Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice.

abstract：:We have cloned and identified a DNA sequence complementary to the mRNA of creatine kinase (CK) isozyme M, although the mRNA is a minor species of the total mRNA in developing myoblasts. Poly(A)+RNA from breast and thigh muscle of 5-week-old chicks was enriched for CK mRNA by a novel procedure of sucrose gradient centr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweinfest CW,Kwiatkowski RW,Dottin RP

更新日期：1982-08-01 00:00:00

abstract：:There is a tightly coupled bidirectional interaction between visual cortex and visual thalamus [lateral geniculate nucleus (LGN)]. Using drifting sinusoidal grating stimuli, we compared the response of cells in the LGN with and without feedback from the visual cortex. Raster plots revealed a striking difference in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andolina IM,Jones HE,Wang W,Sillito AM

更新日期：2007-01-30 00:00:00

abstract：:rev-regulated expression of HIV-1 envelope proteins from a simian virus 40 late replacement vector was found to be dependent on the presence of a 5' splice site in the env mRNA in spite of the fact that this mRNA remains unspliced. When the 5' splice site upstream of the env open reading frame was deleted or mutated, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu XB,Heimer J,Rekosh D,Hammarskjöld ML

更新日期：1990-10-01 00:00:00

abstract：:Throughout time, operational laws and concepts from complex systems have been employed to quantitatively model important aspects and interactions in nature and society. Nevertheless, it remains enigmatic and challenging, yet inspiring, to predict the actual interdependencies that comprise the structure of such systems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavroglou SK,Pantelous AA,Stanley HE,Zuev KM

更新日期：2020-04-07 00:00:00

abstract：:The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1 that is homologous to the ras GTPase-activating protein (GAP) encodes a similar GTPase-stimulating activity. We have raised rabbit antisera to a bacterially synthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeClue JE,Cohen BD,Lowy DR

更新日期：1991-11-15 00:00:00

abstract：:Purified human platelet-derived growth factor (PDGF) induces an increase in amino acid uptake via system A in quiescent human diploid fibroblasts. Cells must be exposed to PDGF for 45 min to obtain maximum transport stimulation. Transport stimulation requires protein synthesis. Transient exposure to PDGF, alone, in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AJ 3rd,Geyer RP,Antoniades HN

更新日期：1982-05-01 00:00:00

abstract：:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ,Hartzell HC,Yoshikami D

更新日期：1975-08-01 00:00:00

abstract：:Near-zero-index (NZI) supercoupling, the transmission of electromagnetic waves inside a waveguide irrespective of its shape, is a counterintuitive wave effect that finds applications in optical interconnects and engineering light-matter interactions. However, there is a limited knowledge on the local properties of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liberal I,Lobet M,Li Y,Engheta N

更新日期：2020-09-29 00:00:00

abstract：:Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin, CyaA, that is able to deliver its N-terminal catalytic domain (400-aa residues) into the cytosol of eukaryotic target cells, directly through the cytoplasmic membrane. We have previously shown that CyaA can be used as a vehicle to deliver T ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karimova G,Fayolle C,Gmira S,Ullmann A,Leclerc C,Ladant D

更新日期：1998-10-13 00:00:00

abstract：:The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two electrons to the hemeprotein. In general these electrons are transferred from NADPH to the P450 via an FMN- and FAD-containing flavoprotein (NADPH-P450 reductase)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faulkner KM,Shet MS,Fisher CW,Estabrook RW

更新日期：1995-08-15 00:00:00

abstract：:Habituation is a form of simple memory that suppresses neural activity in response to repeated, neutral stimuli. This process is critical in helping organisms guide attention toward the most salient and novel features in the environment. Here, we follow known circuit mechanisms in the fruit fly olfactory system to der...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen Y,Dasgupta S,Navlakha S

更新日期：2020-06-02 00:00:00

abstract：:Acquired immunity to Streptococcus pneumoniae (pneumococcus) has long been assumed to depend on the presence of anticapsular antibodies. We found, however, that colonization with live pneumococci of serotypes 6B, 7F, or 14 protected mice against recolonization by any of the serotypes and that protection from acquisiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malley R,Trzcinski K,Srivastava A,Thompson CM,Anderson PW,Lipsitch M

更新日期：2005-03-29 00:00:00

abstract：:Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics. MicroRNAs regulate both physiological and pathological angiogenesis through modulating expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CH,Sun Y,Li J,Gong Y,Tian KT,Evans LP,Morss PC,Fredrick TW,Saba NJ,Chen J

更新日期：2015-09-29 00:00:00

abstract：:The X gene product encoded by the hepatitis B virus, termed pX, is a promiscuous transactivator of a variety of viral and cellular genes under the control of diverse cis-acting elements. Although pX does not appear to directly bind DNA, pX-responsive elements include the NF-kappa B, AP-1, and CRE (cAMP response elemen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JS,Andrisani OM

更新日期：1995-04-25 00:00:00

abstract：:Understanding modulation of memory, as well as the mechanisms underlying memory formation, has become a key issue in neuroscience research. Previously, we found that the formation of long-term, but not short-term, memory for a nonassociative form of learning, sensitization, was modulated by the circadian clock in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons LC,Rawashdeh O,Katzoff A,Susswein AJ,Eskin A

更新日期：2005-08-30 00:00:00

abstract：:Devastating floods due to Atlantic hurricanes are relatively rare events. However, the frequency of the most intense storms is likely to increase with rises in sea surface temperatures. Geoengineering by stratospheric sulfate aerosol injection cools the tropics relative to the polar regions, including the hurricane Ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore JC,Grinsted A,Guo X,Yu X,Jevrejeva S,Rinke A,Cui X,Kravitz B,Lenton A,Watanabe S,Ji D

更新日期：2015-11-10 00:00:00

abstract：:On the basis of earlier energy computations, the various single peptide units in proteins were designated as helix-making or helix-breaking.(1) With the use of these designations, empirical rules for distinguishing between alpha-helical and non-alpha-helical regions of proteins have been formulated. These rules includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotelchuck D,Scheraga HA

更新日期：1969-01-01 00:00:00

abstract：:Apicomplexan parasites replicate within a protective organelle, called the parasitophorous vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, which are thought to facilitate trafficking of effectors and nutrients. Despite being critical to parasite virulence, there is scant mechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beraki T,Hu X,Broncel M,Young JC,O'Shaughnessy WJ,Borek D,Treeck M,Reese ML

更新日期：2019-03-26 00:00:00

abstract：:The functional capacities of CD8(+) T cells important for virus clearance are influenced by interactions with antigen presenting cells (APCs) and CD4(+) T cells during initial selection, subsequent expansion, and development of memory. Recently, investigators have shown that polyfunctional T cells correlate best with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ndhlovu ZM,Oelke M,Schneck JP,Griffin DE

更新日期：2010-02-23 00:00:00

abstract：:Hearing loss is the main limitation of radiation therapy for vestibular schwannoma (VS), and identifying treatment options that minimize hearing loss are urgently needed. Treatment with bevacizumab is associated with tumor control and hearing improvement in neurofibromatosis type 2 (NF2) patients; however, its effect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Zhao Y,Stemmer-Rachamimov AO,Liu H,Huang P,Chin S,Selig MK,Plotkin SR,Jain RK,Xu L

更新日期：2015-11-24 00:00:00

abstract：:Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrara F,Sengupta A,Behrendt L,Vardi A,Stocker R

更新日期：2021-02-02 00:00:00

abstract：:Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 (Cdc6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yim H,Erikson RL

更新日期：2010-11-16 00:00:00

abstract：:To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines. Dasatinib, a multikinase inhibitor, was ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scuoppo C,Wang J,Persaud M,Mittan SK,Basso K,Pasqualucci L,Rabadan R,Inghirami G,Grandori C,Bosch F,Dalla-Favera R

更新日期：2019-08-20 00:00:00

abstract：:Saccharomyces cerevisiae is one of the most important model organisms and has been a valuable asset to human civilization. However, despite its extensive use in the last 9,000 y, the existence of a seasonal cycle outside human-made environments has not yet been described. We demonstrate the role of social wasps as vec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanini I,Dapporto L,Legras JL,Calabretta A,Di Paola M,De Filippo C,Viola R,Capretti P,Polsinelli M,Turillazzi S,Cavalieri D

更新日期：2012-08-14 00:00:00

abstract：:Our ability to interpret seismic observations including the seismic discontinuities and the density and velocity profiles in the earth's interior is critically dependent on the accuracy of pressure measurements up to 364 GPa at high temperature. Pressure scales based on the reduced shock-wave equations of state alone ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei Y,Ricolleau A,Frank M,Mibe K,Shen G,Prakapenka V

更新日期：2007-05-29 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) binds to specific receptors on GH4C1 pituitary tumor cells. A fluorescently labeled analog of TRH was synthesized by coupling pGlu-His-ProNH(CH2)6NH2 to fluorescein isothiocyanate. The fluorescein-labeled peptide (FL-TRH) stimulated prolactin synthesis and release by GH4C1 cultures ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern J,Hinkle PM

更新日期：1981-01-01 00:00:00

abstract：:Electron microscopic techniques have been used to reveal two classes of subunits of tubulin in ordered arrays. Presumably the two classes correspond to the alpha and beta polypeptide chains of tubulin that have been distinguished by chemical criteria. The two types of subunits alternate along individual protofilaments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crepeau RH,McEwen B,Edelstein SJ

更新日期：1978-10-01 00:00:00

abstract：:The mutagenic effect of low linear energy transfer ionizing radiation is reduced for a given dose as the dose rate (DR) is reduced to a low level, a phenomenon known as the direct DR effect. Our reanalysis of published data shows that for both somatic and germ-line mutations there is an opposite, inverse DR effect, wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vilenchik MM,Knudson AG Jr

更新日期：2000-05-09 00:00:00

abstract：:Protein-tyrosine kinases (PTKs) are critical enzymes for receptor-mediated signaling in lymphocytes. Because natural killer (NK) cells are large granular lymphocytes with specialized effector function, we set out to identify PTKs preferentially expressed in these cells. One such PTK was identified and molecularly clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawamura M,McVicar DW,Johnston JA,Blake TB,Chen YQ,Lal BK,Lloyd AR,Kelvin DJ,Staples JE,Ortaldo JR

更新日期：1994-07-05 00:00:00

abstract：:We have characterized seven murine retinoic acid receptor gamma cDNA isoforms (mRAR-gamma 1 to -gamma 7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-gamma 1 and -gamma 2) differ in their N-terminal A region, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kastner P,Krust A,Mendelsohn C,Garnier JM,Zelent A,Leroy P,Staub A,Chambon P

更新日期：1990-04-01 00:00:00