Natal dispersal driven by environmental conditions interacting across the annual cycle of a migratory songbird.

abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

更新日期：2008-12-02 00:00:00

abstract：:Oxidation of molecular hydrogen catalyzed by [NiFe] hydrogenases is a widespread mechanism of energy generation among prokaryotes. Biosynthesis of the H2-oxidizing enzymes is a complex process subject to positive control by H2 and negative control by organic energy sources. In this report we describe a novel signal tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lenz O,Friedrich B

更新日期：1998-10-13 00:00:00

abstract：:The mucopolysaccharidoses are a group of genetic diseases characterized by storage of incompletely degraded glycosaminoglycans. Such storage causes marked distortion of many tissues with consequent severe somatic changes and mental retardation. Storage of glycosaminoglycans results from markedly diminished activity of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorfman A,Matalon R

更新日期：1976-02-01 00:00:00

abstract：:The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-ring stoichiometry determines the number of ions transferred during enzyme operation and has a direct impact on the ion-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preiss L,Klyszejko AL,Hicks DB,Liu J,Fackelmayer OJ,Yildiz Ö,Krulwich TA,Meier T

更新日期：2013-05-07 00:00:00

abstract：:Changes in levels of the newly discovered cytidine 3':5'-cyclic monophosphate (cyclic CMP) phosphodiesterase in some representative tissues (cerebral cortex, kidney, intestine, liver, heart, and lung) of guinea pigs from various developmental stages (fetus, neonate, pup, and adult) were studied and compared with those...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfman DM,Brackett NL,Kuo JF

更新日期：1978-09-01 00:00:00

abstract：:The remarkable fidelity of most DNA polymerases depends on a series of early steps in the reaction pathway which allow the selection of the correct nucleotide substrate, while excluding all incorrect ones, before the enzyme is committed to the chemical step of nucleotide incorporation. The conformational transitions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santoso Y,Joyce CM,Potapova O,Le Reste L,Hohlbein J,Torella JP,Grindley ND,Kapanidis AN

更新日期：2010-01-12 00:00:00

abstract：:The endometrial epithelium of the uterus regenerates periodically. The cellular source of newly regenerated endometrial epithelia during a mouse estrous cycle or a human menstrual cycle is presently unknown. Here, I have used single-cell lineage tracing in the whole mouse uterus to demonstrate that epithelial stem cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin S

更新日期：2019-04-02 00:00:00

abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh H,Medina KL,Pongubala JM

更新日期：2005-04-05 00:00:00

abstract：:Many experiments have been done to determine how far and how freely holes can move along the stack of base pairs in DNA. The results of these experiments are usually described in terms of a parameter beta under the assumption that it describes an exponential decay with distance. The reported values range from beta < 0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conwell EM,Rakhmanova SV

更新日期：2000-04-25 00:00:00

abstract：:IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by IFN-alpha/beta are the ubiquitin-like ISG15 protein and its E1- (Ube1L) and E2- (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins. It is likely that ISG15 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Denison C,Huibregtse JM,Gygi S,Krug RM

更新日期：2005-07-19 00:00:00

abstract：:We have used in vitro motility assays to investigate the mechanism of kinetochore function in the budding yeast Saccharomyces cerevisiae. Functional centromeric DNA plus a tripartite centromere binding protein complex, CBF3, was found to be necessary but not sufficient for in vitro kinetochore activity. A fourth requi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Middleton K,Carbon J

更新日期：1994-07-19 00:00:00

abstract：:Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial-mesenchymal transition (EMT) has been noted as a critical pheno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakuma K,Aoki M,Kannagi R

更新日期：2012-05-15 00:00:00

abstract：:We discuss the generic time behavior of reaction-diffusion processes capable of modeling various types of biological transport processes, such as ligand migration in proteins and gating fluctuations in ion channel proteins. The main observable in these two cases, the fraction of unbound ligands and the probability of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadler W,Stein DL

更新日期：1991-08-01 00:00:00

abstract：:Screening of a human placenta lambda gt11 library has led to the isolation of the cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frielle T,Collins S,Daniel KW,Caron MG,Lefkowitz RJ,Kobilka BK

更新日期：1987-11-01 00:00:00

abstract：:Primates can store sensory stimulus parameters in working memory for subsequent manipulation, but until now, there has been no demonstration of this capacity in rodents. Here we report tactile working memory in rats. Each stimulus is a vibration, generated as a series of velocity values sampled from a normal distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fassihi A,Akrami A,Esmaeili V,Diamond ME

更新日期：2014-02-11 00:00:00

abstract：:Insects, as a group, have been remarkably successful in adapting to a great range of physical and biological environments, in large part because of their ability to fly. The evolution of flight in small insects was accompanied by striking adaptations of the thoracic musculature that enabled very high wing beat frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swank DM,Vishnudas VK,Maughan DW

更新日期：2006-11-14 00:00:00

abstract：:Mismatch repair contributes to genetic stability, and inactivation of the mammalian pathway leads to tumor development. Mismatch correction occurs by an excision-repair mechanism and has been shown to depend on the 5' to 3' hydrolytic activity exonuclease 1 (Exo1) in eukaryotic cells. However, genetic and biochemical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadyrov FA,Genschel J,Fang Y,Penland E,Edelmann W,Modrich P

更新日期：2009-05-26 00:00:00

abstract：:Very-long-baseline interferometry images of the nuclear region of the radio galaxy Cygnus A reveal a pronounced "core" and a knotty jet and counterjet. The knots are moving away from the core at apparent speeds which are subluminal for h = 1 [h = H0/100 km.s-1.Mpc-1;1 parsec (pc) = 3.09 x 10(16)m] and about c for h = ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartel N,Sorathia B,Bietenholz MF,Carilli CL,Diamond P

更新日期：1995-12-05 00:00:00

abstract：:Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Fine Licht HH,Schiøtt M,Rogowska-Wrzesinska A,Nygaard S,Roepstorff P,Boomsma JJ

更新日期：2013-01-08 00:00:00

abstract：:When the visual (striate) cortex (V1) is damaged in human subjects, cortical blindness results in the contralateral visual half field. Nevertheless, under some experimental conditions, subjects demonstrate a capacity to make visual discriminations in the blind hemifield (blindsight), even though they have no phenomena...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiskrantz L,Barbur JL,Sahraie A

更新日期：1995-06-20 00:00:00

abstract：:When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new eve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawarczyk D,Wahlheim CN,Etzel JA,Snyder AZ,Zacks JM

更新日期：2020-11-24 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disease caused by a glutamine expansion within huntingtin protein. The exact pathological mechanisms determining disease onset and progression remain unclear. However, aggregates of insoluble mutant huntingtin (mhtt), a hallmark of HD, are readily detected w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chopra V,Fox JH,Lieberman G,Dorsey K,Matson W,Waldmeier P,Housman DE,Kazantsev A,Young AB,Hersch S

更新日期：2007-10-16 00:00:00

abstract：:Evidence had been provided that a disulfide-linked [125I]iodotyramine/poly(D-lysine) conjugate was reductively cleaved when bound nonspecifically to the surface of Chinese hamster ovary (CHO) cells and that this cleavage was abolished by membrane-impermeant sulfhydryl blockers. The same blockers were subsequently foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandel R,Ryser HJ,Ghani F,Wu M,Peak D

更新日期：1993-05-01 00:00:00

abstract：:The rotation of Paracoccus denitrificans F1-ATPase (PdF1) was studied using single-molecule microscopy. At all concentrations of adenosine triphosphate (ATP) or a slowly hydrolyzable ATP analog (ATPγS), above or below Km, PdF1 showed three dwells per turn, each separated by 120°. Analysis of dwell time between steps s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zarco-Zavala M,Watanabe R,McMillan DGG,Suzuki T,Ueno H,Mendoza-Hoffmann F,García-Trejo JJ,Noji H

更新日期：2020-11-24 00:00:00

abstract：:The tat protein encoded by the human immunodeficiency virus type 1 is a potent trans-activator of gene expression from the viral long terminal repeat. The domains that are essential for trans-activation, a Pro-Xaa3-Pro triad, a cysteine-rich metal-binding sequence motif, and a cluster of basic residues, are present wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeyapaul J,Reddy MR,Khan SA

更新日期：1990-09-01 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:Gene expression has a stochastic component because of the single-molecule nature of the gene and the small number of copies of individual DNA-binding proteins in the cell. We show how the statistics of such systems can be mapped onto quantum many-body problems. The dynamics of a single gene switch resembles the spin-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasai M,Wolynes PG

更新日期：2003-03-04 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) causes growth arrest in most cell types. TGF-beta induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase of the cell cycle, thereby leading to cell cycle arrest at G1. It is possible, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JM,Hu PP,Shen X,Yu Y,Wang XF

更新日期：1997-05-13 00:00:00

abstract：:Agrobacterium tumefaciens transfers the T-DNA portion of its Ti plasmid to the nuclear genome of plant cells. Upon cocultivation of A. tumefaciens strain A348 with regenerating tobacco leaf protoplasts, restriction endonuclease fragments of the T-DNA were generated that are consistent with double-stranded cleavage of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veluthambi K,Jayaswal RK,Gelvin SB

更新日期：1987-04-01 00:00:00

abstract：:Many groups of insects are specialists in exploiting sensory cues to locate food resources or conspecifics. To achieve orientation, bees and ants analyze the polarization pattern of the sky, male moths orient along the females' odor plume, and cicadas, grasshoppers, and crickets use acoustic signals to locate singing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulet JF,Hedwig B

更新日期：2005-10-25 00:00:00