells throughout the body, incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters CH,Myers ME,Juchno J,Haimbaugh C,Bichraoui H,Du Y,Bankston JR,Walker LA,Proenza C

更新日期：2020-07-28 00:00:00

abstract：:We have grown crystals of a soluble recombinant form of human CD4, a transmembrane glycoprotein found predominantly on the surface of helper T cells. Crystals composed of the entire extracellular portion of CD4 exhibit extensive polymorphism. Of the five crystal types that have been grown, the best diffracts to Bragg ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwong PD,Ryu SE,Hendrickson WA,Axel R,Sweet RM,Folena-Wasserman G,Hensley P,Sweet RW

更新日期：1990-08-01 00:00:00

abstract：:The identities between homogeneous expressions in rank 1 vectors and rank n - 1 covectors in a Grassmann-Cayley algebra of rank n, in which one set occurs multilinearly, are shown to represent a set of dimension-independent identities. The theorem yields an infinite set of nontrivial geometric identities from a given ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1995-03-14 00:00:00