The mucopolysaccharidoses (a review).

abstract：:The recognition of carrier proteins by multiple catalytic partners occurs in every cycle of chain elongation in the biosynthesis of fatty acids and of the pharmacologically important polyketide and nonribosomal peptide natural products. To dissect the features of carrier proteins that determine specific recognition at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Z,Lai JR,Walsh CT

更新日期：2007-07-10 00:00:00

abstract：:We have utilized a recombinant vector system designed to study gene control elements by fusing them to the Escherichia coli galactokinase gene (galK) to examine the effects of gene expression that result from introducing changes into the 5' noncoding leader region of the galK transcription unit. We varied the length o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansen H,Schümperli D,Rosenberg M

更新日期：1984-12-01 00:00:00

abstract：:Pure cultures of human breast epithelial cells and of fibroblastic cells in early passage provided the opportunity to ask whether either cell type had the capability for metabolizing chemical carcinogens and, if so, was the fate of the metabolic products compatible with chemical carcinogens being a factor in the initi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stampfer MR,Bartholomew JC,Smith HS,Bartley JC

更新日期：1981-10-01 00:00:00

abstract：:Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debenham PG,Pongs O,Travers AA

更新日期：1980-02-01 00:00:00

abstract：:We have cloned and partially characterized 24 loci from the human genome which are complementary to U1, U2, or U3, the three major species of small nuclear RNA (snRNA) in HeLa cells. When compared to the known U1 (human) and U2 (rat) snRNA sequences, the DNA sequences we report here for the complementary regions from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denison RA,Van Arsdell SW,Bernstein LB,Weiner AM

更新日期：1981-02-01 00:00:00

abstract：:The accuracy of the 3'-end processing by cleavage and polyadenylation is essential for mRNA biogenesis and transcription termination. In yeast, two poorly conserved neighboring elements upstream of cleavage sites are important for accuracy and efficiency of this process. These two RNA sequences are recognized by the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnwal RP,Lee SD,Moore C,Varani G

更新日期：2012-12-26 00:00:00

abstract：:Quinate:NAD(+) 3-oxidoreductase (EC 1.1.1.24) from carrot cell suspension cultures has previously been shown to be activated by phosphorylation and inactivated by dephosphorylation. Here it is shown that the reactivation of the inactivated quinate:NAD(+) oxidoreductase is an enzyme-mediated process that requires ATP a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranjeva R,Refeno G,Boudet AM,Marmé D

更新日期：1983-09-01 00:00:00

abstract：:We have studied the in vivo signaling mechanisms involved in nociceptin/orphanin FQ (Noci)-induced pain responses by using a flexor-reflex paradigm. Noci was 10,000 times more potent than substance P (SP) in eliciting flexor responses after intraplantar injection into the hind limb of mice, but the action of Noci seem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue M,Kobayashi M,Kozaki S,Zimmer A,Ueda H

更新日期：1998-09-01 00:00:00

abstract：:Adolescent trauma (AT) is a common risk factor for adult-onset posttraumatic stress disorder (PTSD). However, the vulnerability to AT among different individuals varies dramatically, indicating that other cofactors are important. Despite extensive studies, the identification of those cofactors has had little success. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph A,Tang M,Mamiya T,Chen Q,Yang LL,Jiao J,Yu N,Tang YP

更新日期：2013-04-16 00:00:00

abstract：:The histidine periplasmic permease of Salmonella typhimurium has been partially purified and reconstituted into proteoliposomes. In this in vitro preparation, transport activity is completely dependent on the presence of all four permease proteins (HisJ, HisQ, HisM, and HisP) and on internal ATP. The reconstituted sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishop L,Agbayani R Jr,Ambudkar SV,Maloney PC,Ames GF

更新日期：1989-09-01 00:00:00

abstract：:Male oriental fruit flies (Dacus dorsalis) from colonies in Taiwan and Hawaii were evaluated for limit of response to various analogues of methyl eugenol. The results are interpreted in terms of the geometry and allosteric requirements of the antennal receptor that triggers the characteristic methyl eugenol reflex. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf RL,Metcalf ER,Mitchell WC,Lee LW

更新日期：1979-04-01 00:00:00

abstract：:Smooth muscle cells use fibronectin to bind to type I and type III collagens but bind to type V collagen by a trypsin-resistant intrinsic glycoconjugate. The binding site on type V collagen is located in the alpha A chain. By using collagen-coated filters in a modified Boyden chamber assay for chemotaxis, it was obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grotendorst GR,Seppä HE,Kleinman HK,Martin GR

更新日期：1981-06-01 00:00:00

abstract：:Mahler proved the following quantitative result supplementing the Lindemann-Weierstrass theorem: Sigma(i=0) (n)C(i)e(ri) > H(-n-epsilon) for any distinct rational numbers r(0),r(1),..., r(n) and rational integers C(0),C(1),...,C(n) with H = max(0

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky GV

更新日期：1983-05-01 00:00:00

abstract：:The receptor 2B4 belongs to the Ig superfamily and is found on the surface of all murine natural killer (NK) cells as well as T cells displaying non-MHC-restricted cytotoxicity. Previous studies have suggested that 2B4 is an activating molecule because cross-linking of this receptor results in increased cytotoxicity a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schatzle JD,Sheu S,Stepp SE,Mathew PA,Bennett M,Kumar V

更新日期：1999-03-30 00:00:00

abstract：:Natal dispersal, the process through which immature individuals permanently depart their natal area in search of new sites, is integral to the ecology and evolution of animals. Insights about the underlying causes of natal dispersal arise mainly from research on species whose short dispersal distances or restricted di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studds CE,Kyser TK,Marra PP

更新日期：2008-02-26 00:00:00

abstract：:The core enzyme of Escherichia coli RNA polymerase acquires essential promoter recognition and transcription initiation activities by binding one of several sigma subunits. To characterize the proximity between sigma70, the major sigma for transcription of the growth-related genes, and the core enzyme subunits (alpha2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owens JT,Miyake R,Murakami K,Chmura AJ,Fujita N,Ishihama A,Meares CF

更新日期：1998-05-26 00:00:00

abstract：:The nonlinear nature of integration among cortical brain areas renders the effective connectivity between them inherently dynamic and context-sensitive. One emerging architectural principle of functional brain organization, which rests explicitly on these nonlinear interactions, is that neuronal responses expressed at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friston KJ,Büchel C

更新日期：2000-06-20 00:00:00

abstract：:Low-barrier hydrogen bonds (LBHBs) have been proposed to play roles in protein functions, including enzymatic catalysis and proton transfer. Transient formation of LBHBs is expected to stabilize specific reaction intermediates. However, based on experimental results and theoretical considerations, arguments against th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi S,Kamikubo H,Kurihara K,Kuroki R,Niimura N,Shimizu N,Yamazaki Y,Kataoka M

更新日期：2009-01-13 00:00:00

abstract：:An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete amino acid sequence of the variable region of the light chain (VL) protein established it as a kappa I, which when compared with other kappa I amyloid associated proteins had unique residues, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schormann N,Murrell JR,Liepnieks JJ,Benson MD

更新日期：1995-10-10 00:00:00

abstract：:The posterodorsal part of the medial nucleus of the amygdala (MeAp) receives its major sensory input from the accessory olfactory bulb and projects massively to the medial preoptic nucleus and other sexually dimorphic hypothalamic nuclei thought to play key roles in mediating steroid-sensitive reproductive functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simerly RB,Young BJ,Capozza MA,Swanson LW

更新日期：1989-06-01 00:00:00

abstract：:The human foamy virus (HFV) genome possesses three open reading frames (bel 1, 2, and 3) located between env and the 3' long terminal repeat. By analogy to other human retroviruses this region was selected as the most likely candidate to encode the viral transactivator. Results presented here confirmed this and showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rethwilm A,Erlwein O,Baunach G,Maurer B,ter Meulen V

更新日期：1991-02-01 00:00:00

abstract：:The complete amino acid sequence of Xenopus laevis nonmuscle myosin heavy chain B (MHC-B) has been deduced from overlapping cDNA clones isolated from an XTC cell library. RNA blots of various developmental stages, adult tissues, and XTC cells detect a single transcript of 7.5 kb which is expressed at similar levels th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatia-Dey N,Adelstein RS,Dawid IB

更新日期：1993-04-01 00:00:00

abstract：:A previously undescribed toothless flying reptile from northeastern China, Nemicolopterus crypticus gen. et sp. nov., was discovered in the lacustrine sediments of the Early Cretaceous Jiufotang Formation, western Liaoning, China. The specimen consists of an almost complete articulated skeleton (IVPP V14377) and, desp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Kellner AW,Zhou Z,Campos Dde A

更新日期：2008-02-12 00:00:00

abstract：:MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts. It is a member of the large ParA superfamily of ATPases that are characterized by a deviant Walker-type ATP-binding motif. MinD localizes to the cytoplasmic face of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szeto TH,Rowland SL,Rothfield LI,King GF

更新日期：2002-11-26 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that transmit diverse extracellular signals across a membrane. Herpesvirus genomes encode multiple GPCRs implicated in viral pathogenesis. Kaposi sarcoma-associated herpesvirus GPCR (kGPCR) activates proliferative pathways and, when expressed in endo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Lu X,Zhu L,Shen Y,Chengedza S,Feng H,Wang L,Jung JU,Gutkind JS,Feng P

更新日期：2013-07-02 00:00:00

abstract：:Peripheral nerve injury induces a robust proregenerative program that drives axon regeneration. While many regeneration-associated genes are known, the mechanisms by which injury activates them are less well-understood. To identify such mechanisms, we performed a loss-of-function pharmacological screen in cultured adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karney-Grobe S,Russo A,Frey E,Milbrandt J,DiAntonio A

更新日期：2018-10-16 00:00:00

abstract：:The Landau spectrum of bismuth is complex and includes many angle-dependent lines in the extreme quantum limit. The adequacy of single-particle theory to describe this spectrum in detail has been an open issue. Here, we present a study of angle-resolved Nernst effect in bismuth, which maps the angle-resolved Landau sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Z,Fauqué B,Malone L,Antunes AB,Fuseya Y,Behnia K

更新日期：2012-09-11 00:00:00

abstract：:Thymidine dinucleotide (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of UV irradiation and UV-mimetic DNA damage. Here it is shown that, in addition to tanning, pTpT induces a second photoprotective response, enhanced repair of UV-induced DNA damage. This enhanced re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eller MS,Maeda T,Magnoni C,Atwal D,Gilchrest BA

更新日期：1997-11-11 00:00:00

abstract：:Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously expressed E3 ubiquitin ligase that targets viruses inside the cytosol, protects mice against fatal viral infection. Upon inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaysburd M,Watkinson RE,Cooper H,Reed M,O'Connell K,Smith J,Cruickshanks J,James LC

更新日期：2013-07-23 00:00:00

abstract：:We have isolated a protein from Saccharomyces cerevisiae that binds specifically to a nucleotide sequence associated with the autonomously replicating sequence (ARS) ARS120, located in the telomeric region of a yeast chromosome. "Footprinting" analysis revealed that a 26-base-pair DNA sequence, 5'-CAAGTGCCGTGCATAATGAT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenberg S,Civalier C,Tye BK

更新日期：1988-02-01 00:00:00