Abstract:
:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, like those from all other vertebrates previously tested, are blocked by these alpha-neurotoxins. In contrast, receptors from snakes and advanced lizards are insensitive to one or both of the toxins. It is suggested that toxin-resistant acetylcholine receptors appeared early in the evolution of Squamata and preceded the appearance of alpha-neurotoxins.
journal_name
Proc Natl Acad Sci U S Aauthors
Burden SJ,Hartzell HC,Yoshikami Ddoi
10.1073/pnas.72.8.3245keywords:
subject
Has Abstractpub_date
1975-08-01 00:00:00pages
3245-9issue
8eissn
0027-8424issn
1091-6490journal_volume
72pub_type
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