Blockade of beta 1- but not of beta 2-adrenergic receptors replicates propranolol's suppression of the cerebral spread of an engram in mice.

abstract：:The accuracy of computer predictions of RNA secondary structure from sequence data and free energy parameters has been increased to roughly 70%. Performance is judged by comparison with structures known from phylogenetic analysis. The algorithm also generates suboptimal structures. On average, the best structure withi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaeger JA,Turner DH,Zuker M

更新日期：1989-10-01 00:00:00

abstract：:Short oxygen-halogen interactions have been known in organic chemistry since the 1950s and recently have been exploited in the design of supramolecular assemblies. The present survey of protein and nucleic acid structures reveals similar halogen bonds as potentially stabilizing inter- and intramolecular interactions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Auffinger P,Hays FA,Westhof E,Ho PS

更新日期：2004-11-30 00:00:00

abstract：:An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of this information has centered around the agonist-dependent activation of the mitogen-activated protein (MAP) kinases. Although this intracellular signal transduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blenis J

更新日期：1993-07-01 00:00:00

abstract：:A biological membrane is conceptualized as a system in which membrane proteins are naturally matched to the equilibrium thickness of the lipid bilayer. Cholesterol, in addition to lipid composition, has been suggested to be a major regulator of bilayer thickness in vivo because measurements in vitro have shown that ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra K,Ubarretxena-Belandia I,Taguchi T,Warren G,Engelman DM

更新日期：2004-03-23 00:00:00

abstract：:HIV type 1 (HIV-1) specifically uses host cell tRNALys-3 as a primer for reverse transcription. The 3' 18 nucleotides of this tRNA are complementary to a region on the HIV RNA genome known as the primer binding site (PBS). HIV-1 has a strong preference for maintaining a lysine-specific PBS in vivo, and viral genomes w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan B,Musier-Forsyth K

更新日期：1997-12-09 00:00:00

abstract：:The precise determination of de novo genetic variants has enormous implications across different fields of biology and medicine, particularly personalized medicine. Currently, de novo variations are identified by mapping sample reads from a parent-offspring trio to a reference genome, allowing for a certain degree of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gómez-Romero L,Palacios-Flores K,Reyes J,García D,Boege M,Dávila G,Flores M,Schatz MC,Palacios R

更新日期：2018-05-22 00:00:00

abstract：:What are the neural bases of semantic memory? Traditional beliefs that the temporal lobes subserve the retrieval of semantic knowledge, arising from lesion studies, have been recently called into question by functional neuroimaging studies finding correlations between semantic retrieval and activity in left prefrontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson-Schill SL,Swick D,Farah MJ,D'Esposito M,Kan IP,Knight RT

更新日期：1998-12-22 00:00:00

abstract：:Glutaredoxins (Grxs) have been identified across taxa as important mediators in various physiological functions. A chloroplastic monothiol glutaredoxin, AtGRXS16 from Arabidopsis thaliana, comprises two distinct functional domains, an N-terminal domain (NTD) with GlyIleTyr-TyrIleGly (GIY-YIG) endonuclease motif and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Liu S,Feng Y,Liu JZ,Chen Y,Pham K,Deng H,Hirschi KD,Wang X,Cheng N

更新日期：2013-06-04 00:00:00

abstract：:The patterns of variations in fisheries time series are known to result from a complex combination of species and fisheries dynamics all coupled with environmental forcing (including climate, trophic interactions, etc.). Disentangling the relative effects of these factors has been a major goal of fisheries science for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouyer T,Fromentin JM,Ménard F,Cazelles B,Briand K,Pianet R,Planque B,Stenseth NC

更新日期：2008-04-08 00:00:00

abstract：:The alternative splicing of mRNA is a critical process in higher eukaryotes that generates substantial proteomic diversity. Many of the proteins that are essential to this process contain arginine/serine-rich (RS) domains. ZRANB2 is a widely-expressed and highly-conserved RS-domain protein that can regulate alternativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loughlin FE,Mansfield RE,Vaz PM,McGrath AP,Setiyaputra S,Gamsjaeger R,Chen ES,Morris BJ,Guss JM,Mackay JP

更新日期：2009-04-07 00:00:00

abstract：:Duplication of genomic segments provides a primary resource for the origin of evolutionary novelties. However, most previous studies have focused on duplications of complete protein-coding genes, whereas little is known about the significance of duplication segments that are entirely internal to genes. Our examination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Lynch M

更新日期：2009-12-08 00:00:00

abstract：:A Mr 70,000 protein was isolated from cytotoxic human large granular lymphocytes and shown to have cytotoxic activity. The protein was demonstrated to be immunochemically related to the ninth component (C9) of complement and was therefore designated C9-related protein (C9RP). This finding suggests that C9RP and C9 sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Brothers MA,Chiu FJ,Müller-Eberhard HJ

更新日期：1986-07-01 00:00:00

abstract：:The unique ability of bovine papillomavirus (BPV-1) DNA to replicate as a stable, multicopy plasmid in transformed mouse cells has led to its utilization as a eukaryotic cloning vector. One limitation of the system has been the marked reduction in transformation efficiency when BPV-1 DNA or the subgenomic transforming...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarver N,Byrne JC,Howley PM

更新日期：1982-12-01 00:00:00

abstract：:Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs during an infection, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aresta-Branco F,Sanches-Vaz M,Bento F,Rodrigues JA,Figueiredo LM

更新日期：2019-10-08 00:00:00

abstract：:Sequencing of a 360-nucleotide segment of the mitochondrial control region for 63 individuals from an Amerindian tribe, the Nuu-Chah-Nulth of the Pacific Northwest, revealed the existence of 28 lineages defined by 26 variable positions. This represents a substantial level of mitochondrial diversity for a small local p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward RH,Frazier BL,Dew-Jager K,Pääbo S

更新日期：1991-10-01 00:00:00

abstract：:R. A. Fisher's 1930 "reproductive value" is defined as the contribution made by a population's initial age elements to its asymptotically dominating exponential growth mode. For the Leslie discrete-time model, it is the characteristic row vector of the Leslie matrix, and for the integral-equation model of Lotka the si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelson PA

更新日期：1977-11-01 00:00:00

abstract：:We report here on the isolation and characterization of a serotonin (5HT) transporter from Drosophila melanogaster. A 3.1-kb complementary DNA clone (dSERT) was found to encode a protein of 622 amino acid residues with a predicted molecular mass of approximately 69 kDa and a putative transmembrane topology characteris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demchyshyn LL,Pristupa ZB,Sugamori KS,Barker EL,Blakely RD,Wolfgang WJ,Forte MA,Niznik HB

更新日期：1994-05-24 00:00:00

abstract：:The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires clear understanding of the model, has increased the interest in interpretable machine learning. The widely used Classification and Regression Trees (CART) have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luna JM,Gennatas ED,Ungar LH,Eaton E,Diffenderfer ES,Jensen ST,Simone CB 2nd,Friedman JH,Solberg TD,Valdes G

更新日期：2019-10-01 00:00:00

abstract：:Hybrid wheat plants are superior in yield and growth characteristics compared with their homozygous parents. The commercial production of wheat hybrids is difficult because of the inbreeding nature of wheat and the lack of a practical fertility control that enforces outcrossing. We describe a hybrid wheat system that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempe K,Rubtsova M,Gils M

更新日期：2014-06-24 00:00:00

abstract：:Female Utetheisa ornatrix exercise postcopulatory mate selection, favoring sperm of larger males. Larger males also produce larger spermatophores, raising the question whether males are selected on the basis of body size or the size of their spermatophore. We here present evidence, based on matings in which males were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaMunyon CW,Eisner T

更新日期：1994-07-19 00:00:00

abstract：:The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," which is necessary for binding to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakakura C,Yamaguchi-Iwai Y,Satake M,Bae SC,Takahashi A,Ogawa E,Hagiwara A,Takahashi T,Murakami A,Makino K

更新日期：1994-11-22 00:00:00

abstract：:Cubic cage compounds composed of Co-CN-Ru linkages have been prepared which illustrate the following features: (i) new motifs for alkali metal ion complexation (i.e., cationic receptors for cations), (ii) a new family of triaza-metalloligands, and (iii) a double box-like cage. The cages are synthesized by the condensa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contakes SM,Kuhlman ML,Ramesh M,Wilson SR,Rauchfuss TB

更新日期：2002-04-16 00:00:00

abstract：:Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrelli A,Circosta P,Granziero L,Mazzone M,Pisacane A,Fenoglio S,Comoglio PM,Giordano S

更新日期：2006-03-28 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:We exploit the unusual genome organization of the ciliate cell to analyze the control of specific gene amplification during a nuclear differentiation process. Ciliates contain two types of nuclei within one cell, the macronucleus and the micronucleus; and after sexual reproduction a new macronucleus is formed from a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heyse G,Jönsson F,Chang WJ,Lipps HJ

更新日期：2010-12-21 00:00:00

abstract：:The relationship between performance and ability is a central concern in the social sciences: Are the most successful much more able than others, and are failures unskilled? Prior research has shown that noise and self-reinforcing dynamics make performance unpredictable and lead to a weak association between ability a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denrell J,Liu C

更新日期：2012-06-12 00:00:00

abstract：:Spiperone, a dopamine antagonist widely used as a specific ligand for dopamine and serotonin receptors, is actively accumulated into the F4C1 strain of rat pituitary tumor cells. The accumulation of 10 nM [3H]spiperone was linear for 3 min and reached a steady state after 10 min. Spiperone accumulation was reduced 50%...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dannies PS,Rudnick MS,Fishkes H,Rudnick G

更新日期：1984-03-01 00:00:00

abstract：:We examine a nonreciprocally coupled dynamical model of a mixture of two diffusing species. We demonstrate that nonreciprocity, which is encoded in the model via antagonistic cross-diffusivities, provides a generic mechanism for the emergence of traveling patterns in purely diffusive systems with conservative dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You Z,Baskaran A,Marchetti MC

更新日期：2020-08-18 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is synthesized in the brain, and a single type of cloned receptor for the N-terminal portion of PTHrP and PTH is present in the central nervous system. Nothing is known about the physiological actions or signaling pathways used by PTHrP in the brain. Using cultured rat hippo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukayama S,Tashjian AH Jr,Davis JN,Chisholm JC

更新日期：1995-10-24 00:00:00

abstract：:The gene encoding the rice transcription factor, REB (rice endosperm bZIP) was cloned from a bacterial artificial chromosome library of rice. The cloned 6,227-bp-long Reb gene is composed of six exons and five introns and is flanked by a 1.2-kb 5' promoter and a 1.2-kb 3' terminator region. The function of the Reb gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang D,Wu L,Hwang YS,Chen L,Huang N

更新日期：2001-09-25 00:00:00