Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium.

abstract：:The Lyz endolysin of bacteriophage P1 was found to cause lysis of the host without a holin. Induction of a plasmid-cloned lyz resulted in lysis, and the lytic event could be triggered prematurely by treatments that dissipate the proton-motive force. Instead of requiring a holin, export was mediated by an N-terminal tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Struck DK,Deaton J,Wang IN,Young R

更新日期：2004-04-27 00:00:00

abstract：:Decision-making in a natural environment depends on a hierarchy of interacting decision processes. A high-level strategy guides ongoing choices, and the outcomes of those choices determine whether or not the strategy should change. When the right decision strategy is uncertain, as in most natural settings, feedback be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell BA,Kiani R

更新日期：2016-08-02 00:00:00

abstract：:The ability to integrate visual information over space is a fundamental component of human pattern vision. Regardless of whether it is for detecting luminance contrast or for recognizing objects in a cluttered scene, the position of the target in the visual field governs the size of a window within which visual inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon M,Liu R

更新日期：2019-02-26 00:00:00

abstract：:The mucopolysaccharidoses are a group of genetic diseases characterized by storage of incompletely degraded glycosaminoglycans. Such storage causes marked distortion of many tissues with consequent severe somatic changes and mental retardation. Storage of glycosaminoglycans results from markedly diminished activity of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorfman A,Matalon R

更新日期：1976-02-01 00:00:00

abstract：:The redox potentials of electron transfer proteins vary over a wide range, even when the type of redox center is the same. Rees [Proc. Natl. Acad. Sci. USA (1985) 82, 3082-3085] proposed that this variation of redox potential partly reflects the different net charges of the proteins, and he presented a linear correlat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore GR,Pettigrew GW,Rogers NK

更新日期：1986-07-01 00:00:00

abstract：:The polycystic kidney diseases (PKDs) are a group of disorders characterized by the growth of epithelial cysts from the nephrons and collecting ducts of kidney tubules. The diseases can be inherited or can be provoked by environmental factors. To investigate the molecular basis of the abnormal cell growth associated w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowley BD Jr,Smardo FL Jr,Grantham JJ,Calvet JP

更新日期：1987-12-01 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:We measured quantitatively the binding affinities of purified Cro repressor to the chemically synthesized wild-type and mutant OR1 operators, consisting of all three possible base-pair substitutions and of thymine to uracil substitutions at each base-pair position of the 17-base-pair operator sequence. The sequence-sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda Y,Sarai A,Rivera VM

更新日期：1989-01-01 00:00:00

abstract：:Bitemporal injections of puromycin that primarily affect the hippocampal-entorhinal area induce amnesia of aversive maze-learning in mice for 3 days after training but are ineffective 6 or more days after training. At these later times, additional puromycin sites covering widespread forebrain areas are necessary to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flexner JB,Flexner LB,Church AC,Rainbow TC,Brunswick DJ

更新日期：1985-11-01 00:00:00

abstract：:Hybrid dysgenesis in Drosophila is a syndrome of gonadal atrophy, sterility, and male recombination, and it occurs in the progeny of crosses between males that harbor certain transposable elements (TEs) and females that lack them. Known examples of hybrid dysgenesis in Drosophila melanogaster result from mobilization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenstiel JP,Hartl DL

更新日期：2005-11-01 00:00:00

abstract：:If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

更新日期：1992-06-15 00:00:00

abstract：:As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin EJ,Cao Y,Enkavi G,Quick M,Pan Y,Tajkhorshid E,Zhou M

更新日期：2012-07-10 00:00:00

abstract：:The versatility of CRISPR-Cas endonucleases as a tool for biomedical research has led to diverse applications in gene editing, programmable transcriptional control, and nucleic acid detection. Most CRISPR-Cas systems, however, suffer from off-target effects and unpredictable nonspecific binding that negatively impact ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Specht DA,Xu Y,Lambert G

更新日期：2020-05-26 00:00:00

abstract：:This distance between a base next to the anticodon of tRNA and the 3' CpCpA terminus of the molecule has been estimated by singlet-singlet energy transfer experiments. The energy donor was the Y base of unknown structure found in yeast tRNA(phe). Three different energy acceptors were used: acriflavine, proflavinyl ace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beardsley K,Cantor CR

更新日期：1970-01-01 00:00:00

abstract：:Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1974-05-01 00:00:00

abstract：:Glands of the uterus are essential for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands of the uterus and a critical regulator of glandular epithelium (GE) differentiation, development, and function. Mice with a conditional deletion of FOXA2 in the adult uterus, created using th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhakal P,Kelleher AM,Behura SK,Spencer TE

更新日期：2020-09-22 00:00:00

abstract：:The mitochondrial enzyme glutaminase C (GAC) catalyzes the hydrolysis of glutamine to glutamate plus ammonia, a key step in the metabolism of glutamine by cancer cells. Recently, we discovered a class of allosteric inhibitors of GAC that inhibit cancer cell growth without affecting their normal cellular counterparts, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stalnecker CA,Ulrich SM,Li Y,Ramachandran S,McBrayer MK,DeBerardinis RJ,Cerione RA,Erickson JW

更新日期：2015-01-13 00:00:00

abstract：:Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell TR

更新日期：1979-09-01 00:00:00

abstract：:In an earlier paper, the author jointly with S. Suryawanshi proposed statistical analysis of shape through triangulation of landmarks on objects. It was observed that the angles of the triangles are invariant to scaling, location, and rotation of objects. No distinction was made between an object and its reflection. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao CR

更新日期：2000-03-28 00:00:00

abstract：:Transgenic mice harboring the int-2/Fgf-3 protooncogene under transcriptional control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit a dramatic, benign hyperplasia of the mammary gland. In one int-2 transgenic line (TG.NX), this growth disturbance is evoked by pregnancy and regresses after parturiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee FS,Lane TF,Kuo A,Shackleford GM,Leder P

更新日期：1995-03-14 00:00:00

abstract：:Neuropathogenicity of poliovirus can be attenuated by mutations in the internal ribosomal entry site (IRES) within the 5' nontranslated region of its genome. The Sabin vaccine strains used in prevention of poliomyelitis carry such mutations in their IRES elements. In addition, mutations within the structural and nonst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gromeier M,Alexander L,Wimmer E

更新日期：1996-03-19 00:00:00

abstract：:Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to characterize proteins associated with the F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kunova Bosakova M,Nita A,Gregor T,Varecha M,Gudernova I,Fafilek B,Barta T,Basheer N,Abraham SP,Balek L,Tomanova M,Fialova Kucerova J,Bosak J,Potesil D,Zieba J,Song J,Konik P,Park S,Duran I,Zdrahal Z,Smajs D,Jans

更新日期：2019-03-05 00:00:00

abstract：:cDNA clones encoding a glucose transporter-like protein have been isolated from adult human liver and kidney cDNA libraries by cross-hybridization with the human HepG2/erythrocyte glucose transporter cDNA. Analysis of the sequence of this 524-amino acid glucose transporter-like protein indicates that it has 55.5% iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukumoto H,Seino S,Imura H,Seino Y,Eddy RL,Fukushima Y,Byers MG,Shows TB,Bell GI

更新日期：1988-08-01 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:Neutrinos represent a new "window" to the Universe, spanning a large range of energy. We discuss the science of neutrino astrophysics and focus on two energy regimes. At "lower" energies ( approximately 1 MeV), studies of neutrinos born inside the sun, or produced in interactions of cosmic rays with the atmosphere, ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Besson D,Cowen D,Selen M,Wiebusch C

更新日期：1999-12-07 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at HS loci. Here we have employed in situ Hi-C to determine how heat stress affects long-range chromatin conformation in human and Drosophila cells. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray J,Munn PR,Vihervaara A,Lewis JJ,Ozer A,Danko CG,Lis JT

更新日期：2019-09-24 00:00:00

abstract：:Disulfide bonds have only rarely been found in intracellular proteins. That pattern is consistent with the chemically reducing environment inside the cells of well-studied organisms. However, recent experiments and new calculations based on genomic data of archaea provide striking contradictions to this pattern. Our r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallick P,Boutz DR,Eisenberg D,Yeates TO

更新日期：2002-07-23 00:00:00

abstract：:The proliferating cell nuclear antigen (PCNA) acts as a processivity factor for replicative DNA polymerases and is essential for DNA replication. In vitro studies have suggested a role for PCNA-in the repair synthesis step of nucleotide excision repair, and PCNA interacts with the cyclin-dependent kinase inhibitor p21...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres-Ramos CA,Yoder BL,Burgers PM,Prakash S,Prakash L

更新日期：1996-09-03 00:00:00